ID   MEPA_STAS1              Reviewed;         451 AA.
AC   Q49VC5;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Multidrug export protein MepA;
GN   Name=mepA; OrderedLocusNames=SSP2140;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Multidrug resistance efflux protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. MepA subfamily. {ECO:0000305}.
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DR   EMBL; AP008934; BAE19285.1; -; Genomic_DNA.
DR   RefSeq; WP_011303776.1; NZ_MTGA01000039.1.
DR   AlphaFoldDB; Q49VC5; -.
DR   SMR; Q49VC5; -.
DR   STRING; 342451.SSP2140; -.
DR   DNASU; 3616348; -.
DR   EnsemblBacteria; BAE19285; BAE19285; SSP2140.
DR   KEGG; ssp:SSP2140; -.
DR   PATRIC; fig|342451.11.peg.2131; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_0_1_9; -.
DR   OMA; MDGIWLA; -.
DR   OrthoDB; 216729at2; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd13143; MATE_MepA_like; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR045070; MATE_MepA-like.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..451
FT                   /note="Multidrug export protein MepA"
FT                   /id="PRO_0000290237"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        397..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   451 AA;  48952 MW;  D859F1342CB2208D CRC64;
     MKDEQLYYFE KSSVFKGMMH FSVPMMIGSL LSVIYGILNI YFIGFLGDSH MISAISLTLP
     IFAVLMGLGN LFGIGGGTYI SRLLGAKDYV KTKFVSSFSI YGGLILGVIV ILMTIFATEQ
     IAHLLGARGE TLGFTSAYLK VMFLSAPFVI LFFILEQFAR SIGAPIISMI GMLASVVLNI
     ILDTILIFGF DLNVVGAALG TAISNVVASL FFIIYFLRKS DIITMSLSYV RPTKEILVEI
     FKVGFPAFLM SILMGVTGLV LNLFLAGYGN FAIASYGISF RLVQFPELII MGLCEGVVPL
     IAYNFMSDKA RMKNIIKVVI MTIVVIFAVC MVIVFTTGHQ LIGIFSNDAA IVGMATFMLK
     VTMTSLLLNG IGFLFTGMLQ ATGQGRGATI MAILQGVVII PVLFVMNGLF GLTGIVWSLL
     IAETICALAA MLIVYLLRDR LTVDKAELLE G