MENA_MYCLE
ID MENA_MYCLE Reviewed; 294 AA.
AC O07134;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=1,4-dihydroxy-2-naphthoate octaprenyltransferase {ECO:0000255|HAMAP-Rule:MF_01937};
DE Short=DHNA-octaprenyltransferase {ECO:0000255|HAMAP-Rule:MF_01937};
DE EC=2.5.1.74 {ECO:0000255|HAMAP-Rule:MF_01937};
GN Name=menA {ECO:0000255|HAMAP-Rule:MF_01937}; OrderedLocusNames=ML2406;
GN ORFNames=MLB1306.02c;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- FUNCTION: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to
CC demethylmenaquinone (DMK). {ECO:0000255|HAMAP-Rule:MF_01937}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl
CC diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate;
CC Xref=Rhea:RHEA:26478, Rhea:RHEA-COMP:9563, Rhea:RHEA-COMP:9564,
CC ChEBI:CHEBI:11173, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:55437, ChEBI:CHEBI:58914; EC=2.5.1.74;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01937};
CC -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis;
CC menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.
CC {ECO:0000255|HAMAP-Rule:MF_01937}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01937};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01937}.
CC -!- SIMILARITY: Belongs to the MenA family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01937}.
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DR EMBL; Y13803; CAA74132.1; -; Genomic_DNA.
DR EMBL; AL583925; CAC31922.1; -; Genomic_DNA.
DR PIR; B87210; B87210.
DR RefSeq; NP_302556.1; NC_002677.1.
DR RefSeq; WP_010908876.1; NC_002677.1.
DR AlphaFoldDB; O07134; -.
DR SMR; O07134; -.
DR STRING; 272631.ML2406; -.
DR EnsemblBacteria; CAC31922; CAC31922; CAC31922.
DR KEGG; mle:ML2406; -.
DR PATRIC; fig|272631.5.peg.4629; -.
DR Leproma; ML2406; -.
DR eggNOG; COG1575; Bacteria.
DR HOGENOM; CLU_043611_1_0_11; -.
DR OMA; QWIEGAR; -.
DR UniPathway; UPA00079; UER00168.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0046428; F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd13962; PT_UbiA_UBIAD1; 1.
DR HAMAP; MF_01937; MenA_1; 1.
DR InterPro; IPR004657; MenA.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR InterPro; IPR026046; UBIAD1.
DR PANTHER; PTHR13929; PTHR13929; 1.
DR Pfam; PF01040; UbiA; 1.
DR PIRSF; PIRSF005355; UBIAD1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Menaquinone biosynthesis; Reference proteome;
KW Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..294
FT /note="1,4-dihydroxy-2-naphthoate octaprenyltransferase"
FT /id="PRO_0000096417"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01937"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01937"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01937"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01937"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01937"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01937"
SQ SEQUENCE 294 AA; 30671 MW; DAC9F77ABD3157E1 CRC64;
MASFAQWISG ARPRTLPNAV APVVAGTGTA AWLHSAVWWK ALLALVVAVA LVIGVNYAND
YSDGIRGTDD HRAGPMRLVG SRLAFPRSVL TAAVVGLTVS TVAGLALALL SAPWLIMVGA
TCIAGAWLYT GSSKPYGYKG FGEVAVFVFF GLVAVLGTEY TQALRVDWVG LVLAVSTGAL
SSSVLVANNL RDIHTDTQSH KFTLAVRLGD AHTRQLYQAL LVATGVLTVV LMVATSWCAV
GLVATPLALR AMRPVRSGRM GPDLTPVLRD TGLAMVVWAI AVAGALTLAG SVTY
