ARID1_CAEEL
ID ARID1_CAEEL Reviewed; 1648 AA.
AC A0A0K3AXH1; A0A0K3ARP6; A0A0K3AS59; A0A0K3AS65; A0A0K3AUK2; A0A0K3AV74;
AC A0A0K3AVY5; A0A0K3AXH5; G4SB35; Q95Y31;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 11-NOV-2015, sequence version 1.
DT 03-AUG-2022, entry version 43.
DE RecName: Full=AT-rich interactive domain-containing protein arid-1 {ECO:0000312|WormBase:Y108G3AL.7b};
GN Name=arid-1 {ECO:0000312|WormBase:Y108G3AL.7b};
GN ORFNames=Y108G3AL.7 {ECO:0000312|WormBase:Y108G3AL.7b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION.
RX PubMed=30287474; DOI=10.1534/genetics.118.301450;
RA Tillman E.J., Richardson C.E., Cattie D.J., Reddy K.C., Lehrbach N.J.,
RA Droste R., Ruvkun G., Kim D.H.;
RT "Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead
RT Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.";
RL Genetics 210:1329-1337(2018).
CC -!- FUNCTION: DNA-binding protein which modulates activity of several
CC transcription factors (By similarity). Plays a role in the modulation
CC of endoplasmic reticulum (ER) homeostasis during chemical and pathogen
CC stress, including exposure to the Gram-negative bacterium P.aeruginosa
CC (PubMed:30287474). {ECO:0000250|UniProtKB:F8VPQ2,
CC ECO:0000269|PubMed:30287474}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355,
CC ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=9;
CC Name=b {ECO:0000312|WormBase:Y108G3AL.7b};
CC IsoId=A0A0K3AXH1-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:Y108G3AL.7a};
CC IsoId=A0A0K3AXH1-2; Sequence=VSP_061281;
CC Name=c {ECO:0000312|WormBase:Y108G3AL.7c};
CC IsoId=A0A0K3AXH1-3; Sequence=VSP_061280;
CC Name=d {ECO:0000312|WormBase:Y108G3AL.7d};
CC IsoId=A0A0K3AXH1-4; Sequence=VSP_061280, VSP_061281;
CC Name=e {ECO:0000312|WormBase:Y108G3AL.7e};
CC IsoId=A0A0K3AXH1-5; Sequence=VSP_061279;
CC Name=f {ECO:0000312|WormBase:Y108G3AL.7f};
CC IsoId=A0A0K3AXH1-6; Sequence=VSP_061279, VSP_061281;
CC Name=g {ECO:0000312|WormBase:Y108G3AL.7g};
CC IsoId=A0A0K3AXH1-7; Sequence=VSP_061278;
CC Name=h {ECO:0000312|WormBase:Y108G3AL.7h};
CC IsoId=A0A0K3AXH1-8; Sequence=VSP_061278, VSP_061281;
CC Name=i {ECO:0000312|WormBase:Y108G3AL.7i};
CC IsoId=A0A0K3AXH1-9; Sequence=VSP_061277;
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DR EMBL; BX284605; CCD74339.1; -; Genomic_DNA.
DR EMBL; BX284605; CTQ86703.1; -; Genomic_DNA.
DR EMBL; BX284605; CTQ86704.1; -; Genomic_DNA.
DR EMBL; BX284605; CTQ86705.1; -; Genomic_DNA.
DR EMBL; BX284605; CTQ86706.1; -; Genomic_DNA.
DR EMBL; BX284605; CTQ86707.1; -; Genomic_DNA.
DR EMBL; BX284605; CTQ86708.1; -; Genomic_DNA.
DR EMBL; BX284605; CTQ86709.1; -; Genomic_DNA.
DR EMBL; BX284605; CTQ86917.1; -; Genomic_DNA.
DR RefSeq; NP_001300004.1; NM_001313075.1.
DR AlphaFoldDB; A0A0K3AXH1; -.
DR SMR; A0A0K3AXH1; -.
DR STRING; 6239.Y108G3AL.7; -.
DR EPD; A0A0K3AXH1; -.
