ID   MEOX1_PANPA             Reviewed;         254 AA.
AC   A1YGA4;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Homeobox protein MOX-1;
DE   AltName: Full=Mesenchyme homeobox 1;
GN   Name=MEOX1;
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mesodermal transcription factor that plays a key role in
CC       somitogenesis and is specifically required for sclerotome development.
CC       Required for maintenance of the sclerotome polarity and formation of
CC       the cranio-cervical joints. Binds specifically to the promoter of
CC       target genes and regulates their expression. Activates expression of
CC       NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in
CC       endothelial cells, acting as a regulator of vascular cell
CC       proliferation. While it activates CDKN1A in a DNA-dependent manner, it
CC       activates CDKN2A in a DNA-independent manner. Required for
CC       hematopoietic stem cell (HSCs) induction via its role in somitogenesis:
CC       specification of HSCs occurs via the deployment of a specific
CC       endothelial precursor population, which arises within a sub-compartment
CC       of the somite named endotome. {ECO:0000250|UniProtKB:F1Q4R9,
CC       ECO:0000250|UniProtKB:P32442}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P32442}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P32442}. Note=Localizes predominantly in the
CC       nucleus. {ECO:0000250|UniProtKB:P32442}.
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DR   EMBL; DQ977248; ABM54329.1; -; Genomic_DNA.
DR   RefSeq; XP_003806130.1; XM_003806082.2.
DR   AlphaFoldDB; A1YGA4; -.
DR   SMR; A1YGA4; -.
DR   STRING; 9597.XP_003806130.1; -.
DR   Ensembl; ENSPPAT00000053565; ENSPPAP00000030702; ENSPPAG00000038321.
DR   GeneID; 100979862; -.
DR   KEGG; pps:100979862; -.
DR   CTD; 4222; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000154018; -.
DR   OMA; CMRSPQP; -.
DR   OrthoDB; 1522857at2759; -.
DR   Proteomes; UP000240080; Chromosome 17.
DR   Bgee; ENSPPAG00000038321; Expressed in heart and 2 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0071837; F:HMG box domain binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0060218; P:hematopoietic stem cell differentiation; ISS:UniProtKB.
DR   GO; GO:0061056; P:sclerotome development; ISS:UniProtKB.
DR   GO; GO:0061053; P:somite development; ISS:UniProtKB.
DR   GO; GO:0001757; P:somite specification; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR042634; MOX-1/MOX-2.
DR   PANTHER; PTHR24328; PTHR24328; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; Developmental protein; DNA-binding; Homeobox;
KW   Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..254
FT                   /note="Homeobox protein MOX-1"
FT                   /id="PRO_0000285455"
FT   DNA_BIND        171..230
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          87..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..178
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..254
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   254 AA;  28009 MW;  D4AC71F5027ACDD7 CRC64;
     MDPAASSCMR SLQPPAPVWG CLRNPHSEGN GASGLPHYPP TPFSFHQKPD FPATATAAYP
     DFSASCLAAT PHSLPQEEHI FTEQHPVFPQ SPNWHFPVSD ARRRPNSGPA GGSKEMGTSS
     LGLVDTTGGP GEDYGVLGST ANETEKKSSR RRKESSDNQE NRGKPEGSSK ARKERTAFTK
     EQLRELEAEF AHHNYLTRLR RYEIAVNLDL SERQVKVWFQ NRRMKWKRVK GGQPVSPNGQ
     DPEDGDSTAS PSSE