MEOX2_HUMAN
ID MEOX2_HUMAN Reviewed; 304 AA.
AC P50222; A4D127; B2R8I7; O75263; Q9UPL6;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2006, sequence version 2.
DT 03-AUG-2022, entry version 190.
DE RecName: Full=Homeobox protein MOX-2 {ECO:0000303|PubMed:7607679};
DE AltName: Full=Growth arrest-specific homeobox {ECO:0000303|PubMed:7713505};
DE AltName: Full=Mesenchyme homeobox 2 {ECO:0000303|PubMed:7607679};
GN Name=MEOX2 {ECO:0000303|PubMed:16335786, ECO:0000312|HGNC:HGNC:7014};
GN Synonyms=GAX {ECO:0000303|PubMed:7713505},
GN MOX2 {ECO:0000303|PubMed:7607679};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT HIS-80 DEL.
RC TISSUE=Embryo;
RX PubMed=7607679; DOI=10.1016/0888-7543(95)80174-k;
RA Grigoriou M., Kastrinaki M.-C., Modi W., Theodorakis K., Mankoo B.,
RA Pachnis V., Karagogeos D.;
RT "Isolation of the human MOX2 homeobox gene and localization to chromosome
RT 7p22.1-p21.3.";
RL Genomics 26:550-555(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT 79-HIS-HIS-80 DEL.
RC TISSUE=Heart;
RX PubMed=7713505; DOI=10.1006/geno.1994.1663;
RA Lepage D.F., Walsh K.;
RT "Molecular cloning and localization of the human GAX gene to 7p21.";
RL Genomics 24:535-540(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT HIS-80 DEL.
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT HIS-80 DEL.
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT HIS-80 DEL.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP INTERACTION WITH RNF10.
RX PubMed=16335786; DOI=10.1007/s11010-005-0823-3;
RA Lin J., Friesen M.T., Bocangel P., Cheung D., Rawszer K., Wigle J.T.;
RT "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor
RT binding to RING finger protein 10.";
RL Mol. Cell. Biochem. 275:75-84(2005).
RN [8]
RP FUNCTION.
RX PubMed=17074759; DOI=10.1074/jbc.m606604200;
RA Chen Y., Leal A.D., Patel S., Gorski D.H.;
RT "The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular
RT endothelial cells through direct interaction with upstream AT-rich
RT sequences.";
RL J. Biol. Chem. 282:507-517(2007).
RN [9]
RP POLY-HIS POLYMORPHISM.
RX PubMed=19760604; DOI=10.1002/gcc.20705;
RA Ohshima J., Haruta M., Arai Y., Kasai F., Fujiwara Y., Ariga T., Okita H.,
RA Fukuzawa M., Hata J., Horie H., Kaneko Y.;
RT "Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified in a
RT 7p21 homozygous deletion region in a Wilms tumor.";
RL Genes Chromosomes Cancer 48:1037-1050(2009).
RN [10]
RP SUBCELLULAR LOCATION.
RX PubMed=19266028; DOI=10.1371/journal.pgen.1000397;
RA Salichs E., Ledda A., Mularoni L., Alba M.M., de la Luna S.;
RT "Genome-wide analysis of histidine repeats reveals their role in the
RT localization of human proteins to the nuclear speckles compartment.";
RL PLoS Genet. 5:E1000397-E1000397(2009).
RN [11]
RP FUNCTION, AND INDUCTION.
RX PubMed=20516212; DOI=10.1128/mcb.01237-09;
RA Chen Y., Banda M., Speyer C.L., Smith J.S., Rabson A.B., Gorski D.H.;
RT "Regulation of the expression and activity of the antiangiogenic homeobox
RT gene GAX/MEOX2 by ZEB2 and microRNA-221.";
RL Mol. Cell. Biol. 30:3902-3913(2010).
RN [12]
RP FUNCTION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF GLN-236.
RX PubMed=22206000; DOI=10.1371/journal.pone.0029099;
RA Douville J.M., Cheung D.Y., Herbert K.L., Moffatt T., Wigle J.T.;
RT "Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase
RT inhibitors p21 and p16 in vascular endothelial cells.";
RL PLoS ONE 6:E29099-E29099(2011).
