ID   MEOX2_XENLA             Reviewed;         298 AA.
AC   P39021;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Homeobox protein MOX-2 {ECO:0000303|PubMed:7909944};
GN   Name=meox2 {ECO:0000250|UniProtKB:P50222};
GN   Synonyms=mox2 {ECO:0000303|PubMed:7909944};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7909944; DOI=10.1093/nar/21.21.4982;
RA   Candia A.F., Kovalik J.-P., Wright C.V.E.;
RT   "Amino acid sequence of Mox-2 and comparison to its Xenopus and rat
RT   homologs.";
RL   Nucleic Acids Res. 21:4982-4982(1993).
CC   -!- FUNCTION: Mesodermal transcription factor that plays a key role in
CC       somitogenesis and somitogenesis and limb muscle differentiation.
CC       Required during limb development for normal appendicular muscle
CC       formation and for the normal regulation of myogenic genes. Also acts as
CC       a negative regulator of angiogenesis. {ECO:0000250|UniProtKB:P32443}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P50222}. Nucleus
CC       speckle {ECO:0000250|UniProtKB:P50222}.
CC   -!- DOMAIN: The polyhistidine repeat may act as a targeting signal to
CC       nuclear speckles. {ECO:0000250|UniProtKB:P50222}.
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DR   EMBL; L20432; AAB00146.1; -; mRNA.
DR   PIR; S41469; S41469.
DR   RefSeq; NP_001165453.1; NM_001171982.1.
DR   AlphaFoldDB; P39021; -.
DR   SMR; P39021; -.
DR   GeneID; 100337513; -.
DR   KEGG; xla:100337513; -.
DR   CTD; 100337513; -.
DR   Xenbase; XB-GENE-6464370; meox2.L.
DR   OrthoDB; 1522857at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 100337513; Expressed in muscle tissue and 10 other tissues.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR042634; MOX-1/MOX-2.
DR   PANTHER; PTHR24328; PTHR24328; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..298
FT                   /note="Homeobox protein MOX-2"
FT                   /id="PRO_0000049200"
FT   DNA_BIND        181..240
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          57..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          143..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          277..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..79
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..122
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..169
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   298 AA;  33245 MW;  154123DDED90824F CRC64;
     MEHTLFGCLR SPHATSQGLH PFAQSSLALH GRSDHMSYPD LSSSSSSCIL TGYPNEESMF
     GSQHHRGHHH HHHHHHQQQQ HQTLQSNWHI PQMSSPPAST RHSLCLQQDS GPPDLSGSPS
     ILCSNTSSLG TNNSTGAACV TGDYGRQSLS PAEAEKRTGK RKSDSSDSQE GSYKSDVNSK
     PRKERTAFTK EQIRELEAEF AHHNYLTRLR RYEIAVNLDL TERQVKVWFQ NRRMKWKRVK
     GGQQGAAARE KELVNVKKGT LLPSELSGIR SNSLQHTADS LTNDDSHDSS QSSEHAHL