ID   MER22_EUPRA             Reviewed;          37 AA.
AC   P58548;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Mating pheromone Er-22;
DE   AltName: Full=Euplomone R22;
GN   Name=MAT22;
OS   Euplotes raikovi.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Hypotrichia; Euplotida; Euplotidae; Euplotes.
OX   NCBI_TaxID=5938;
RN   [1]
RP   STRUCTURE BY NMR.
RX   PubMed=11246857; DOI=10.1023/a:1008332922256;
RA   Liu A., Luginbuhl P., Zerbe O., Ortenzi C., Luporini P., Wuethrich K.;
RT   "NMR structure of the pheromone Er-22 from Euplotes raikovi.";
RL   J. Biomol. NMR 19:75-78(2001).
CC   -!- FUNCTION: Mating ciliate pheromones (or gamones) are diffusible
CC       extracellular communication signals that distinguish different
CC       intraspecific classes of cells commonly referred to as 'mating types'.
CC       They prepare the latter for conjugation by changing their cell surface
CC       properties.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   PDB; 1HD6; NMR; -; A=1-37.
DR   PDBsum; 1HD6; -.
DR   AlphaFoldDB; P58548; -.
DR   SMR; P58548; -.
DR   EvolutionaryTrace; P58548; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005186; F:pheromone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009064; Pheromone_protoz.
DR   InterPro; IPR036245; Pheromone_protoz_sf.
DR   Pfam; PF06360; E_raikovi_mat; 1.
DR   SUPFAM; SSF47014; SSF47014; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Pheromone; Secreted.
FT   PEPTIDE         1..37
FT                   /note="Mating pheromone Er-22"
FT                   /id="PRO_0000044737"
FT   DISULFID        3..18
FT   DISULFID        10..32
FT   DISULFID        15..24
FT   HELIX           2..9
FT                   /evidence="ECO:0007829|PDB:1HD6"
FT   HELIX           12..15
FT                   /evidence="ECO:0007829|PDB:1HD6"
FT   HELIX           21..31
FT                   /evidence="ECO:0007829|PDB:1HD6"
SQ   SEQUENCE   37 AA;  3939 MW;  5F6282C7379C9A2E CRC64;
     DICDIAIAQC SLTLCQDCEN TPICELAVKG SCPPPWS