CC -!- FUNCTION: Mesodermal transcription factor that plays a key role in
CC somitogenesis and somitogenesis and limb muscle differentiation (By
CC similarity). Required during limb development for normal appendicular
CC muscle formation and for the normal regulation of myogenic genes (By
CC similarity). May have a regulatory role when quiescent vascular smooth
CC muscle cells reenter the cell cycle (By similarity). Also acts as a
CC negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212,
CC PubMed:22206000). Activates expression of CDKN1A and CDKN2A in
CC endothelial cells, acting as a regulator of vascular cell proliferation
CC (PubMed:17074759, PubMed:22206000). While it activates CDKN1A in a DNA-
CC dependent manner, it activates CDKN2A in a DNA-independent manner
CC (PubMed:22206000). Together with TCF15, regulates transcription in
CC heart endothelial cells to regulate fatty acid transport across heart
CC endothelial cells (By similarity). {ECO:0000250|UniProtKB:P32443,
CC ECO:0000250|UniProtKB:P39020, ECO:0000269|PubMed:17074759,
CC ECO:0000269|PubMed:20516212, ECO:0000269|PubMed:22206000}.
CC -!- SUBUNIT: Interacts with RNF10 (PubMed:16335786). Interacts with TCF15
CC (By similarity). {ECO:0000250|UniProtKB:P32443,
CC ECO:0000269|PubMed:16335786}.
CC -!- INTERACTION:
CC P50222; O43707: ACTN4; NbExp=3; IntAct=EBI-748397, EBI-351526;
CC P50222; P58397: ADAMTS12; NbExp=3; IntAct=EBI-748397, EBI-9028051;
CC P50222; Q99943: AGPAT1; NbExp=3; IntAct=EBI-748397, EBI-3893468;
CC P50222; O43865: AHCYL1; NbExp=3; IntAct=EBI-748397, EBI-2371423;
CC P50222; Q719I0: AHSA2P; NbExp=3; IntAct=EBI-748397, EBI-9361704;
CC P50222; Q92688: ANP32B; NbExp=3; IntAct=EBI-748397, EBI-762428;
CC P50222; Q6P4J0: ARD1A; NbExp=3; IntAct=EBI-748397, EBI-10252815;
CC P50222; Q14155: ARHGEF7; NbExp=3; IntAct=EBI-748397, EBI-717515;
CC P50222; A9UGY9: ATG5; NbExp=3; IntAct=EBI-748397, EBI-10175276;
CC P50222; Q5TBC7: BCL2L15; NbExp=3; IntAct=EBI-748397, EBI-10247136;
CC P50222; Q06187: BTK; NbExp=3; IntAct=EBI-748397, EBI-624835;
CC P50222; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-748397, EBI-8643161;
CC P50222; Q9H257: CARD9; NbExp=3; IntAct=EBI-748397, EBI-751319;
CC P50222; P31944: CASP14; NbExp=3; IntAct=EBI-748397, EBI-2510738;
CC P50222; Q8IW40: CCDC103; NbExp=3; IntAct=EBI-748397, EBI-10261970;
CC P50222; P24863: CCNC; NbExp=3; IntAct=EBI-748397, EBI-395261;
CC P50222; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-748397, EBI-10181988;
CC P50222; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-748397, EBI-741528;
CC P50222; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-748397, EBI-947551;
CC P50222; P07510-2: CHRNG; NbExp=3; IntAct=EBI-748397, EBI-11979451;
CC P50222; Q6FI81: CIAPIN1; NbExp=3; IntAct=EBI-748397, EBI-750511;
CC P50222; Q96Q77: CIB3; NbExp=3; IntAct=EBI-748397, EBI-10292696;
CC P50222; Q9UHC6: CNTNAP2; NbExp=3; IntAct=EBI-748397, EBI-310892;
CC P50222; O95741: CPNE6; NbExp=3; IntAct=EBI-748397, EBI-719005;
CC P50222; O95639: CPSF4; NbExp=3; IntAct=EBI-748397, EBI-725860;
