MEOX1_PANTR
ID MEOX1_PANTR Reviewed; 254 AA.
AC A2T779;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 02-JUN-2021, entry version 74.
DE RecName: Full=Homeobox protein MOX-1;
DE AltName: Full=Mesenchyme homeobox 1;
GN Name=MEOX1;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT "Positive selection in transcription factor genes on the human lineage.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mesodermal transcription factor that plays a key role in
CC somitogenesis and is specifically required for sclerotome development.
CC Required for maintenance of the sclerotome polarity and formation of
CC the cranio-cervical joints. Binds specifically to the promoter of
CC target genes and regulates their expression. Activates expression of
CC NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in
CC endothelial cells, acting as a regulator of vascular cell
CC proliferation. While it activates CDKN1A in a DNA-dependent manner, it
CC activates CDKN2A in a DNA-independent manner. Required for
CC hematopoietic stem cell (HSCs) induction via its role in somitogenesis:
CC specification of HSCs occurs via the deployment of a specific
CC endothelial precursor population, which arises within a sub-compartment
CC of the somite named endotome. {ECO:0000250|UniProtKB:F1Q4R9,
CC ECO:0000250|UniProtKB:P32442}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P32442}. Cytoplasm
CC {ECO:0000250|UniProtKB:P32442}. Note=Localizes predominantly in the
CC nucleus. {ECO:0000250|UniProtKB:P32442}.
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DR EMBL; DQ977390; ABM92034.1; -; Genomic_DNA.
DR STRING; 9598.ENSPTRP00000015740; -.
DR PaxDb; A2T779; -.
DR eggNOG; KOG0489; Eukaryota.
DR InParanoid; A2T779; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0060218; P:hematopoietic stem cell differentiation; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0061056; P:sclerotome development; ISS:UniProtKB.
DR GO; GO:0061053; P:somite development; ISS:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR042634; MOX-1/MOX-2.
DR PANTHER; PTHR24328; PTHR24328; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; Developmental protein; DNA-binding; Homeobox;
KW Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..254
FT /note="Homeobox protein MOX-1"
FT /id="PRO_0000285456"
FT DNA_BIND 171..230
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 86..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 254 AA; 27936 MW; 13A0D4C38A3E987D CRC64;
MDPAASSCMR SLQPPAPVWG CLRNPHSEGN GASGLPHYPP TPFSFHXXPD FPATATAAYP
DFSASCLAAT PHSLPQEEHI FTEQHPAFPQ SPNWHFPVSX ARRRPNSGPA GGSKEMGTSS
LGLVDTTGGP GEDYGVLGST ANXXEKKSSR RRKESSDNQE NRGKPEGSSK ARKERTAFTK
EQLRELEAEF AHHNYLTRLR RYEIAVNLDL SERQVKVWFQ NRRMKWKRVK GGQPVSPNGQ
DPEDGDSTAS PSSE