ARI3C_MOUSE
ID ARI3C_MOUSE Reviewed; 409 AA.
AC A6PWV5; B2RUN0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=AT-rich interactive domain-containing protein 3C;
DE Short=ARID domain-containing protein 3C;
GN Name=Arid3c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM16056.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL807796; CAM16056.2; ALT_SEQ; Genomic_DNA.
DR EMBL; BC141237; AAI41238.1; -; mRNA.
DR CCDS; CCDS38719.1; -.
DR RefSeq; NP_001017362.1; NM_001017362.2.
DR AlphaFoldDB; A6PWV5; -.
DR SMR; A6PWV5; -.
DR STRING; 10090.ENSMUSP00000127678; -.
DR PhosphoSitePlus; A6PWV5; -.
DR PaxDb; A6PWV5; -.
DR PRIDE; A6PWV5; -.
DR Antibodypedia; 25532; 54 antibodies from 18 providers.
DR DNASU; 550619; -.
DR Ensembl; ENSMUST00000084698; ENSMUSP00000081748; ENSMUSG00000066224.
DR Ensembl; ENSMUST00000171251; ENSMUSP00000127678; ENSMUSG00000066224.
DR GeneID; 550619; -.
DR KEGG; mmu:550619; -.
DR UCSC; uc008sjj.1; mouse.
DR CTD; 138715; -.
DR MGI; MGI:3650624; Arid3c.
DR VEuPathDB; HostDB:ENSMUSG00000066224; -.
DR eggNOG; KOG2744; Eukaryota.
DR GeneTree; ENSGT00940000160028; -.
DR HOGENOM; CLU_026952_1_0_1; -.
DR InParanoid; A6PWV5; -.
DR OMA; RHAYTAT; -.
DR OrthoDB; 1347369at2759; -.
DR PhylomeDB; A6PWV5; -.
DR TreeFam; TF320364; -.
DR BioGRID-ORCS; 550619; 5 hits in 74 CRISPR screens.
DR PRO; PR:A6PWV5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A6PWV5; protein.
DR Bgee; ENSMUSG00000066224; Expressed in secondary oocyte and 14 other tissues.
DR ExpressionAtlas; A6PWV5; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0045121; C:membrane raft; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.150.60; -; 1.
DR InterPro; IPR045147; ARI3A/B/C.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR023334; REKLES_domain.
DR PANTHER; PTHR15348; PTHR15348; 1.
DR Pfam; PF01388; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SUPFAM; SSF46774; SSF46774; 1.
DR PROSITE; PS51011; ARID; 1.
DR PROSITE; PS51486; REKLES; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..409
FT /note="AT-rich interactive domain-containing protein 3C"
FT /id="PRO_0000333002"
FT DOMAIN 110..202
FT /note="ARID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00355"
FT DOMAIN 301..386
FT /note="REKLES"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00819"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..66
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..409
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 409 AA; 43633 MW; 10F988A18035F971 CRC64;
MEALQRQQAA RLAQGVGPLA PPRLPLPQPP LLGARTLQAP EGAIGVVGAE EEEGAEDEEG
ETPLAEEETA EQSHPGARCP NSPSSQSPGI QPHEWTYEEQ FKQLYELDAD PKRKEFLDDL
FSFMQKRGTP VNRVPIMAKQ VLDLYALFRL VTAKGGLVEV INRKVWREVT RGLSLPTTIT
SAAFTLRTQY MKYLYPYECE TRALSSPGEL QAAIDSNRRE GRRQAYTAVP LFNLAGPTPR
GAPGPASSHG PAPTATPNCP GPTQGSASGL PAHACAQLSP SPVKKEESGI PPPRLALPMG
LASEATREKL APEEPPEKRA VLMGPVDSPR LGAPPSFLPR GKAPLREERL DGPLNLAGSG
ISSINVALEI NGVVYTGILF ARRQPVPASL GPTNPPPLPS TGPPSSTLP