CC P50222; Q9UGL9: CRCT1; NbExp=4; IntAct=EBI-748397, EBI-713677;
CC P50222; Q9Y534: CSDC2; NbExp=3; IntAct=EBI-748397, EBI-1763657;
CC P50222; P04141: CSF2; NbExp=6; IntAct=EBI-748397, EBI-1809826;
CC P50222; Q8WYA6: CTNNBL1; NbExp=3; IntAct=EBI-748397, EBI-748128;
CC P50222; Q9P0U4: CXXC1; NbExp=3; IntAct=EBI-748397, EBI-949911;
CC P50222; Q8WYQ5: DGCR8; NbExp=3; IntAct=EBI-748397, EBI-528411;
CC P50222; Q8NF50: DOCK8; NbExp=3; IntAct=EBI-748397, EBI-2548605;
CC P50222; Q96FJ2: DYNLL2; NbExp=3; IntAct=EBI-748397, EBI-742371;
CC P50222; Q8N7M0: DYNLT5; NbExp=3; IntAct=EBI-748397, EBI-10267606;
CC P50222; O60869: EDF1; NbExp=3; IntAct=EBI-748397, EBI-781301;
CC P50222; Q12805: EFEMP1; NbExp=3; IntAct=EBI-748397, EBI-536772;
CC P50222; O95967: EFEMP2; NbExp=3; IntAct=EBI-748397, EBI-743414;
CC P50222; P52797: EFNA3; NbExp=3; IntAct=EBI-748397, EBI-722730;
CC P50222; Q8N9N8: EIF1AD; NbExp=3; IntAct=EBI-748397, EBI-750700;
CC P50222; P63241: EIF5A; NbExp=3; IntAct=EBI-748397, EBI-373150;
CC P50222; P50402: EMD; NbExp=3; IntAct=EBI-748397, EBI-489887;
CC P50222; Q7L775: EPM2AIP1; NbExp=3; IntAct=EBI-748397, EBI-6255981;
CC P50222; P62508: ESRRG; NbExp=3; IntAct=EBI-748397, EBI-2834260;
CC P50222; Q8NE31: FAM13C; NbExp=3; IntAct=EBI-748397, EBI-751248;
CC P50222; Q9BU27: FAM3A; NbExp=3; IntAct=EBI-748397, EBI-10298603;
CC P50222; Q5TZK3: FAM74A6; NbExp=3; IntAct=EBI-748397, EBI-10247271;
CC P50222; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-748397, EBI-10244131;
CC P50222; Q9UBX5: FBLN5; NbExp=3; IntAct=EBI-748397, EBI-947897;
CC P50222; O75344: FKBP6; NbExp=3; IntAct=EBI-748397, EBI-744771;
CC P50222; Q6PIV2: FOXR1; NbExp=3; IntAct=EBI-748397, EBI-10253815;
CC P50222; Q9BTY2: FUCA2; NbExp=4; IntAct=EBI-748397, EBI-9050116;
CC P50222; Q495W5: FUT11; NbExp=3; IntAct=EBI-748397, EBI-2907712;
CC P50222; A0A158RFV5: GAGE1; NbExp=3; IntAct=EBI-748397, EBI-22578224;
CC P50222; Q8NEA9: GMCL2; NbExp=3; IntAct=EBI-748397, EBI-745707;
CC P50222; Q9P2T1: GMPR2; NbExp=3; IntAct=EBI-748397, EBI-2806548;
CC P50222; Q53Y01: GNG11; NbExp=3; IntAct=EBI-748397, EBI-10243023;
CC P50222; Q0D2H9: GOLGA8DP; NbExp=3; IntAct=EBI-748397, EBI-10181276;
CC P50222; Q08AF8: GOLGA8G; NbExp=3; IntAct=EBI-748397, EBI-10181260;
CC P50222; Q9NWQ4: GPATCH2L; NbExp=3; IntAct=EBI-748397, EBI-5666657;
CC P50222; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-748397, EBI-347538;
CC P50222; O14929: HAT1; NbExp=3; IntAct=EBI-748397, EBI-2339359;
CC P50222; O14929-2: HAT1; NbExp=3; IntAct=EBI-748397, EBI-10181798;
CC P50222; Q9H0R4: HDHD2; NbExp=3; IntAct=EBI-748397, EBI-10304657;
CC P50222; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-748397, EBI-5460660;
CC P50222; P14210: HGF; NbExp=3; IntAct=EBI-748397, EBI-1039104;
CC P50222; Q5SSJ5: HP1BP3; NbExp=3; IntAct=EBI-748397, EBI-2880687;
CC P50222; P28566: HTR1E; NbExp=3; IntAct=EBI-748397, EBI-1043151;
CC P50222; Q86VF2: IGFN1; NbExp=3; IntAct=EBI-748397, EBI-10259767;
CC P50222; P01583: IL1A; NbExp=3; IntAct=EBI-748397, EBI-1749782;
CC P50222; Q9UHH9: IP6K2; NbExp=3; IntAct=EBI-748397, EBI-747509;
