ID   MEPRM_MYCTU             Reviewed;         548 AA.
AC   O05318; F2GFX1; I6X0P9; Q7D8L2;
DT   05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Multidrug efflux system permease protein Rv1217c {ECO:0000305};
GN   OrderedLocusNames=Rv1217c {ECO:0000312|EMBL:CCP43973.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   SUBUNIT.
RX   PubMed=10978546; DOI=10.1111/j.1574-6976.2000.tb00550.x;
RA   Braibant M., Gilot P., Content J.;
RT   "The ATP binding cassette (ABC) transport systems of Mycobacterium
RT   tuberculosis.";
RL   FEMS Microbiol. Rev. 24:449-467(2000).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [4]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=23143285; DOI=10.1007/s00284-012-0215-3;
RA   Wang K., Pei H., Huang B., Zhu X., Zhang J., Zhou B., Zhu L., Zhang Y.,
RA   Zhou F.F.;
RT   "The expression of ABC efflux pump, Rv1217c-Rv1218c, and its association
RT   with multidrug resistance of Mycobacterium tuberculosis in China.";
RL   Curr. Microbiol. 66:222-226(2013).
RN   [5]
RP   INDUCTION.
RC   STRAIN=H37Rv;
RX   PubMed=24424575; DOI=10.1002/pro.2424;
RA   Kumar N., Radhakrishnan A., Wright C.C., Chou T.H., Lei H.T., Bolla J.R.,
RA   Tringides M.L., Rajashankar K.R., Su C.C., Purdy G.E., Yu E.W.;
RT   "Crystal structure of the transcriptional regulator Rv1219c of
RT   Mycobacterium tuberculosis.";
RL   Protein Sci. 23:423-432(2014).
CC   -!- FUNCTION: Probably part of the ABC transporter complex Rv1217c-Rv1218c
CC       involved in the resistance to a wide range of structurally unrelated
CC       drugs (PubMed:23143285). Probably responsible for the translocation of
CC       the substrate across the membrane (Probable).
CC       {ECO:0000269|PubMed:23143285, ECO:0000305}.
CC   -!- SUBUNIT: The complex is probably composed of two ATP-binding proteins
CC       (Rv1218c) and a transmembrane protein (Rv1217c).
CC       {ECO:0000305|PubMed:10978546}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- INDUCTION: Transcriptionally regulated by RaaS (Rv1219c)
CC       (PubMed:24424575). Expression increases in multidrug-resistant clinical
CC       strains (MDR-TB) compared to drug-susceptible strains
CC       (PubMed:23143285). {ECO:0000269|PubMed:23143285,
CC       ECO:0000269|PubMed:24424575}.
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DR   EMBL; AL123456; CCP43973.1; -; Genomic_DNA.
DR   RefSeq; NP_215733.1; NC_000962.3.
DR   RefSeq; WP_003898775.1; NZ_NVQJ01000039.1.
DR   AlphaFoldDB; O05318; -.
DR   STRING; 83332.Rv1217c; -.
DR   PaxDb; O05318; -.
DR   PRIDE; O05318; -.
DR   DNASU; 888401; -.
DR   GeneID; 888401; -.
DR   KEGG; mtu:Rv1217c; -.
DR   PATRIC; fig|83332.111.peg.1360; -.
DR   TubercuList; Rv1217c; -.
DR   eggNOG; COG3559; Bacteria.
DR   OMA; GDRWWVL; -.
DR   PhylomeDB; O05318; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic resistance; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..548
FT                   /note="Multidrug efflux system permease protein Rv1217c"
FT                   /id="PRO_0000447331"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        359..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        477..497
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        521..541
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   548 AA;  56650 MW;  3B830A76B619E244 CRC64;
     MSSTVIDRAR PAGHRAPHRG SGFTGTLGLL RLYLRRDRVS LPLWVLLLSV PLATVYIASV
     ETVYPDRSAR AAAAAAIMAS PAQRALYGPV YNDSLGAVGI WKAGMFHTLI AVAVILTVIR
     HTRADEESGR AELIDSTVVG RYANLTGALL LSFGASIATG AIGALGLLAT DVAPAGSVAF
     GVALAASGMV FTAVAAVAAQ LSPSARFTRA VAFAVLGTAF ALRAIGDAGS GTLSWCSPLG
     WSLQVRPYAG ERWWVLLLSL ATAAVLTVLA YRLRAGRDVG AGLIAERPGA GTAGPMLSEP
     FGLAWRLNRG SLLLWTVGLC LYGLVMGSVV HGIGDQLGDN TAVRDIVTRM GGTGALEQAF
     LALAFTMIGM VAAAFAVSLT LRLHQEETGL RAETLLAGAV SRTHWLASHL AMALAGSAVA
     TLISGVAAGL AYGMTVGDVG GKLPTVVGTA AVQLPAVWLL SAVTVGLFGL APRFTPVAWG
     VLVGFIALYL LGSLAGFPQM LLNLEPFAHI PRVGGGDFTA VPLLWLLAID AALITLGAMA
     FRRRDVRC