ID   MENT_MOUSE              Reviewed;         350 AA.
AC   Q569E4;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Protein MENT;
DE   AltName: Full=Methylated in normal thymocytes protein;
DE   Flags: Precursor;
GN   Name=Ment; Synonyms=Gm128;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Lung;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4]
RP   TISSUE SPECIFICITY, AND FUNCTION.
RX   PubMed=22133874; DOI=10.1172/jci57292;
RA   Hlady R.A., Novakova S., Opavska J., Klinkebiel D., Peters S.L., Bies J.,
RA   Hannah J., Iqbal J., Anderson K.M., Siebler H.M., Smith L.M., Greiner T.C.,
RA   Bastola D., Joshi S., Lockridge O., Simpson M.A., Felsher D.W.,
RA   Wagner K.U., Chan W.C., Christman J.K., Opavsky R.;
RT   "Loss of Dnmt3b function upregulates the tumor modifier Ment and
RT   accelerates mouse lymphomagenesis.";
RL   J. Clin. Invest. 122:163-177(2012).
RN   [5]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=22621904; DOI=10.1091/mbc.e11-12-1025;
RA   Yamaguchi R., Fujihara Y., Ikawa M., Okabe M.;
RT   "Mice expressing aberrant sperm-specific protein PMIS2 produce normal-
RT   looking but fertilization-incompetent spermatozoa.";
RL   Mol. Biol. Cell 23:2671-2679(2012).
CC   -!- FUNCTION: Involved in control of cellular proliferation. Onconcogenic
CC       modifier contributing to the tumor suppressor function of DNMT3B.
CC       {ECO:0000269|PubMed:22133874}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: High expression in testis, but low in other
CC       tissues. {ECO:0000269|PubMed:22133874}.
CC   -!- PTM: Phosphorylation sites are present in the extracellular medium.
CC       {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype. Mice lacking Ment are
CC       viable and have no overt fertility phenotype.
CC       {ECO:0000269|PubMed:22621904}.
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DR   EMBL; AK144488; BAE25915.1; -; mRNA.
DR   EMBL; BC092540; AAH92540.1; -; mRNA.
DR   CCDS; CCDS17608.1; -.
DR   RefSeq; NP_001020012.1; NM_001024841.3.
DR   AlphaFoldDB; Q569E4; -.
DR   STRING; 10090.ENSMUSP00000088324; -.
DR   PhosphoSitePlus; Q569E4; -.
DR   PaxDb; Q569E4; -.
DR   PRIDE; Q569E4; -.
DR   ProteomicsDB; 295855; -.
DR   Antibodypedia; 49641; 69 antibodies from 14 providers.
DR   Ensembl; ENSMUST00000090815; ENSMUSP00000088324; ENSMUSG00000068860.
DR   GeneID; 229588; -.
DR   KEGG; mmu:229588; -.
DR   UCSC; uc008qiw.1; mouse.
DR   MGI; MGI:2684974; Gm128.
DR   VEuPathDB; HostDB:ENSMUSG00000068860; -.
DR   eggNOG; ENOG502SZ3R; Eukaryota.
DR   GeneTree; ENSGT00390000014288; -.
DR   InParanoid; Q569E4; -.
DR   OMA; WHCHCRS; -.
DR   OrthoDB; 1015642at2759; -.
DR   TreeFam; TF338845; -.
DR   BioGRID-ORCS; 229588; 1 hit in 64 CRISPR screens.
DR   ChiTaRS; Gm128; mouse.
DR   PRO; PR:Q569E4; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q569E4; protein.
DR   Bgee; ENSMUSG00000068860; Expressed in spermatid and 32 other tissues.
DR   ExpressionAtlas; Q569E4; baseline and differential.
DR   Genevisible; Q569E4; MM.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IMP:UniProtKB.
DR   InterPro; IPR029292; MENT.
DR   PANTHER; PTHR16240; PTHR16240; 1.
DR   Pfam; PF15322; PMSI1; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..350
FT                   /note="Protein MENT"
FT                   /id="PRO_0000304970"
SQ   SEQUENCE   350 AA;  38118 MW;  C3E6E49D6EAEADF4 CRC64;
     MVPAACMLLW ALLLSLEYRA AGAEDQTTTP TATTIGMQRV SFRFGGPARS LHSTNPTART
     TVPGKLRVTL EDENDALATA DRLALPAAAE LLSTVTGYSR SSVPSPSDWE EDGSLEEGVV
     DTRKTTNGPV SLFSTTNTVG SSGTTGRFLA NSQEREIKLT TDVRSLSSKT TVVDLSSEST
     LQQWSTPGST PSPWLKPSFT AMPSPEDLRV VLMPWGPWHC HCKSGTMSRS RAGKLHGLSG
     RLRVGALNEL RTEHRPCTYQ LCACNRHLEE CPLDSSLCSD HSCSSRAPFQ SSTTSLVPVH
     LRRRPILPPT SPSPSPALAF WKRVRIGLED IWNSLSSVFT ETQPVERIQR