ARI3A_DANRE
ID ARI3A_DANRE Reviewed; 570 AA.
AC A2BEA6;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=AT-rich interactive domain-containing protein 3A;
DE Short=ARID domain-containing protein 3A;
DE AltName: Full=Bright homolog;
GN Name=arid3a; ORFNames=si:ch211-113n10.6;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179; SER-356; SER-542 AND
RP SER-569, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18307296; DOI=10.1021/pr700667w;
RA Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA Slijper M., Heck A.J.R.;
RT "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT analysis down to a single embryo.";
RL J. Proteome Res. 7:1555-1564(2008).
CC -!- FUNCTION: Transcription factor. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}.
CC Cytoplasm {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm.
CC {ECO:0000250}.
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DR EMBL; CR318632; CAM13141.1; -; Genomic_DNA.
DR EMBL; BX005419; CAM13141.1; JOINED; Genomic_DNA.
DR RefSeq; NP_001093509.1; NM_001100039.1.
DR AlphaFoldDB; A2BEA6; -.
DR SMR; A2BEA6; -.
DR STRING; 7955.ENSDARP00000088317; -.
DR iPTMnet; A2BEA6; -.
DR PaxDb; A2BEA6; -.
DR PeptideAtlas; A2BEA6; -.
DR PRIDE; A2BEA6; -.
DR Ensembl; ENSDART00000097546; ENSDARP00000088317; ENSDARG00000067729.
DR Ensembl; ENSDART00000184160; ENSDARP00000146856; ENSDARG00000114447.
DR GeneID; 569444; -.
DR KEGG; dre:569444; -.
DR CTD; 138715; -.
DR ZFIN; ZDB-GENE-060526-12; arid3c.
DR eggNOG; KOG2744; Eukaryota.
DR GeneTree; ENSGT00940000160028; -.
DR HOGENOM; CLU_026952_3_0_1; -.
DR InParanoid; A2BEA6; -.
DR OrthoDB; 1347369at2759; -.
DR PhylomeDB; A2BEA6; -.
DR TreeFam; TF320364; -.
DR PRO; PR:A2BEA6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000067729; Expressed in retina and 15 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.150.60; -; 1.
DR InterPro; IPR045147; ARI3A/B/C.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR023334; REKLES_domain.
DR PANTHER; PTHR15348; PTHR15348; 1.
DR Pfam; PF01388; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SUPFAM; SSF46774; SSF46774; 1.
DR PROSITE; PS51011; ARID; 1.
DR PROSITE; PS51486; REKLES; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..570
FT /note="AT-rich interactive domain-containing protein 3A"
FT /id="PRO_0000295159"
FT DOMAIN 232..324
FT /note="ARID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00355"
FT DOMAIN 429..523
FT /note="REKLES"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00819"
FT REGION 102..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..473
FT /note="Important for nuclear localization"
FT /evidence="ECO:0000250"
FT REGION 475..495
FT /note="Homodimerization"
FT /evidence="ECO:0000250"
FT REGION 519..531
FT /note="Important for cytoplasmic localization"
FT /evidence="ECO:0000250"
FT REGION 528..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..155
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 179
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18307296"
FT MOD_RES 356
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18307296"
FT MOD_RES 542
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18307296"
FT MOD_RES 569
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18307296"
SQ SEQUENCE 570 AA; 62395 MW; 172CEAB0350472E3 CRC64;
MVDNTSIATK SALQAAFSSA SSLPLLVSSP GAHGQSGGGG GMKLEAVMEN LQRQQAARLA
LEEKLRQAEK EKDIRSMVES QIQQQALAFR HYQAAVRGAF AAGVPNSSSG HPLERRAESD
IDDEDDEDDD PELDRGMDDE ERDMDEDDSM NEGGGDEDLE GPLAHYPPRH AVYPGAGQSP
KSTPIHLSRV QPPYPAPRQA ESPSALAPQA QSQHHEWTYE EQFKQLYELD DDEKRKEFLD
DLFSFMQKRG TPVNRIPIMA KQVLDLYTLY KLVTEKGGLV EVINKKIWRE ITKGLNLPTS
ITSAAFTLRT QYMKYLYPYE CEKRGLSSPG ELQAAIDSNR REGRRQSYGS TLFNYSPVGT
PTLLASPKLQ MPHISMPTPN GGHMTQTPGI KKEDSMLSSC LTNRVGIPMS LAGHHSAAQA
AAAAAVQAAA LEQLREKLES GEPPEKKVML MAEEQQRIMQ HALQQNLFAM ATQLPMNIKL
NNRDDRQETA LNLSTNGISS INMSIEINGV VYTGVLFARK PAIGFMPSSQ RVHHQHSSQG
KSNSPGLSSH IQPSSSASSS ASSHGPATSP
