ID   ARHL1_DANRE             Reviewed;         350 AA.
AC   Q5XJB9;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Inactive ADP-ribosyltransferase arh2 {ECO:0000305};
DE   AltName: Full=ADP-ribosylhydrolase-like protein 1 {ECO:0000305};
DE   AltName: Full=[Protein ADP-ribosylarginine] hydrolase-like protein 1;
GN   Name=adprhl1; Synonyms=arh2; ORFNames=zgc:103446;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for myofibril assembly and outgrowth of the cardiac
CC       chambers in the developing heart (By similarity). Appears to be
CC       catalytically inactive, showing no activity against O-acetyl-ADP-ribose
CC       (By similarity). {ECO:0000250|UniProtKB:Q6AZR2,
CC       ECO:0000250|UniProtKB:Q8BGK2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC       {ECO:0000250|UniProtKB:Q6AZR2}.
CC   -!- SIMILARITY: Belongs to the ADP-ribosylglycohydrolase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Although it belongs to the ADP-ribosylglycohydrolase family,
CC       lacks the metal-binding and substrate-binding residues, suggesting that
CC       it has no hydrolase activity. {ECO:0000250|UniProtKB:Q6AZR2}.
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DR   EMBL; BC083385; AAH83385.1; -; mRNA.
DR   RefSeq; NP_001006033.1; NM_001006033.1.
DR   AlphaFoldDB; Q5XJB9; -.
DR   SMR; Q5XJB9; -.
DR   STRING; 7955.ENSDARP00000060967; -.
DR   PaxDb; Q5XJB9; -.
DR   Ensembl; ENSDART00000060968; ENSDARP00000060967; ENSDARG00000041589.
DR   GeneID; 450012; -.
DR   KEGG; dre:450012; -.
DR   CTD; 113622; -.
DR   ZFIN; ZDB-GENE-041010-126; adprhl1.
DR   eggNOG; ENOG502QPMI; Eukaryota.
DR   GeneTree; ENSGT00530000063627; -.
DR   InParanoid; Q5XJB9; -.
DR   OMA; DATLMHM; -.
DR   OrthoDB; 1112828at2759; -.
DR   PhylomeDB; Q5XJB9; -.
DR   TreeFam; TF329417; -.
DR   PRO; PR:Q5XJB9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 1.
DR   Bgee; ENSDARG00000041589; Expressed in heart and 9 other tissues.
DR   GO; GO:0030017; C:sarcomere; ISS:UniProtKB.
DR   GO; GO:0003875; F:ADP-ribosylarginine hydrolase activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0003242; P:cardiac chamber ballooning; ISS:UniProtKB.
DR   GO; GO:0055003; P:cardiac myofibril assembly; ISS:UniProtKB.
DR   GO; GO:0051725; P:protein de-ADP-ribosylation; IEA:InterPro.
DR   Gene3D; 1.10.4080.10; -; 1.
DR   InterPro; IPR012108; ADP-ribosylarg_hydro.
DR   InterPro; IPR005502; Ribosyl_crysJ1.
DR   InterPro; IPR036705; Ribosyl_crysJ1_sf.
DR   Pfam; PF03747; ADP_ribosyl_GH; 1.
DR   PIRSF; PIRSF016939; ADP_ribslarg_hdr; 1.
DR   SUPFAM; SSF101478; SSF101478; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..350
FT                   /note="Inactive ADP-ribosyltransferase arh2"
FT                   /id="PRO_0000277610"
SQ   SEQUENCE   350 AA;  39201 MW;  93A76C4F9A975D0D CRC64;
     MEKFQAAMVL GAVGDALGSR WQTCSSGSQI QQELRALGGL AALKLDAEHW PLSDGALMHM
     TTAEALITDY WCLEDLYREL VRLYVEAMVS LQGRVPEPST VEGCANLKPH NFLLAWHTPF
     NEKGSGHGAA TKAMCIGMRY WQPERLHTLV EVSIEAGRMT HNHPIGFLGS LCTALFASFA
     VQGRPLVSWG RELLKTLPKA EEYCRKTIRH MAEYQETWFY FEAKWQFYLE ERGIEDGQSK
     PSFPERYDAD ETDRMYKRWS SEGCAGRRGH DAPMIAYDAL LAAGSDWEEL CRRAILHGGE
     SSATGLISGC LFGLLHGLSA APTGLHQDLD RREKLQDLGE RLYRAAALEK