ARHGH_MOUSE
ID ARHGH_MOUSE Reviewed; 2057 AA.
AC Q80U35; Q8BZY4;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Rho guanine nucleotide exchange factor 17;
GN Name=Arhgef17; Synonyms=Kiaa0337;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1865-2057.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142; SER-152; SER-305;
RP SER-308; SER-324; SER-330; SER-377; SER-381; SER-389; SER-611; SER-689;
RP THR-692; THR-695; SER-728; SER-953; SER-994 AND SER-1324, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RhoA
CC GTPases. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q80U35-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80U35-2; Sequence=VSP_025104, VSP_025105;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC65532.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK122250; BAC65532.1; ALT_INIT; mRNA.
DR EMBL; AC116586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC150744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK033211; BAC28199.2; ALT_SEQ; mRNA.
DR CCDS; CCDS40040.1; -. [Q80U35-1]
DR RefSeq; NP_001074585.1; NM_001081116.1. [Q80U35-1]
DR AlphaFoldDB; Q80U35; -.
DR SMR; Q80U35; -.
DR BioGRID; 228883; 13.
DR IntAct; Q80U35; 2.
DR STRING; 10090.ENSMUSP00000102647; -.
DR iPTMnet; Q80U35; -.
DR PhosphoSitePlus; Q80U35; -.
DR jPOST; Q80U35; -.
DR MaxQB; Q80U35; -.
DR PaxDb; Q80U35; -.
DR PeptideAtlas; Q80U35; -.
DR PRIDE; Q80U35; -.
DR ProteomicsDB; 273933; -. [Q80U35-1]
DR ProteomicsDB; 273934; -. [Q80U35-2]
DR Antibodypedia; 947; 74 antibodies from 27 providers.
DR Ensembl; ENSMUST00000107032; ENSMUSP00000102647; ENSMUSG00000032875. [Q80U35-1]
DR Ensembl; ENSMUST00000209041; ENSMUSP00000146564; ENSMUSG00000032875. [Q80U35-2]
DR GeneID; 207212; -.
DR KEGG; mmu:207212; -.
DR UCSC; uc009inu.1; mouse. [Q80U35-2]
DR UCSC; uc009inv.1; mouse. [Q80U35-1]
DR CTD; 9828; -.
DR MGI; MGI:2673002; Arhgef17.
DR VEuPathDB; HostDB:ENSMUSG00000032875; -.
DR eggNOG; KOG3522; Eukaryota.
DR GeneTree; ENSGT00940000153798; -.
DR HOGENOM; CLU_237760_0_0_1; -.
DR InParanoid; Q80U35; -.
DR OMA; MGQLEPV; -.
DR OrthoDB; 44892at2759; -.
DR PhylomeDB; Q80U35; -.
DR TreeFam; TF324157; -.
DR Reactome; R-MMU-193648; NRAGE signals death through JNK.
DR Reactome; R-MMU-416482; G alpha (12/13) signalling events.
DR Reactome; R-MMU-8980692; RHOA GTPase cycle.
DR Reactome; R-MMU-9013026; RHOB GTPase cycle.
DR Reactome; R-MMU-9013106; RHOC GTPase cycle.
DR BioGRID-ORCS; 207212; 0 hits in 74 CRISPR screens.
DR ChiTaRS; Arhgef17; mouse.
DR PRO; PR:Q80U35; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q80U35; protein.
DR Bgee; ENSMUSG00000032875; Expressed in dentate gyrus of hippocampal formation granule cell and 201 other tissues.
DR ExpressionAtlas; Q80U35; baseline and differential.
DR Genevisible; Q80U35; MM.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISO:MGI.
DR GO; GO:0030036; P:actin cytoskeleton organization; ISO:MGI.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; -; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR039917; ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; PTHR12877; 1.
