ID   MER23_EUPRA             Reviewed;          51 AA.
AC   P58547;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Mating pheromone Er-23;
DE   AltName: Full=Euplomone R23;
GN   Name=MAT23;
OS   Euplotes raikovi.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Hypotrichia; Euplotida; Euplotidae; Euplotes.
OX   NCBI_TaxID=5938;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=11908903; DOI=10.1111/j.1550-7408.2002.tb00347.x;
RA   Di Giuseppe G., Miceli C., Zahn R., Damberger F., Wuethrich K.,
RA   Luporini P.;
RT   "A structurally deviant member of the Euplotes raikovi pheromone family:
RT   Er-23.";
RL   J. Eukaryot. Microbiol. 49:86-92(2002).
RN   [2]
RP   STRUCTURE BY NMR.
RX   PubMed=11700049; DOI=10.1006/jmbi.2001.5099;
RA   Zahn R., Damberger F., Ortenzi C., Luporini P., Wuethrich K.;
RT   "NMR structure of the Euplotes raikovi pheromone Er-23 and identification
RT   of its five disulfide bonds.";
RL   J. Mol. Biol. 313:923-931(2001).
CC   -!- FUNCTION: Mating ciliate pheromones (or gamones) are diffusible
CC       extracellular communication signals that distinguish different
CC       intraspecific classes of cells commonly referred to as 'mating types'.
CC       They prepare the latter for conjugation by changing their cell surface
CC       properties.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   PDB; 1HA8; NMR; -; A=1-51.
DR   PDBsum; 1HA8; -.
DR   AlphaFoldDB; P58547; -.
DR   BMRB; P58547; -.
DR   SMR; P58547; -.
DR   EvolutionaryTrace; P58547; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0000772; F:mating pheromone activity; IEA:InterPro.
DR   Gene3D; 1.10.10.190; -; 1.
DR   InterPro; IPR016057; Pheromone_Er2/Er23_protoz.
DR   InterPro; IPR016056; Pheromone_Er23_protoz.
DR   SUPFAM; SSF69964; SSF69964; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Disulfide bond; Pheromone;
KW   Secreted.
FT   CHAIN           1..51
FT                   /note="Mating pheromone Er-23"
FT                   /id="PRO_0000186198"
FT   DISULFID        3..24
FT   DISULFID        6..16
FT   DISULFID        13..47
FT   DISULFID        27..40
FT   DISULFID        35..51
FT   HELIX           2..8
FT                   /evidence="ECO:0007829|PDB:1HA8"
FT   HELIX           14..17
FT                   /evidence="ECO:0007829|PDB:1HA8"
FT   TURN            18..21
FT                   /evidence="ECO:0007829|PDB:1HA8"
FT   TURN            24..28
FT                   /evidence="ECO:0007829|PDB:1HA8"
FT   STRAND          34..38
FT                   /evidence="ECO:0007829|PDB:1HA8"
FT   HELIX           41..47
FT                   /evidence="ECO:0007829|PDB:1HA8"
SQ   SEQUENCE   51 AA;  5105 MW;  A2E2CDDE41902014 CRC64;
     GECEQCFSDG GDCTTCFNNG TGPCANCLAG YPAGCSNSDC TAFLSQCYGG C