ID   MEPA_STAHJ              Reviewed;         452 AA.
AC   Q4L8N9; Q4L8P0;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 2.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Multidrug export protein MepA;
GN   Name=mepA; OrderedLocusNames=SH0676/SH0677;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Multidrug resistance efflux protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. MepA subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE03985.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAE03986.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP006716; BAE03985.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP006716; BAE03986.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q4L8N9; -.
DR   SMR; Q4L8N9; -.
DR   STRING; 279808.SH0677; -.
DR   EnsemblBacteria; BAE03985; BAE03985; SH0676.
DR   EnsemblBacteria; BAE03986; BAE03986; SH0677.
DR   KEGG; sha:SH0676; -.
DR   KEGG; sha:SH0677; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_2588003_0_0_9; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd13143; MATE_MepA_like; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR045070; MATE_MepA-like.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..452
FT                   /note="Multidrug export protein MepA"
FT                   /id="PRO_0000290236"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        351..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        414..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   452 AA;  49223 MW;  6A9F228375DAA7E2 CRC64;
     MKDEQLFYFE ESSIFKAMMH FSLPMMIGSL LSVIYGILNI YFIGFLDNSH MISAISLTLP
     IFAVLMAFGN LFGVGGGTYI SRLLGAKDYI KSHYVSSFSI YSSLVLGLII AVITLPFTDQ
     IASILCASGE TLNYTSDYLK IEFLSTPFVI LFFVLEQFAR AIGKPIISMI GMLSSVGINI
     ILDPILIFGL HLDVVGAALG TAISNAIAGL FFIIYFSRKN ETLSFNVKHA KPTKAMMQEI
     FKIGIPAFLM VVLMGVTGLV VNLFLATYGN YAIASYGISF RLVQFPELII MGLSEGVVPL
     IAYNFVSNKT RMKDTIKVVI VSIAVIFAVC MTVVLVAGHS IVQLFSTDPQ IVVLATFILK
     VTMTSLLLNG IGFLFTGMLQ ATGQGRGATI MAIAQGTVII PVLFVLNSLF GLTGVIWSLL
     IAETVCAFLA MFIVYSLRNR LTVDKASLIE VE