ARI5B_DANRE
ID ARI5B_DANRE Reviewed; 1044 AA.
AC E7F888;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=AT-rich interactive domain-containing protein 5B;
DE Short=ARID domain-containing protein 5B;
GN Name=arid5b;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: Transcription coactivator that binds to the 5'-AATA[CT]-3'
CC core sequence and plays a key role in adipogenesis and liver
CC development. Required for adipogenesis: regulates triglyceride
CC metabolism in adipocytes by regulating expression of adipogenic genes
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}.
CC -!- DOMAIN: The ARID domain mediates the interaction with DNA.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ARID5B family. {ECO:0000305}.
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DR EMBL; CABZ01071109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071112; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01071135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR354434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E7F888; -.
DR SMR; E7F888; -.
DR STRING; 7955.ENSDARP00000054091; -.
DR PaxDb; E7F888; -.
DR PRIDE; E7F888; -.
DR ZFIN; ZDB-GENE-121214-272; arid5b.
DR eggNOG; KOG2744; Eukaryota.
DR HOGENOM; CLU_007985_0_0_1; -.
DR InParanoid; E7F888; -.
DR OMA; YRQTEHH; -.
DR PhylomeDB; E7F888; -.
DR TreeFam; TF324725; -.
DR Reactome; R-DRE-3214842; HDMs demethylate histones.
DR PRO; PR:E7F888; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR GO; GO:0060612; P:adipose tissue development; ISS:UniProtKB.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.150.60; -; 1.
DR InterPro; IPR030408; ARID5B.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR PANTHER; PTHR13964:SF37; PTHR13964:SF37; 2.
DR Pfam; PF01388; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SUPFAM; SSF46774; SSF46774; 1.
DR PROSITE; PS51011; ARID; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1044
FT /note="AT-rich interactive domain-containing protein 5B"
FT /id="PRO_0000410901"
FT DOMAIN 212..304
FT /note="ARID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00355"
FT REGION 143..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..632
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1044 AA; 115806 MW; 2216D3938D253D49 CRC64;
MVSDLRSWKK GLQAVPLKPG VLKELGKNGQ REALHKYRES TLNSGLNFKD VLKEKAELGE
DADDKKVLVL SYPQYCRYRS IIARLRERPS SLLTDHVVLA LGGIASLTNS TQILYCRDTF
EHPTLVENES VCDEFAPNLK GRPRKKKLSI SQRRDSQSGG ARESNGVEGK TLVKMRADSK
SGVSKPRNPS TGSCKRVQSE NKPKGDGGDE CRTDEQAFLV ALYKYMKERK TPIERIPYLG
FKQINLWTMF QAAQKLGGYE VITARRQWKN VYDELGGNPG STSAATCTRR HYERLILPYE
RFTKGEEDKP LPPAKPRKQE GSVQESIIKA KMMPIKRPKD EQKTPRGDKD ASAKVLELGM
EDMEELQEKQ NSQQLQAPTQ TDRDPNSPLT EDDEGVLVIK DEDQPVLHNA YEHANGGLLP
SLPQDGAQLK SEDCDAFPVA AVPLHHGHPL PNSHTSDQWK HGILEYKVPP SALANVEQSR
PKEGQNQVVM VLPTLQQKPV TSPEIPPERV EPLKKEESCF NFNPLLYPRG NPGIMSPLAK
KKMLSQVSGT GLLNNYPYGP PPPLVSRRLS SSGTEVSSAG QSSSQVSSSV ETSIVIKRPS
VIQHAQSFKS RGSEDRRSST EGSQKDGCSE GEPVHHSQTL IREPYLKRVD PHSSMEKSAE
MPRPGQAPSF LSEFYSSPHL HNLCRQTEHH LSKEQISKYL SRDVYTRDSE TAQGFPPSQH
PDNVGLNFSA RLSQKEKGPP PERVTEEQPT DLSLPKSSPL KLPLSTSTLG GIPHAAIQQD
IKNSPHFQAG NSQSSSVDYH PRACRVPPMT VSASKKVTES HSKVLEKTPN SRGEESMGFK
IDEMSRPILS TKSSPQNICT ARPLKRNIED LENGPTEKKI RAVTPLHCST QRDLPGKPRT
PEADSESVKP AEPAVHINSY TSEGHKIPLH SHLFQGLYPG TFVSQVQDMC ESLGSHVTPS
YSHPLQYLKN QAVLSPLMPP FAIHSLMMQR QFLAANPAHM YRHQVGTSYG DILHPGLYPM
SALHPQPAFS PPQLSSVHPS TKLS