CC P50222; O43736: ITM2A; NbExp=3; IntAct=EBI-748397, EBI-2431769;
CC P50222; Q92993: KAT5; NbExp=3; IntAct=EBI-748397, EBI-399080;
CC P50222; Q2M2Z5: KIZ; NbExp=3; IntAct=EBI-748397, EBI-2554344;
CC P50222; Q9NSK0: KLC4; NbExp=3; IntAct=EBI-748397, EBI-949319;
CC P50222; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-748397, EBI-6426443;
CC P50222; Q6KB66: KRT80; NbExp=3; IntAct=EBI-748397, EBI-3046635;
CC P50222; O43790: KRT86; NbExp=3; IntAct=EBI-748397, EBI-9996498;
CC P50222; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-748397, EBI-10217483;
CC P50222; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-748397, EBI-10172150;
CC P50222; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-748397, EBI-10171774;
CC P50222; P60411: KRTAP10-9; NbExp=4; IntAct=EBI-748397, EBI-10172052;
CC P50222; P59990: KRTAP12-1; NbExp=4; IntAct=EBI-748397, EBI-10210845;
CC P50222; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-748397, EBI-10176396;
CC P50222; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-748397, EBI-10302392;
CC P50222; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-748397, EBI-10172511;
CC P50222; Q9BYR0: KRTAP4-7; NbExp=3; IntAct=EBI-748397, EBI-10302547;
CC P50222; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-748397, EBI-10250562;
CC P50222; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-748397, EBI-3958099;
CC P50222; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-748397, EBI-1044640;
CC P50222; Q86UP2: KTN1; NbExp=3; IntAct=EBI-748397, EBI-359761;
CC P50222; A0A0C4DGV4: LAMTOR5; NbExp=3; IntAct=EBI-748397, EBI-10173304;
CC P50222; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-748397, EBI-10245913;
CC P50222; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-748397, EBI-10246607;
CC P50222; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-748397, EBI-10246358;
CC P50222; Q9Y333: LSM2; NbExp=3; IntAct=EBI-748397, EBI-347416;
CC P50222; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-748397, EBI-716006;
CC P50222; O60336: MAPKBP1; NbExp=3; IntAct=EBI-748397, EBI-947402;
CC P50222; Q6NSB6: MKRN3; NbExp=3; IntAct=EBI-748397, EBI-10195599;
CC P50222; Q6P2C6: MLLT6; NbExp=3; IntAct=EBI-748397, EBI-5773143;
CC P50222; P08254: MMP3; NbExp=3; IntAct=EBI-748397, EBI-6957351;
CC P50222; Q6PF18: MORN3; NbExp=3; IntAct=EBI-748397, EBI-9675802;
CC P50222; Q96HT8: MRFAP1L1; NbExp=3; IntAct=EBI-748397, EBI-748896;
CC P50222; Q96DH6: MSI2; NbExp=3; IntAct=EBI-748397, EBI-2462339;
CC P50222; A1L3X4: MT1DP; NbExp=3; IntAct=EBI-748397, EBI-10172129;
CC P50222; Q9H6H2: MUM1; NbExp=3; IntAct=EBI-748397, EBI-10307610;
CC P50222; P41227: NAA10; NbExp=3; IntAct=EBI-748397, EBI-747693;
CC P50222; Q8IZF0: NALCN; NbExp=3; IntAct=EBI-748397, EBI-7085333;
CC P50222; P61601: NCALD; NbExp=3; IntAct=EBI-748397, EBI-749635;
CC P50222; O43639: NCK2; NbExp=3; IntAct=EBI-748397, EBI-713635;
CC P50222; P20783: NTF3; NbExp=3; IntAct=EBI-748397, EBI-1025994;
CC P50222; Q96NG3: ODAD4; NbExp=3; IntAct=EBI-748397, EBI-1046387;
CC P50222; Q8WWZ8: OIT3; NbExp=3; IntAct=EBI-748397, EBI-10277776;