DR EnsemblMetazoa; Y108G3AL.7a.1; Y108G3AL.7a.1; WBGene00044689. [A0A0K3AXH1-2]
DR EnsemblMetazoa; Y108G3AL.7b.1; Y108G3AL.7b.1; WBGene00044689. [A0A0K3AXH1-1]
DR EnsemblMetazoa; Y108G3AL.7c.1; Y108G3AL.7c.1; WBGene00044689. [A0A0K3AXH1-3]
DR EnsemblMetazoa; Y108G3AL.7d.1; Y108G3AL.7d.1; WBGene00044689. [A0A0K3AXH1-4]
DR EnsemblMetazoa; Y108G3AL.7e.1; Y108G3AL.7e.1; WBGene00044689. [A0A0K3AXH1-5]
DR EnsemblMetazoa; Y108G3AL.7f.1; Y108G3AL.7f.1; WBGene00044689. [A0A0K3AXH1-6]
DR EnsemblMetazoa; Y108G3AL.7g.1; Y108G3AL.7g.1; WBGene00044689. [A0A0K3AXH1-7]
DR EnsemblMetazoa; Y108G3AL.7h.1; Y108G3AL.7h.1; WBGene00044689. [A0A0K3AXH1-8]
DR EnsemblMetazoa; Y108G3AL.7i.1; Y108G3AL.7i.1; WBGene00044689. [A0A0K3AXH1-9]
DR GeneID; 4363100; -.
DR KEGG; cel:CELE_Y108G3AL.7; -.
DR CTD; 4363100; -.
DR WormBase; Y108G3AL.7a; CE45961; WBGene00044689; arid-1.
DR WormBase; Y108G3AL.7b; CE50771; WBGene00044689; arid-1.
DR WormBase; Y108G3AL.7c; CE50724; WBGene00044689; arid-1.
DR WormBase; Y108G3AL.7d; CE50859; WBGene00044689; arid-1.
DR WormBase; Y108G3AL.7e; CE50811; WBGene00044689; arid-1.
DR WormBase; Y108G3AL.7f; CE50718; WBGene00044689; arid-1.
DR WormBase; Y108G3AL.7g; CE50883; WBGene00044689; arid-1.
DR WormBase; Y108G3AL.7h; CE50807; WBGene00044689; arid-1.
DR WormBase; Y108G3AL.7i; CE35266; WBGene00044689; arid-1.
DR eggNOG; KOG2744; Eukaryota.
DR GeneTree; ENSGT00940000169343; -.
DR HOGENOM; CLU_237944_0_0_1; -.
DR OMA; TIFADHT; -.
DR OrthoDB; 1624495at2759; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00044689; Expressed in embryo and 3 other tissues.
DR ExpressionAtlas; A0A0K3AXH1; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0017053; C:transcription repressor complex; ISS:WormBase.
DR GO; GO:0003677; F:DNA binding; ISS:WormBase.
DR GO; GO:0098542; P:defense response to other organism; IGI:UniProtKB.
DR GO; GO:0036503; P:ERAD pathway; IMP:UniProtKB.
DR GO; GO:0010498; P:proteasomal protein catabolic process; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:WormBase.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IGI:UniProtKB.
DR Gene3D; 1.10.150.60; -; 1.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR Pfam; PF01388; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SUPFAM; SSF46774; SSF46774; 1.
