MENG_THEVB
ID MENG_THEVB Reviewed; 225 AA.
AC Q8DGE4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=2-phytyl-1,4-naphtoquinone methyltransferase {ECO:0000255|HAMAP-Rule:MF_01982};
DE EC=2.1.1.329 {ECO:0000255|HAMAP-Rule:MF_01982};
DE AltName: Full=Demethylphylloquinone methyltransferase {ECO:0000255|HAMAP-Rule:MF_01982};
GN Name=menG {ECO:0000255|HAMAP-Rule:MF_01982}; OrderedLocusNames=tll2373;
OS Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1).
OC Bacteria; Cyanobacteria; Pseudanabaenales; Thermosynechococcaceae;
OC Thermosynechococcus.
OX NCBI_TaxID=197221;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-2133 / IAM M-273 / BP-1;
RX PubMed=12240834; DOI=10.1093/dnares/9.4.123;
RA Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S.,
RA Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C.,
RA Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M.,
RA Takeuchi C., Yamada M., Tabata S.;
RT "Complete genome structure of the thermophilic cyanobacterium
RT Thermosynechococcus elongatus BP-1.";
RL DNA Res. 9:123-130(2002).
CC -!- FUNCTION: Methyltransferase required for the conversion of 2-phytyl-
CC 1,4-beta-naphthoquinol to phylloquinol. {ECO:0000255|HAMAP-
CC Rule:MF_01982}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=demethylphylloquinol + S-adenosyl-L-methionine = H(+) +
CC phylloquinol + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:40551,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:28433, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:87844; EC=2.1.1.329;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01982};
CC -!- PATHWAY: Cofactor biosynthesis; phylloquinone biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_01982}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. MenG/UbiE family. {ECO:0000255|HAMAP-Rule:MF_01982}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000039; BAC09925.1; -; Genomic_DNA.
DR RefSeq; NP_683163.1; NC_004113.1.
DR RefSeq; WP_011058206.1; NC_004113.1.
DR AlphaFoldDB; Q8DGE4; -.
DR SMR; Q8DGE4; -.
DR STRING; 197221.22296101; -.
DR EnsemblBacteria; BAC09925; BAC09925; BAC09925.
DR KEGG; tel:tll2373; -.
DR PATRIC; fig|197221.4.peg.2490; -.
DR eggNOG; COG2226; Bacteria.
DR OMA; WQKSALN; -.
DR OrthoDB; 1431378at2; -.
DR UniPathway; UPA00995; -.
DR Proteomes; UP000000440; Chromosome.
DR GO; GO:0052624; F:2-phytyl-1,4-naphthoquinone methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0042372; P:phylloquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.150; -; 1.
DR HAMAP; MF_01982; MenG_phylloquinone_subfam; 1.
DR HAMAP; MF_01813; MenG_UbiE_methyltr; 1.
DR InterPro; IPR032904; MenG.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR Pfam; PF01209; Ubie_methyltran; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
DR TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR PROSITE; PS51608; SAM_MT_UBIE; 1.
DR PROSITE; PS01183; UBIE_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW Transferase.
FT CHAIN 1..225
FT /note="2-phytyl-1,4-naphtoquinone methyltransferase"
FT /id="PRO_0000193340"
SQ SEQUENCE 225 AA; 25250 MW; E86BA421A93D2F15 CRC64;
MTNIQALFER IAPLYDRLND QLSFGLHHVW KQMAVDWLEL PQGATALDLC CGTGDLTRLL
ARRVGRQGRV VGLDFAAAPL AIARQRSDHY PQIEWLQGDA LAVPFAPQTF QGITIGYGLR
NVVDIPQALR EMFRLLVPGG RAAILDFSHP QTSALEQFQQ WYLQQWVVPT ARHYGLAAEY
DYLWPSIQAF PTPPTLCALI QQAGFERVKH YPLLGGLMAI TVAQK
