ID   MER3_EUPOC              Reviewed;         151 AA.
AC   P28717;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 2.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Mating pheromone 3;
DE   Flags: Precursor;
GN   Name=PHR3;
OS   Euplotoides octocarinatus (Freshwater ciliate) (Euplotes octocarinatus).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Hypotrichia; Euplotida; Euplotidae; Euplotes.
OX   NCBI_TaxID=2716877;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 53-88.
RC   STRAIN=3(58)-IX;
RX   PubMed=1902568; DOI=10.1073/pnas.88.9.3758;
RA   Meyer F., Schmidt H.J., Pluemper E., Hasilik A., Mersmann G., Meyer H.E.,
RA   Engstroem A., Heckmann K.;
RT   "UGA is translated as cysteine in pheromone 3 of Euplotes octocarinatus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:3758-3761(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 53-151.
RC   STRAIN=3(58)-IX;
RX   PubMed=1765269; DOI=10.1016/0378-1119(91)90613-g;
RA   Bruenen-Nieweler C., Schmidt H.J., Heckmann K.;
RT   "Two introns in the pheromone 3-encoding gene of Euplotes octocarinatus.";
RL   Gene 109:233-237(1991).
CC   -!- FUNCTION: Mating ciliate pheromones (or gamones) are diffusible
CC       extracellular communication signals that distinguish different
CC       intraspecific classes of cells commonly referred to as 'mating types'.
CC       They prepare the latter for conjugation by changing their cell surface
CC       properties.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M63389; AAB02123.1; ALT_SEQ; mRNA.
DR   EMBL; X58145; CAA41151.1; -; Genomic_DNA.
DR   PIR; A39389; A39389.
DR   AlphaFoldDB; P28717; -.
DR   SMR; P28717; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005186; F:pheromone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR008612; Mating_pheromone_EUPOC.
DR   Pfam; PF05842; Euplotes_phero; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Pheromone; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   PROPEP          17..52
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000008678"
FT   PEPTIDE         53..151
FT                   /note="Mating pheromone 3"
FT                   /id="PRO_0000008679"
SQ   SEQUENCE   151 AA;  17237 MW;  172D4764D8DCF5AA CRC64;
     MKAIFIILAI LMVTQAFKMT SKVNTKLQSQ IQSKFQSKNK LASTFQTSSQ LKYYCWEEPY
     TSSITGCSTS LACYEASDCS VTGNDQDKCN NVGQNMIDKF FELWGVCIND YETCLQYVDR
     AWIHYSDSEF CGCTNPEQES AFRDAMDCLQ F