DR PANTHER; PTHR12877:SF15; PTHR12877:SF15; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; SSF48065; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Guanine-nucleotide releasing factor; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..2057
FT /note="Rho guanine nucleotide exchange factor 17"
FT /id="PRO_0000286590"
FT DOMAIN 1059..1247
FT /note="DH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT REGION 20..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1015..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1555..1713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1983..2050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..176
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..762
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..952
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1030
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1633..1683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1996..2011
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2033..2047
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 142
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 152
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 305
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 308
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 324
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 330
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 377
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 381
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 389
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 404
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96PE2"
FT MOD_RES 414
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96PE2"
FT MOD_RES 456
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96PE2"
FT MOD_RES 538
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96PE2"
FT MOD_RES 611
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 689
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 692
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 695
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 728
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 906
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96PE2"
FT MOD_RES 953
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 994
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1324
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..1009
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12693553"
FT /id="VSP_025104"
FT VAR_SEQ 1010..1057
FT /note="DVPAPGPVDLPCLPPSAPPSTETKPSGAARATPDEPAPASKCCSKPQV ->
FT MLQMVKTLAQFTIALEDMRDLGSAAASGESAGGGDGGSDTAEEPGEAQ (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:12693553"
FT /id="VSP_025105"
FT CONFLICT 1366
FT /note="I -> V (in Ref. 1; BAC65532)"
FT /evidence="ECO:0000305"
FT CONFLICT 1566
FT /note="N -> K (in Ref. 1; BAC65532)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2057 AA; 221671 MW; CCB48100B1ECE03C CRC64;
MADGSPRPPL YRSVSFKLLE RWSGGPGPRE EDADTPGLRR RASCRPAAAV PGQPSRRVSK
LASGPPAAPA QPRPLRSLSP SVRQLSRRFD AAGLDDDSTG TRDGGCSSGT TEEAAEGSER
GAWPSVTEMR KLFGGPSSRR PSMDSEALGS TSPDRVSWEP PTRDPRQPPT PPPRTCFPLA
GLRSARPLSG PGIEGRRRRQ HQQQERAQRP ADGLHSWHSF SQPQAGARAS SSSSIASSYP
VSRSRAASSS EEEEEGPQSQ LGPQSPAYLG GHSSGSDEDP NGEDGRRWRG RGLRPGRSQL
VHGCSQDSDE LNPGGLGSAG GVGSPEPPTS PRTSMDEWGT GTQPCLPGPQ ESLRPMSDTG
GAPFRVAKVS FPAYLASPAG SRGSSRYSST ETLKDDDLWS SRSSVGWGVY RSPSFGTGDG
LLLRPQTRSR SKGPVGTARP LRDGGLDLDK NRQRKSLSNP DIASETLTLL SFLRSDLSEL
RVRKPSGGPG NRPLDGRDSP SAGSPMEQSE STLSQSPTSP TTRPTLKDLT ATLRRAKSFS
CSEKPMARRL LRTSALKPSS SELLLAGSGA EEDPLPLVVQ DQYVQEARQV FEKIQRMGAQ
QDDGNDVCPT SPDWAGDMTQ GHRSQEELSG PESNLTDEGI GADPEPLGAA FCSLDPAGVW
RPLSSTSAQT NHHLGAGTED SLGGRALVSP ETPPTPGALR RRRKVPPSGP NGTELSNGEA
SEAYRSLSDP IPQRHRAATS EEPSGFSVDS NLLGSLNSKT GLPVTPAMDE GLTSGHSDWS
VVSEENKDYQ EVIQSIVQGP GALGRMGEDR IAGKTPKKKS LSDPSRRGEL TGPGFEGPGG
EPIREVEPML PPSSSEPILA EQWTEPEDPA PARGRAQSER SLPAPPASST AHHDFHLDPK
LTSVLSPRLT RRGSKKRPAR SSHQELRREE GNQDQTGSLT QTRSSSKHVR HASVPATFTP
IVVPEPAMSV GPPVAAPEPV GFPVRGHPAL QAPSLEDVTK RYMLTLHSGD VPAPGPVDLP
CLPPSAPPST ETKPSGAARA TPDEPAPASK CCSKPQVDMR KHVTMTLLDT EQSYVESLRT
LMQGYMQPLK QPENSLLCDP SLVDEIFDQI PELLEHHEQF LEQVRHCVQT WHAQQKVGAL
LVQSFSKDVL VNIYSAYIDN FLNAKDAVRV AKEARPAFLK FLEQSMRENK EKQALSDLMI
KPVQRIPRYE LLVKDLLKHT PEDHPDHPLL LDAQRNIKQV AERINKGVRS AEEAERHARV
LQEIEAHIEG MEDLQAPLRR FLRQEMVIEV KAIGGKKDRS LFLFTDLIVC TTLKRKSGSL
RRSSMSLYTA ASVIDTASKY KMLWKLPLED TDIIKGASQA TNRETIQKAI SRLDEDLATL
GQMSKLSESL GFPHQSLDDA LRDLSAAMHR DLSEKQALCC SLAFPPTKLE LCATRPEGTD
SYIFEFPHPD ARLGFEQAFD EAKRKLASSK SCLDPEFLKA IPIMKTRSGM QFSCAAPTFS
SCPEPAPEVW VCNSDGYVGQ VCLLSLRAEP DVEACIAVCS ARILCIGAVP GLQPRCPREQ
PEPLRNPPET TLESTGPELD VEATAEEEAA TTLAEPGPQP CLHISISGSG LEMEPGPAKG
DPQPELVPFD SDSDDESSPS PSGTLQSQAS QSTISSSFGN EETPSSKEAT AETTSSEEEQ
EPGFLSLSGS FGPGGPCGTS PMDGRALRRS SRGSFTRGSL EDLLSVDPEA YQSSVWLGTE
DGCVHVYQSS DSIRDRRNSM KLQHAASVTC ILYLNNKVFV SLANGELVVY QREAGRFWDP
QNFKSMTLGS QGSPITKMVS VGGRLWCGCQ NRVLVLSPDT LQLEHTFYVG QDSSRSVACM
VDSSLGVWVT LKGSAHVCLY HPDTFEQLAE VDVTPPVHRM LAGSDAIIRQ HKAACLRITA
LLVCAELLWV GTSAGVVLTI PTSPSTVSCP RAPLSPAGLC QGHTGHVRFL AAVQLPEGFN
LLCSTPPPPP DTGPEKLPSL DHRDSPRRRG PTSARPKMLV ISGGDGSEDF RLSSGGGGSS
ETVGRDDSTN HLLLWRV
