ARI3A_XENTR
ID ARI3A_XENTR Reviewed; 541 AA.
AC Q5XGD9;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=AT-rich interactive domain-containing protein 3A;
DE Short=ARID domain-containing protein 3A;
DE AltName: Full=Bright homolog;
DE AltName: Full=Dead ringer-like protein 1;
GN Name=arid3a; Synonyms=dril1; ORFNames=TNeu118e10.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP IDENTIFICATION, AND FUNCTION.
RX PubMed=15680369; DOI=10.1016/j.ydbio.2004.11.017;
RA Callery E.M., Smith J.C., Thomsen G.H.;
RT "The ARID domain protein dril1 is necessary for TGF(beta) signaling in
RT Xenopus embryos.";
RL Dev. Biol. 278:542-559(2005).
CC -!- FUNCTION: Transcription factor required for smad1 and smad2-mediated
CC responses to TGFbeta during mesoderm induction.
CC {ECO:0000269|PubMed:15680369}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}.
CC Cytoplasm {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm.
CC {ECO:0000250}.
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DR EMBL; CR759981; CAJ82754.1; -; mRNA.
DR EMBL; BC084503; AAH84503.1; -; mRNA.
DR RefSeq; NP_001011106.1; NM_001011106.1.
DR RefSeq; XP_012816175.1; XM_012960721.1.
DR RefSeq; XP_012816184.1; XM_012960730.2.
DR RefSeq; XP_012816186.1; XM_012960732.2.
DR RefSeq; XP_012816189.1; XM_012960735.2.
DR AlphaFoldDB; Q5XGD9; -.
DR SMR; Q5XGD9; -.
DR STRING; 8364.ENSXETP00000056949; -.
DR PaxDb; Q5XGD9; -.
DR DNASU; 496519; -.
DR GeneID; 496519; -.
DR KEGG; xtr:496519; -.
DR CTD; 1820; -.
DR Xenbase; XB-GENE-945264; arid3a.
DR eggNOG; KOG2744; Eukaryota.
DR HOGENOM; CLU_026952_3_0_1; -.
DR InParanoid; Q5XGD9; -.
DR OrthoDB; 1347369at2759; -.
DR PhylomeDB; Q5XGD9; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000021613; Expressed in neurula embryo and 11 other tissues.
DR ExpressionAtlas; Q5XGD9; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.150.60; -; 1.
DR InterPro; IPR045147; ARI3A/B/C.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR023334; REKLES_domain.
DR PANTHER; PTHR15348; PTHR15348; 1.
DR Pfam; PF01388; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SUPFAM; SSF46774; SSF46774; 1.
DR PROSITE; PS51011; ARID; 1.
DR PROSITE; PS51486; REKLES; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..541
FT /note="AT-rich interactive domain-containing protein 3A"
FT /id="PRO_0000295161"
FT DOMAIN 212..304
FT /note="ARID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00355"
FT DOMAIN 407..501
FT /note="REKLES"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00819"
FT REGION 17..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..450
FT /note="Important for nuclear localization"
FT /evidence="ECO:0000250"
FT REGION 452..473
FT /note="Homodimerization"
FT /evidence="ECO:0000250"
FT REGION 497..504
FT /note="Important for cytoplasmic localization"
FT /evidence="ECO:0000250"
FT REGION 499..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..104
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..145
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..541
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 541 AA; 58757 MW; 9BB6BD53266FA71E CRC64;
MKLQAVMETL QRQQRARLQQ ELEARQLQQD SSEGRTPPSV GYPGNGSEEA EPEALKIQRA
QAAALAAMRA AAAGLSQQPS PAASDEEEED GESMASDEED EKERDGESER YPDMGSEEED
LKGKWDEDDF EDEGEEDDYE DMEEGMGVSE AGRVGKGSTL PPKHPNPQAF PTQRSVGAER
AGLPHTGHPQ LQDHGDWTYE EQFKQLYELD GDPKRKEFLD DLFSFMQKRG TPVNRIPIMA
KQVLDLYMLY VLVTEKGGLV EVINKKLWRE ITKGLNLPTS ITSAAFTLRT QYMKYLYPYE
CEKRGLSNPN ELQAAIDSNR REGRRQSFGG SLFTYSPSGA PSMLSSPKLQ VSALSLGGVA
TNGSSLSSMQ KIKKEEDSPI SLTVPPRIPV SLAGHSMVAA QVAAQAAALE QLREKLESGE
PPEKKMALGT EEQQRLQRAI QHNLLAMTAQ LPMNIRINSQ AEGRQDSAVN LTTNGTNSIS
MSVELNGIVY TGVLFAQPPT SASGTSKGSS NRTGSIGGGS STSQAAPPPA PSAPTSNNPS
P
