ID   MER4_EUPOC              Reviewed;         127 AA.
AC   P28716;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Mating pheromone 4;
DE   Flags: Precursor;
GN   Name=PHR4;
OS   Euplotoides octocarinatus (Freshwater ciliate) (Euplotes octocarinatus).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Hypotrichia; Euplotida; Euplotidae; Euplotes.
OX   NCBI_TaxID=2716877;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND PROTEIN SEQUENCE OF 43-81.
RC   STRAIN=67(3)-X;
RX   PubMed=1395137; DOI=10.1002/dvg.1020130104;
RA   Meyer F., Schmidt H.J., Heckmann K.;
RT   "Pheromone 4 gene of Euplotes octocarinatus.";
RL   Dev. Genet. 13:16-25(1992).
CC   -!- FUNCTION: Mating ciliate pheromones (or gamones) are diffusible
CC       extracellular communication signals that distinguish different
CC       intraspecific classes of cells commonly referred to as 'mating types'.
CC       They prepare the latter for conjugation by changing their cell surface
CC       properties.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   EMBL; X58838; CAA41647.1; -; Genomic_DNA.
DR   EMBL; X58837; CAA41646.1; -; mRNA.
DR   PIR; A48420; A48420.
DR   AlphaFoldDB; P28716; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005186; F:pheromone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR008612; Mating_pheromone_EUPOC.
DR   Pfam; PF05842; Euplotes_phero; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Pheromone; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   PROPEP          17..42
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000008680"
FT   PEPTIDE         43..127
FT                   /note="Mating pheromone 4"
FT                   /id="PRO_0000008681"
SQ   SEQUENCE   127 AA;  14164 MW;  29F32F3DE23DE64F CRC64;
     MKAIFIILAI LMVTQAFKMT SKVKSMNMSR NMSKNTSTLG TKYTYGCPQT NTPTQQDCYD
     AMYYTFMAMC DLYPDPEHPM FPSYDSCQEE SDSADEFYTN QCGCGGYGMA AAHDQVCLLA
     LGVCIPE