ID   MER11_EUPRA             Reviewed;          39 AA.
AC   P26887;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Mating pheromone Er-11;
DE   AltName: Full=Euplomone R11;
GN   Name=MAT11;
OS   Euplotes raikovi.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Hypotrichia; Euplotida; Euplotidae; Euplotes.
OX   NCBI_TaxID=5938;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=13;
RX   PubMed=1549567; DOI=10.1073/pnas.89.6.2071;
RA   Raffioni S., Miceli C., Vallesi A., Chowdhury S.K., Chait B.T.,
RA   Luporini P., Bradshaw R.A.;
RT   "Primary structure of Euplotes raikovi pheromones: comparison of five
RT   sequences of pheromones from cells with variable mating interactions.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:2071-2075(1992).
RN   [2]
RP   STRUCTURE BY NMR.
RX   PubMed=8844842; DOI=10.1002/pro.5560050807;
RA   Luginbuhl P., Wu J., Zerbe O., Ortenzi C., Luporini P., Wuethrich K.;
RT   "The NMR solution structure of the pheromone Er-11 from the ciliated
RT   protozoan Euplotes raikovi.";
RL   Protein Sci. 5:1512-1522(1996).
CC   -!- FUNCTION: Mating ciliate pheromones (or gamones) are diffusible
CC       extracellular communication signals that distinguish different
CC       intraspecific classes of cells commonly referred to as 'mating types'.
CC       They prepare the latter for conjugation by changing their cell surface
CC       properties.
CC   -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   PIR; B41933; B41933.
DR   PDB; 1ERY; NMR; -; A=1-39.
DR   PDBsum; 1ERY; -.
DR   AlphaFoldDB; P26887; -.
DR   SMR; P26887; -.
DR   EvolutionaryTrace; P26887; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005186; F:pheromone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009064; Pheromone_protoz.
DR   InterPro; IPR036245; Pheromone_protoz_sf.
DR   Pfam; PF06360; E_raikovi_mat; 1.
DR   SUPFAM; SSF47014; SSF47014; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Disulfide bond; Pheromone;
KW   Secreted.
FT   PEPTIDE         1..39
FT                   /note="Mating pheromone Er-11"
FT                   /id="PRO_0000044736"
FT   DISULFID        3..19
FT   DISULFID        10..34
FT   DISULFID        15..26
FT   HELIX           2..8
FT                   /evidence="ECO:0007829|PDB:1ERY"
FT   HELIX           12..18
FT                   /evidence="ECO:0007829|PDB:1ERY"
FT   HELIX           20..22
FT                   /evidence="ECO:0007829|PDB:1ERY"
FT   HELIX           23..33
FT                   /evidence="ECO:0007829|PDB:1ERY"
SQ   SEQUENCE   39 AA;  4209 MW;  D81707F8AFB3788D CRC64;
     DECANAAAQC SITLCNLYCG PLIEICELTV MQNCEPPFS