CC P50222; Q9UJX0: OSGIN1; NbExp=3; IntAct=EBI-748397, EBI-9057006;
CC P50222; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-748397, EBI-10181968;
CC P50222; Q9UNF0: PACSIN2; NbExp=3; IntAct=EBI-748397, EBI-742503;
CC P50222; Q7Z2X7: PAGE2; NbExp=3; IntAct=EBI-748397, EBI-10256818;
CC P50222; Q9HBI0: PARVG; NbExp=3; IntAct=EBI-748397, EBI-3921217;
CC P50222; Q92824: PCSK5; NbExp=3; IntAct=EBI-748397, EBI-751290;
CC P50222; Q96JS3: PGBD1; NbExp=6; IntAct=EBI-748397, EBI-10290053;
CC P50222; Q13526: PIN1; NbExp=3; IntAct=EBI-748397, EBI-714158;
CC P50222; Q549H9: PKIG; NbExp=3; IntAct=EBI-748397, EBI-10243311;
CC P50222; A1L4L9: POM121C; NbExp=3; IntAct=EBI-748397, EBI-10172978;
CC P50222; O43741: PRKAB2; NbExp=3; IntAct=EBI-748397, EBI-1053424;
CC P50222; A6NJB7: PRR19; NbExp=3; IntAct=EBI-748397, EBI-10174045;
CC P50222; P40306: PSMB10; NbExp=3; IntAct=EBI-748397, EBI-603329;
CC P50222; P62191: PSMC1; NbExp=3; IntAct=EBI-748397, EBI-357598;
CC P50222; Q53XL8: PSMC1; NbExp=3; IntAct=EBI-748397, EBI-10242995;
CC P50222; O00487: PSMD14; NbExp=3; IntAct=EBI-748397, EBI-722193;
CC P50222; P43115-12: PTGER3; NbExp=3; IntAct=EBI-748397, EBI-10234038;
CC P50222; P10826-2: RARB; NbExp=3; IntAct=EBI-748397, EBI-8583223;
CC P50222; Q96PM5: RCHY1; NbExp=3; IntAct=EBI-748397, EBI-947779;
CC P50222; Q6P9E2: RECK; NbExp=3; IntAct=EBI-748397, EBI-10253121;
CC P50222; Q9H4E5: RHOJ; NbExp=3; IntAct=EBI-748397, EBI-6285694;
CC P50222; Q9H871: RMND5A; NbExp=3; IntAct=EBI-748397, EBI-2797992;
CC P50222; P61313: RPL15; NbExp=3; IntAct=EBI-748397, EBI-443462;
CC P50222; Q06455-4: RUNX1T1; NbExp=3; IntAct=EBI-748397, EBI-10224192;
CC P50222; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-748397, EBI-748391;
CC P50222; Q01105: SET; NbExp=3; IntAct=EBI-748397, EBI-1053182;
CC P50222; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-748397, EBI-10313866;
CC P50222; O00241-2: SIRPB1; NbExp=3; IntAct=EBI-748397, EBI-10179231;
CC P50222; Q6P1K1: SLC48A1; NbExp=3; IntAct=EBI-748397, EBI-1222191;
CC P50222; P84022: SMAD3; NbExp=6; IntAct=EBI-748397, EBI-347161;
CC P50222; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-748397, EBI-455078;
CC P50222; P10451: SPP1; NbExp=3; IntAct=EBI-748397, EBI-723648;
CC P50222; O43609: SPRY1; NbExp=4; IntAct=EBI-748397, EBI-3866665;
CC P50222; O43597: SPRY2; NbExp=3; IntAct=EBI-748397, EBI-742487;
CC P50222; Q99909: SSX3; NbExp=3; IntAct=EBI-748397, EBI-10295431;
CC P50222; O75716: STK16; NbExp=3; IntAct=EBI-748397, EBI-749295;
CC P50222; O75558: STX11; NbExp=3; IntAct=EBI-748397, EBI-714135;
CC P50222; O14662: STX16; NbExp=3; IntAct=EBI-748397, EBI-2853548;
CC P50222; P61764: STXBP1; NbExp=3; IntAct=EBI-748397, EBI-960169;
CC P50222; Q9BSW7: SYT17; NbExp=3; IntAct=EBI-748397, EBI-745392;
CC P50222; Q5QJ74: TBCEL; NbExp=3; IntAct=EBI-748397, EBI-10244795;
CC P50222; Q15560: TCEA2; NbExp=3; IntAct=EBI-748397, EBI-710310;
CC P50222; A0A024R6G0: TCL6; NbExp=3; IntAct=EBI-748397, EBI-10173366;
CC P50222; P01137: TGFB1; NbExp=3; IntAct=EBI-748397, EBI-779636;
