ID   11K_PAVHV               Reviewed;          94 AA.
AC   P0DJZ0;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   12-AUG-2020, entry version 16.
DE   RecName: Full=Host-modulation protein 11K;
DE   AltName: Full=Host-modulation protein of 11 kDa;
GN   Name=11K;
OS   Human parvovirus B19 (strain HV) (HPV B19).
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Quintoviricetes;
OC   Piccovirales; Parvoviridae; Parvovirinae; Erythroparvovirus.
OX   NCBI_TaxID=648237;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Gallinella G., Venturoli S.;
RT   "B19 genome sequence and structure analysis.";
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   INTERACTION WITH HOST GRB2.
RX   PubMed=11878897; DOI=10.1006/viro.2001.1217;
RA   Fan M.M., Tamburic L., Shippam-Brett C., Zagrodney D.B., Astell C.R.;
RT   "The small 11-kDa protein from B19 parvovirus binds growth factor receptor-
RT   binding protein 2 in vitro in a Src homology 3 domain/ligand-dependent
RT   manner.";
RL   Virology 291:285-291(2001).
RN   [3]
RP   FUNCTION.
RX   PubMed=16731932; DOI=10.1128/jvi.02430-05;
RA   Zhi N., Mills I.P., Lu J., Wong S., Filippone C., Brown K.E.;
RT   "Molecular and functional analyses of a human parvovirus B19 infectious
RT   clone demonstrates essential roles for NS1, VP1, and the 11-kilodalton
RT   protein in virus replication and infectivity.";
RL   J. Virol. 80:5941-5950(2006).
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=19861680; DOI=10.1182/blood-2009-04-215756;
RA   Chen A.Y., Zhang E.Y., Guan W., Cheng F., Kleiboeker S., Yankee T.M.,
RA   Qiu J.;
RT   "The small 11 kDa nonstructural protein of human parvovirus B19 plays a key
RT   role in inducing apoptosis during B19 virus infection of primary erythroid
RT   progenitor cells.";
RL   Blood 115:1070-1080(2010).
RN   [5]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=29437973; DOI=10.1128/jvi.02050-17;
RA   Ganaie S.S., Chen A.Y., Huang C., Xu P., Kleiboeker S., Du A., Qiu J.;
RT   "RNA binding protein RBM38 regulates expression of the 11-Kilodalton
RT   protein of Parvovirus B19, which facilitates viral DNA replication.";
RL   J. Virol. 92:0-0(2018).
CC   -!- FUNCTION: Enhances viral DNA replication and virion release
CC       (PubMed:29437973). Plays a role in viral infectivity (PubMed:16731932).
CC       Induces apoptosis of primary erythroid progenitor cells
CC       (PubMed:19861680). {ECO:0000269|PubMed:16731932,
CC       ECO:0000269|PubMed:19861680, ECO:0000269|PubMed:29437973}.
CC   -!- SUBUNIT: Interacts with host GRB2; this interaction alters host cell
CC       environment by modulating host signaling pathways.
CC       {ECO:0000269|PubMed:11878897}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:19861680}.
CC   -!- INDUCTION: Its expression is regulated by host RBM38, probably via
CC       RBM38-dependent splicing of the viral pre-mRNA.
CC       {ECO:0000269|PubMed:29437973}.
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DR   EMBL; AF162273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000006624; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IDA:UniProtKB.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host-virus interaction;
KW   Modulation of host cell apoptosis by virus; Reference proteome.
FT   CHAIN           1..94
FT                   /note="Host-modulation protein 11K"
FT                   /id="PRO_0000428717"
SQ   SEQUENCE   94 AA;  10846 MW;  6760386A554C00AC CRC64;
     MQNNTTGMDT KSLKNCGQPK AVCTHCKHSP PCPQPGCVTK RPPVPPRLYL PPPVPIRQPN
     TKDIDNVEFK YLTRYEQHVI RMLRLCNMYQ NLEK