ID   MEPR_PSEPU              Reviewed;         210 AA.
AC   P0C068;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Probable HTH-type transcriptional regulator MepR;
DE   AltName: Full=Multidrug/solvent efflux pump mepABC operon repressor;
GN   Name=mepR;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KT2442-TOL;
RX   PubMed=9827328; DOI=10.1007/s007920050084;
RA   Fukumori F., Hirayama H., Takami H., Inoue A., Horikoshi K.;
RT   "Isolation and transposon mutagenesis of a Pseudomonas putida KT2442
RT   toluene-resistant variant: involvement of an efflux system in solvent
RT   resistance.";
RL   Extremophiles 2:395-400(1998).
CC   -!- FUNCTION: Probable regulatory protein for the mepABC organic solvent
CC       and antibiotic efflux pump operon. May function as a repressor (By
CC       similarity). {ECO:0000250}.
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DR   AlphaFoldDB; P0C068; -.
DR   SMR; P0C068; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR013572; Tscrpt_reg_MAATS_C.
DR   Pfam; PF08361; TetR_C_2; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..210
FT                   /note="Probable HTH-type transcriptional regulator MepR"
FT                   /id="PRO_0000070625"
FT   DOMAIN          10..70
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   210 AA;  23738 MW;  2E302B186B47C6F0 CRC64;
     MVRRTKEEAQ ETPAQIIEAA ERAFYKRGVA RTTLADIAEL AGVTRGAIYW HFNNKAELVQ
     ALLDSLHETH DHLARASESE DELDPLGCMR KLLLQVFNEL VLDARTRRIN EILHHKCEFT
     DDMCEIRQQR QSAVLDCHKG ITLALANAVR RGQLPGELDV ERAAVAMFAY VDGLIGRWLL
     LPDSVDLLGD VEKWVDTGLD MLRLSPALRK