CC P50222; Q86XR7: TICAM2; NbExp=3; IntAct=EBI-748397, EBI-525927;
CC P50222; Q9NV29: TMEM100; NbExp=3; IntAct=EBI-748397, EBI-8644968;
CC P50222; Q12888: TP53BP1; NbExp=3; IntAct=EBI-748397, EBI-396540;
CC P50222; Q9Y4K3: TRAF6; NbExp=3; IntAct=EBI-748397, EBI-359276;
CC P50222; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-748397, EBI-725997;
CC P50222; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-748397, EBI-5235829;
CC P50222; Q5VTQ0-4: TTC39B; NbExp=3; IntAct=EBI-748397, EBI-10247626;
CC P50222; Q8N5M4: TTC9C; NbExp=3; IntAct=EBI-748397, EBI-2851213;
CC P50222; P40222: TXLNA; NbExp=3; IntAct=EBI-748397, EBI-359793;
CC P50222; P11441: UBL4A; NbExp=3; IntAct=EBI-748397, EBI-356983;
CC P50222; Q8N7F7: UBL4B; NbExp=3; IntAct=EBI-748397, EBI-10267507;
CC P50222; Q9H3U1: UNC45A; NbExp=3; IntAct=EBI-748397, EBI-1048763;
CC P50222; Q9NZ43: USE1; NbExp=3; IntAct=EBI-748397, EBI-742842;
CC P50222; P11473: VDR; NbExp=3; IntAct=EBI-748397, EBI-286357;
CC P50222; Q8NEX5: WFDC9; NbExp=3; IntAct=EBI-748397, EBI-10270812;
CC P50222; O43543: XRCC2; NbExp=3; IntAct=EBI-748397, EBI-3918457;
CC P50222; O75132: ZBED4; NbExp=3; IntAct=EBI-748397, EBI-2860059;
CC P50222; Q96NC0: ZMAT2; NbExp=3; IntAct=EBI-748397, EBI-2682299;
CC P50222; Q15973: ZNF124; NbExp=3; IntAct=EBI-748397, EBI-2555767;
CC P50222; Q86UD4: ZNF329; NbExp=3; IntAct=EBI-748397, EBI-7233259;
CC P50222; Q494X3: ZNF404; NbExp=3; IntAct=EBI-748397, EBI-10241626;
CC P50222; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-748397, EBI-740727;
CC P50222; Q6P088: ZNF483; NbExp=3; IntAct=EBI-748397, EBI-10196963;
CC P50222; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-748397, EBI-10273713;
CC P50222; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-748397, EBI-10172590;
CC P50222; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-748397, EBI-6427977;
CC P50222; Q8IW36: ZNF695; NbExp=3; IntAct=EBI-748397, EBI-10261951;
CC P50222; Q6ZVW3; NbExp=3; IntAct=EBI-748397, EBI-10255586;
CC P50222; Q7Z783; NbExp=3; IntAct=EBI-748397, EBI-9088990;
CC P50222; Q9NWJ2; NbExp=3; IntAct=EBI-748397, EBI-10315029;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19266028,
CC ECO:0000269|PubMed:22206000}. Nucleus speckle
CC {ECO:0000269|PubMed:19266028}.
CC -!- INDUCTION: Expression is repressed by ZEB2.
CC {ECO:0000269|PubMed:20516212}.
CC -!- DOMAIN: The polyhistidine repeat may act as a targeting signal to
CC nuclear speckles. {ECO:0000269|PubMed:19266028}.
CC -!- POLYMORPHISM: The poly-His region of MEOX2 is polymorphic and the
CC number of His varies in the population. {ECO:0000269|PubMed:19760604}.
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DR EMBL; X82629; CAA57949.1; -; mRNA.
DR EMBL; L36328; AAA58497.1; -; mRNA.
DR EMBL; AK313386; BAG36184.1; -; mRNA.
DR EMBL; AC005550; AAC33152.1; -; Genomic_DNA.
DR EMBL; AC004452; AAC06184.1; -; Genomic_DNA.
DR EMBL; CH236948; EAL24289.1; -; Genomic_DNA.
DR EMBL; BC017021; AAH17021.1; -; mRNA.
DR CCDS; CCDS34605.1; -.
DR PIR; A55641; A55641.
DR PIR; A56837; A56837.
DR RefSeq; NP_005915.2; NM_005924.4.