DR PROSITE; PS51011; ARID; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1648
FT /note="AT-rich interactive domain-containing protein arid-
FT 1"
FT /id="PRO_0000454296"
FT DOMAIN 655..745
FT /note="ARID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00355"
FT REGION 150..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1095..1563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1628..1648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..193
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..249
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..820
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..890
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1155
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1164..1184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1211
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1214..1255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1283..1302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1333..1359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1390..1404
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1448..1475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1508..1530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1531..1552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1632..1648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..1534
FT /note="Missing (in isoform i)"
FT /evidence="ECO:0000305"
FT /id="VSP_061277"
FT VAR_SEQ 1..1238
FT /note="Missing (in isoform g and isoform h)"
FT /evidence="ECO:0000305"
FT /id="VSP_061278"
FT VAR_SEQ 1..663
FT /note="Missing (in isoform e and isoform f)"
FT /evidence="ECO:0000305"
FT /id="VSP_061279"
FT VAR_SEQ 1..47
FT /note="Missing (in isoform c and isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_061280"
FT VAR_SEQ 1374..1376
FT /note="Missing (in isoform a, isoform d, isoform f and
FT isoform h)"
FT /evidence="ECO:0000305"
FT /id="VSP_061281"
SQ SEQUENCE 1648 AA; 185512 MW; 336E3E87250BCF76 CRC64;
MSDDPAFLAL GTEVSAKFKG AYCEAKIQKV DRSLKVKVSL KESPFGQMIV QDNDLPNAKF
EINELTDVVF QRKFIRCQIQ SIKDQSKYHV VFNDGDEKEL RRTQLVLKGG KHFAADGNLD
SMPLTNPESF STPVIRGAAK RGAQKIRNAI SEASGSRGGA VLLHNDDDEN DEEDQEDGEN
EEDADDDDDD TEEQQQPRER RRAAAISAIG VLKKAIEDTQ SEESSADSSE ERERARSRRK
RKDEASSAVT SDEEDQEDLA TTDSENPVIN GASSAAALSK TLQRKLEKQA MKREKQRLKE
EEREEKLRLK EENREKKRRE KARIMELKRL EKVYRTSNAR IQENHEKSMT QIISHRSVRY
FARFSDLKHR RKKKKLYLHE HRQKVNSRIR NVKLYFAWRF VAHKARLSYF ARYALQWWRT
SEDQAYSLIR TEKLLRSQRR RDWVGSWLEG LEREKIRFVV IHESYTQARR ILKYIERGTE
KRTFAERCDI EYEDIESSTV SSHFRDQEWF PAVLFPQVFS DENGSEGRQR IVRHMGNGQL
VQVWEDDLVP FDWLPEYSFA DVTAMTEKKP VEMRRKFKLA WRFATDYAQN RLDARSIRSI
LEWKFIRPSS RRLKITPIPV QAPSPNRCGE DHDDLVSTPN ESDYDSDATI KNVDAETKDL
FVAMLVQFHD AHNSVIDTNP TIQGHEVDLY YLYELAKKTG GPKKVYAANL WSDYAKKLVP
AATDAEEELK TIFKNFLESY LAINTKLSWP MESLQPRTER KVVLPGQYSE SRKKRTQAIM
SQVQTPPTAP GSSKKGRVGS GGTRGRKRKV SSESVQLKKR NRKSSSRATT ASPGPSEDRF
SFQRPQDSDD VTDVPDDMTD HEDLLPEAAT RKKYERKSQT PGRRSLSSRR DDTTPVSSMA
AAPPKKGRPR KNTTVTTPVL SVPKSEGRGP RKEDTTTKFV RANVLSHILS GQKLRAFYGD
EWFRANAIED ATDCTDEIMD IMLAHQDFFT PDTPRLSPSA IQDLDKVLKK IRAKTHYTGW
NQRYDEFMKL EKLMVTVEDQ MIARGRFRHL PRGRELKAET LALVEKHFRA DDEDDGVPKT
LAFYLKIAQE ALSLSEKRAV ADDDESSDSD TDFEQKPDTS AAAAVNGGKS ESEEEEEEKT
VVMGGDEEAE EEVKSEDVLV ESVDQESPPT TSQGTTTPET AATGGLESES DEPEYPPVPE
ELVPPPPVLL ENFPSTDRFS SGGSSNYPTL SRQGSINSMA SPMFSPNSDL SLSGPLTLPR
SGPLTMANIR QSPTPDEVVG SLRKRLSQTS ESSESSELPP PPSAASKSKR IRRASERSID
SASEHHRMMR SPRILTTQHS SGALIFDIST TQPTDTSGPI EALSVRKPGR RKTVFAASPT
LLTSGPLTLS SSAPPPPPAS PAPPQHAQKT LGRPRKTPST SSRKPEEEDE AEQIPTTVVG
VTEEASVADS SAKEDLTSED GSATPQDEKD DSESTTTTDT ITPKSIRGGK RRRGGGRFGG
SYPVKPAKPG RKPKDPHAEE GADEKDPEDQ TPTTMTTSTP TRADSFQTQK NRMAKLMEGK
PHDYSFLDLP DFDKIIEEAP KEDINILMEE RTYELREIFA QCKADLSALE KRYRQQNEAK
RKAEFAAKTA SSAAAAQASS STCSTPRP
