ID   MER3_STRLI              Reviewed;         189 AA.
AC   P30343;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Mercury resistance operon ORF3;
DE   Flags: Precursor;
OS   Streptomyces lividans.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1916;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=66 / 1326;
RX   PubMed=1494353; DOI=10.1007/bf00279645;
RA   Sedlmeier R., Altenbuchner J.;
RT   "Cloning and DNA sequence analysis of the mercury resistance genes of
RT   Streptomyces lividans.";
RL   Mol. Gen. Genet. 236:76-85(1992).
CC   -!- FUNCTION: Probable mercury binding protein.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- PTM: Predicted to be exported by the Tat system. The position of the
CC       signal peptide cleavage has not been experimentally proven.
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DR   EMBL; X65467; CAA46464.1; -; Genomic_DNA.
DR   PIR; S30172; S30172.
DR   AlphaFoldDB; P30343; -.
DR   SMR; P30343; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046689; P:response to mercury ion; IEA:UniProtKB-KW.
DR   InterPro; IPR006311; TAT_signal.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF13905; Thioredoxin_8; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS51318; TAT; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   3: Inferred from homology;
KW   Mercuric resistance; Mercury; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /note="Tat-type signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00648"
FT   CHAIN           28..189
FT                   /note="Mercury resistance operon ORF3"
FT                   /id="PRO_0000021669"
FT   DOMAIN          38..189
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
SQ   SEQUENCE   189 AA;  19346 MW;  655E0BB24957C316 CRC64;
     MTSPSPTARR TRLRRRTALA LAAAATAALT LSACGTDTKA NTPATRAGSG NAAAAKADTV
     ALLDDTTLAV PGDKPSALFF FSVGCGECAG GAKSLDKAAQ AFDKAGKKAN FLAVDMDPNE
     SKQTIMQFLD YIKAPALPAT IDKGAALSQR YQVAALSTLI VVAPQGKVTY RATDPSADQI
     QDALKKAGA