MENT_HUMAN
ID MENT_HUMAN Reviewed; 341 AA.
AC Q9BUN1; B2RDU8; Q9NWZ4;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein MENT;
DE AltName: Full=Methylated in normal thymocytes protein;
DE Flags: Precursor;
GN Name=MENT; Synonyms=C1orf56; ORFNames=UNQ547/PRO1104;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Signet-ring cell carcinoma, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=22133874; DOI=10.1172/jci57292;
RA Hlady R.A., Novakova S., Opavska J., Klinkebiel D., Peters S.L., Bies J.,
RA Hannah J., Iqbal J., Anderson K.M., Siebler H.M., Smith L.M., Greiner T.C.,
RA Bastola D., Joshi S., Lockridge O., Simpson M.A., Felsher D.W.,
RA Wagner K.U., Chan W.C., Christman J.K., Opavsky R.;
RT "Loss of Dnmt3b function upregulates the tumor modifier Ment and
RT accelerates mouse lymphomagenesis.";
RL J. Clin. Invest. 122:163-177(2012).
CC -!- FUNCTION: Involved in control of cellular proliferation. Onconcogenic
CC modifier contributing to the tumor suppressor function of DNMT3B.
CC {ECO:0000269|PubMed:22133874}.
CC -!- INTERACTION:
CC Q9BUN1; Q5RI15: COX20; NbExp=3; IntAct=EBI-12022316, EBI-2834035;
CC Q9BUN1; O43186: CRX; NbExp=3; IntAct=EBI-12022316, EBI-748171;
CC Q9BUN1; Q0VD86: INCA1; NbExp=3; IntAct=EBI-12022316, EBI-6509505;
CC Q9BUN1; Q04864-2: REL; NbExp=3; IntAct=EBI-12022316, EBI-10829018;
CC Q9BUN1; P15884-3: TCF4; NbExp=3; IntAct=EBI-12022316, EBI-13636688;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BUN1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BUN1-2; Sequence=VSP_028157, VSP_028158;
CC -!- TISSUE SPECIFICITY: Plasma. Overexpressed in lymphomas.
CC {ECO:0000269|PubMed:22133874}.
CC -!- PTM: Phosphorylation sites are present in the extracellular medium.
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DR EMBL; AY358436; AAQ88802.1; -; mRNA.
DR EMBL; AK000526; BAA91231.1; -; mRNA.
DR EMBL; AK315680; BAG38045.1; -; mRNA.
DR EMBL; AL590133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471121; EAW53481.1; -; Genomic_DNA.
DR EMBL; BC002469; AAH02469.1; -; mRNA.
DR CCDS; CCDS980.1; -. [Q9BUN1-1]
DR RefSeq; NP_060330.2; NM_017860.4. [Q9BUN1-1]
DR AlphaFoldDB; Q9BUN1; -.
DR SMR; Q9BUN1; -.
DR BioGRID; 120302; 5.
DR IntAct; Q9BUN1; 6.
DR STRING; 9606.ENSP00000357922; -.
DR GlyGen; Q9BUN1; 5 sites, 3 O-linked glycans (5 sites).
DR iPTMnet; Q9BUN1; -.
DR PhosphoSitePlus; Q9BUN1; -.
DR BioMuta; C1orf56; -.
DR DMDM; 74752360; -.
DR jPOST; Q9BUN1; -.
DR MassIVE; Q9BUN1; -.
DR PaxDb; Q9BUN1; -.
DR PeptideAtlas; Q9BUN1; -.
DR PRIDE; Q9BUN1; -.
DR ProteomicsDB; 79111; -. [Q9BUN1-1]
DR ProteomicsDB; 79112; -. [Q9BUN1-2]
DR Antibodypedia; 49641; 69 antibodies from 14 providers.
DR DNASU; 54964; -.
DR Ensembl; ENST00000368926.6; ENSP00000357922.5; ENSG00000143443.10. [Q9BUN1-1]
DR GeneID; 54964; -.
DR KEGG; hsa:54964; -.
DR MANE-Select; ENST00000368926.6; ENSP00000357922.5; NM_017860.5; NP_060330.2.
DR UCSC; uc001ewn.4; human. [Q9BUN1-1]
DR CTD; 54964; -.
DR DisGeNET; 54964; -.
DR GeneCards; C1orf56; -.
DR HGNC; HGNC:26045; C1orf56.
DR HPA; ENSG00000143443; Tissue enriched (testis).
DR neXtProt; NX_Q9BUN1; -.
DR OpenTargets; ENSG00000143443; -.
DR PharmGKB; PA142672507; -.
DR VEuPathDB; HostDB:ENSG00000143443; -.
DR eggNOG; ENOG502SZ3R; Eukaryota.
DR GeneTree; ENSGT00390000014288; -.
DR HOGENOM; CLU_066649_0_0_1; -.
DR InParanoid; Q9BUN1; -.
DR OMA; WHCHCRS; -.
DR OrthoDB; 1015642at2759; -.
DR PhylomeDB; Q9BUN1; -.
DR TreeFam; TF338845; -.
DR PathwayCommons; Q9BUN1; -.
DR SignaLink; Q9BUN1; -.
DR BioGRID-ORCS; 54964; 21 hits in 1070 CRISPR screens.
DR ChiTaRS; C1orf56; human.
DR GenomeRNAi; 54964; -.
DR Pharos; Q9BUN1; Tbio.
DR PRO; PR:Q9BUN1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9BUN1; protein.
DR Bgee; ENSG00000143443; Expressed in left testis and 152 other tissues.
DR Genevisible; Q9BUN1; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042127; P:regulation of cell population proliferation; IMP:UniProtKB.
DR InterPro; IPR029292; MENT.
DR PANTHER; PTHR16240; PTHR16240; 1.
DR Pfam; PF15322; PMSI1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..341
FT /note="Protein MENT"
FT /id="PRO_0000304969"
FT REGION 115..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 167..176
FT /note="GSQATLSQWS -> CHLLRICGWC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028157"
FT VAR_SEQ 177..341
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028158"
SQ SEQUENCE 341 AA; 36769 MW; F3C6BAE1C30F6CA3 CRC64;
MVPAAGALLW VLLLNLGPRA AGAQGLTQTP TEMQRVSLRF GGPMTRSYRS TARTGLPRKT
RIILEDENDA MADADRLAGP AAAELLAATV STGFSRSSAI NEEDGSSEEG VVINAGKDST
SRELPSATPN TAGSSSTRFI ANSQEPEIRL TSSLPRSPGR STEDLPGSQA TLSQWSTPGS
TPSRWPSPSP TAMPSPEDLR LVLMPWGPWH CHCKSGTMSR SRSGKLHGLS GRLRVGALSQ
LRTEHKPCTY QQCPCNRLRE ECPLDTSLCT DTNCASQSTT STRTTTTPFP TIHLRSSPSL
PPASPCPALA FWKRVRIGLE DIWNSLSSVF TEMQPIDRNQ R
