ID   ARHL1_RAT               Reviewed;         353 AA.
AC   Q5XIB3;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Inactive ADP-ribosyltransferase ARH2 {ECO:0000305};
DE   AltName: Full=ADP-ribosylhydrolase-like protein 1 {ECO:0000305};
DE   AltName: Full=[Protein ADP-ribosylarginine] hydrolase-like protein 1;
GN   Name=Adprhl1; Synonyms=Arh2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for myofibril assembly and outgrowth of the cardiac
CC       chambers in the developing heart (By similarity). Appears to be
CC       catalytically inactive, showing no activity against O-acetyl-ADP-ribose
CC       (By similarity). {ECO:0000250|UniProtKB:Q6AZR2,
CC       ECO:0000250|UniProtKB:Q8BGK2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC       {ECO:0000250|UniProtKB:Q6AZR2}.
CC   -!- SIMILARITY: Belongs to the ADP-ribosylglycohydrolase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Although it belongs to the ADP-ribosylglycohydrolase family,
CC       lacks the metal-binding and substrate-binding residues, suggesting that
CC       it has no hydrolase activity. {ECO:0000250|UniProtKB:Q6AZR2}.
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DR   EMBL; BC083773; AAH83773.1; -; mRNA.
DR   RefSeq; NP_001013072.1; NM_001013054.1.
DR   AlphaFoldDB; Q5XIB3; -.
DR   SMR; Q5XIB3; -.
DR   BioGRID; 253353; 1.
DR   PaxDb; Q5XIB3; -.
DR   PRIDE; Q5XIB3; -.
DR   GeneID; 290880; -.
DR   KEGG; rno:290880; -.
DR   UCSC; RGD:1305641; rat.
DR   CTD; 113622; -.
DR   RGD; 1305641; Adprhl1.
DR   VEuPathDB; HostDB:ENSRNOG00000019504; -.
DR   eggNOG; ENOG502QPMI; Eukaryota.
DR   HOGENOM; CLU_047061_0_0_1; -.
DR   InParanoid; Q5XIB3; -.
DR   OMA; DATLMHM; -.
DR   OrthoDB; 416041at2759; -.
DR   PRO; PR:Q5XIB3; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000062013; Expressed in heart and 9 other tissues.
DR   Genevisible; Q5XIB3; RN.
DR   GO; GO:0030017; C:sarcomere; ISS:UniProtKB.
DR   GO; GO:0003875; F:ADP-ribosylarginine hydrolase activity; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0003242; P:cardiac chamber ballooning; ISS:UniProtKB.
DR   GO; GO:0055003; P:cardiac myofibril assembly; ISS:UniProtKB.
DR   GO; GO:0051725; P:protein de-ADP-ribosylation; IEA:InterPro.
DR   Gene3D; 1.10.4080.10; -; 1.
DR   InterPro; IPR012108; ADP-ribosylarg_hydro.
DR   InterPro; IPR005502; Ribosyl_crysJ1.
DR   InterPro; IPR036705; Ribosyl_crysJ1_sf.
DR   Pfam; PF03747; ADP_ribosyl_GH; 1.
DR   PIRSF; PIRSF016939; ADP_ribslarg_hdr; 1.
DR   SUPFAM; SSF101478; SSF101478; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..353
FT                   /note="Inactive ADP-ribosyltransferase ARH2"
FT                   /id="PRO_0000277609"
FT   MOD_RES         27
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BGK2"
SQ   SEQUENCE   353 AA;  39877 MW;  90BB0D03AF258330 CRC64;
     MEKFKAAMLL GTVGDALGYG NVCRENSASG SIQEELQKTR GLDSLVLSPG KWPVSDNTIM
     HMATAEALTT DYWCLDDLYR EMVKRYVETV EKLSEHRPDP STIEGCSQLK PDNYLLAWHT
     PFSEKGSGFG AATKAMCIGM RYWKPERLET LIEVSIECGR MTHNHPTGFL GSLCTALFAS
     YAIQGKSLVQ WGRDMLKVLP LAEEYCRKSI RHMAEYQEHW FYFEAKWQFY LEERKIREDS
     EVTAVFPDNY DAEERDKTYK KWSSEGRGGR RGHDAPMIAY DALLASGSSW TELCQRAMFH
     RGESGATGTI AGCLFGLLHG LATVPPGLYQ ELEHKGRLED LGTALHRLST EEK