DR AlphaFoldDB; P50222; -.
DR SMR; P50222; -.
DR BioGRID; 110386; 747.
DR IntAct; P50222; 208.
DR MINT; P50222; -.
DR STRING; 9606.ENSP00000262041; -.
DR MoonDB; P50222; Predicted.
DR iPTMnet; P50222; -.
DR PhosphoSitePlus; P50222; -.
DR BioMuta; MEOX2; -.
DR DMDM; 93141286; -.
DR MassIVE; P50222; -.
DR PaxDb; P50222; -.
DR PeptideAtlas; P50222; -.
DR PRIDE; P50222; -.
DR ProteomicsDB; 56206; -.
DR Antibodypedia; 11796; 417 antibodies from 35 providers.
DR DNASU; 4223; -.
DR Ensembl; ENST00000262041.6; ENSP00000262041.5; ENSG00000106511.6.
DR GeneID; 4223; -.
DR KEGG; hsa:4223; -.
DR MANE-Select; ENST00000262041.6; ENSP00000262041.5; NM_005924.5; NP_005915.2.
DR UCSC; uc003stc.4; human.
DR CTD; 4223; -.
DR DisGeNET; 4223; -.
DR GeneCards; MEOX2; -.
DR HGNC; HGNC:7014; MEOX2.
DR HPA; ENSG00000106511; Tissue enhanced (adipose tissue, placenta).
DR MIM; 600535; gene.
DR neXtProt; NX_P50222; -.
DR OpenTargets; ENSG00000106511; -.
DR PharmGKB; PA30748; -.
DR VEuPathDB; HostDB:ENSG00000106511; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000154018; -.
DR HOGENOM; CLU_081326_0_0_1; -.
DR InParanoid; P50222; -.
DR OMA; QHHASWH; -.
DR OrthoDB; 1522857at2759; -.
DR PhylomeDB; P50222; -.
DR TreeFam; TF351603; -.
DR PathwayCommons; P50222; -.
DR SignaLink; P50222; -.
DR SIGNOR; P50222; -.
DR BioGRID-ORCS; 4223; 8 hits in 1100 CRISPR screens.
DR ChiTaRS; MEOX2; human.
DR GeneWiki; MEOX2; -.
DR GenomeRNAi; 4223; -.
DR Pharos; P50222; Tbio.
DR PRO; PR:P50222; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P50222; protein.
DR Bgee; ENSG00000106511; Expressed in calcaneal tendon and 146 other tissues.
DR Genevisible; P50222; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0060173; P:limb development; IEA:Ensembl.
DR GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IGI:BHF-UCL.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR GO; GO:0061053; P:somite development; IBA:GO_Central.
DR GO; GO:0001757; P:somite specification; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR042634; MOX-1/MOX-2.
DR PANTHER; PTHR24328; PTHR24328; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..304
FT /note="Homeobox protein MOX-2"
FT /id="PRO_0000049197"
FT DNA_BIND 187..246
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 63..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..83
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 79..80
FT /note="Missing"
FT /evidence="ECO:0000269|PubMed:7713505"
FT /id="VAR_026040"
FT VARIANT 80
FT /note="Missing"
FT /evidence="ECO:0000269|PubMed:12690205,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:7607679"
FT /id="VAR_026041"
FT VARIANT 287
FT /note="I -> L (in dbSNP:rs2237493)"
FT /id="VAR_049585"
FT MUTAGEN 236
FT /note="Q->E: Abolishes DNA-binding. Does not affect ability
FT to activate expression of CDKN2A."
FT /evidence="ECO:0000269|PubMed:22206000"
FT CONFLICT 58
FT /note="G -> D (in Ref. 2; AAA58497)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 304 AA; 33594 MW; 0C008479D6995389 CRC64;
MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII AGYPNEEGMF
ASQHHRGHHH HHHHHHHHHH QQQQHQALQT NWHLPQMSSP PSAARHSLCL QPDSGGPPEL
GSSPPVLCSN SSSLGSSTPT GAACAPGDYG RQALSPAEAE KRSGGKRKSD SSDSQEGNYK
SEVNSKPRKE RTAFTKEQIR ELEAEFAHHN YLTRLRRYEI AVNLDLTERQ VKVWFQNRRM
KWKRVKGGQQ GAAAREKELV NVKKGTLLPS ELSGIGAATL QQTGDSIANE DSHDSDHSSE
HAHL
