ARI3C_HUMAN
ID ARI3C_HUMAN Reviewed; 412 AA.
AC A6NKF2;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=AT-rich interactive domain-containing protein 3C;
DE Short=ARID domain-containing protein 3C;
GN Name=ARID3C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP IDENTIFICATION.
RX PubMed=17400556; DOI=10.1074/jbc.m700397200;
RA Kim D., Probst L., Das C., Tucker P.W.;
RT "REKLES is an ARID3-restricted multifunctional domain.";
RL J. Biol. Chem. 282:15768-15777(2007).
CC -!- INTERACTION:
CC A6NKF2; Q9NWQ9: C14orf119; NbExp=3; IntAct=EBI-12805486, EBI-725606;
CC A6NKF2; O00257-3: CBX4; NbExp=3; IntAct=EBI-12805486, EBI-4392727;
CC A6NKF2; P78317: RNF4; NbExp=3; IntAct=EBI-12805486, EBI-2340927;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}.
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DR EMBL; AL450283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS35006.1; -.
DR RefSeq; NP_001017363.1; NM_001017363.1.
DR AlphaFoldDB; A6NKF2; -.
DR SMR; A6NKF2; -.
DR BioGRID; 126518; 10.
DR IntAct; A6NKF2; 4.
DR STRING; 9606.ENSP00000368189; -.
DR iPTMnet; A6NKF2; -.
DR PhosphoSitePlus; A6NKF2; -.
DR BioMuta; ARID3C; -.
DR jPOST; A6NKF2; -.
DR MassIVE; A6NKF2; -.
DR MaxQB; A6NKF2; -.
DR PaxDb; A6NKF2; -.
DR PeptideAtlas; A6NKF2; -.
DR PRIDE; A6NKF2; -.
DR ProteomicsDB; 1410; -.
DR Antibodypedia; 25532; 54 antibodies from 18 providers.
DR DNASU; 138715; -.
DR Ensembl; ENST00000378909.3; ENSP00000368189.2; ENSG00000205143.4.
DR GeneID; 138715; -.
DR KEGG; hsa:138715; -.
DR MANE-Select; ENST00000378909.4; ENSP00000368189.2; NM_001017363.4; NP_001017363.1.
DR UCSC; uc011lon.3; human.
DR CTD; 138715; -.
DR GeneCards; ARID3C; -.
DR HGNC; HGNC:21209; ARID3C.
DR HPA; ENSG00000205143; Tissue enriched (liver).
DR neXtProt; NX_A6NKF2; -.
DR OpenTargets; ENSG00000205143; -.
DR PharmGKB; PA134928507; -.
DR VEuPathDB; HostDB:ENSG00000205143; -.
DR eggNOG; KOG2744; Eukaryota.
DR GeneTree; ENSGT00940000160028; -.
DR HOGENOM; CLU_026952_1_0_1; -.
DR InParanoid; A6NKF2; -.
DR OMA; RHAYTAT; -.
DR OrthoDB; 1347369at2759; -.
DR PhylomeDB; A6NKF2; -.
DR TreeFam; TF320364; -.
DR PathwayCommons; A6NKF2; -.
DR SignaLink; A6NKF2; -.
DR BioGRID-ORCS; 138715; 20 hits in 1090 CRISPR screens.
DR GenomeRNAi; 138715; -.
DR Pharos; A6NKF2; Tdark.
DR PRO; PR:A6NKF2; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; A6NKF2; protein.
DR Bgee; ENSG00000205143; Expressed in right lobe of liver and 44 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0045121; C:membrane raft; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.150.60; -; 1.
DR InterPro; IPR045147; ARI3A/B/C.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR023334; REKLES_domain.
DR PANTHER; PTHR15348; PTHR15348; 1.
DR Pfam; PF01388; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SUPFAM; SSF46774; SSF46774; 1.
DR PROSITE; PS51011; ARID; 1.
DR PROSITE; PS51486; REKLES; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..412
FT /note="AT-rich interactive domain-containing protein 3C"
FT /id="PRO_0000333001"
FT DOMAIN 113..205
FT /note="ARID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00355"
FT DOMAIN 304..389
FT /note="REKLES"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00819"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..68
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..261
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..412
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 310
FT /note="R -> Q (in dbSNP:rs12337871)"
FT /id="VAR_043033"
FT VARIANT 335
FT /note="C -> G (in dbSNP:rs3808869)"
FT /id="VAR_043034"
SQ SEQUENCE 412 AA; 44073 MW; A4F27053248A49A7 CRC64;
MEALQKQQAA RLAQGVGPLA PACPLLPPQP PLPDHRTLQA PEGALGNVGA EEEEDAEEDE
EKREEAGAEE EAAEESRPGA QGPSSPSSQP PGLHPHEWTY EEQFKQLYEL DADPKRKEFL
DDLFSFMQKR GTPVNRVPIM AKQVLDLYAL FRLVTAKGGL VEVINRKVWR EVTRGLSLPT
TITSAAFTLR TQYMKYLYPY ECETRALSSP GELQAAIDSN RREGRRQAYT ATPLFGLAGP
PPRGAQDPAL GPGPAPPATQ SSPGPAQGST SGLPAHACAQ LSPSPIKKEE SGIPNPCLAL
PVGLALGPTR EKLAPEEPPE KRAVLMGPMD PPRPCMPPSF LPRGKVPLRE ERLDGPLNLA
GSGISSINMA LEINGVVYTG VLFARRQPVP ASQGPTNPAP PPSTGPPSSI LP
