MERB1_HUMAN
ID MERB1_HUMAN Reviewed; 204 AA.
AC Q96MC5; O00223; O75769; Q8IZ36; Q96H25;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=bMERB domain-containing protein 1 {ECO:0000305};
GN Name=BMERB1 {ECO:0000312|HGNC:HGNC:19213};
GN Synonyms=C16orf45 {ECO:0000312|HGNC:HGNC:19213};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Stomach;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10493829; DOI=10.1006/geno.1999.5927;
RA Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J.,
RA Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X.,
RA Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C.,
RA Adams M.D.;
RT "Genome duplications and other features in 12 Mb of DNA sequence from human
RT chromosome 16p and 16q.";
RL Genomics 60:295-308(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Muscle, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96MC5; Q8WZA2: RAPGEF4; NbExp=4; IntAct=EBI-718468, EBI-948476;
CC Q96MC5; Q99081: TCF12; NbExp=3; IntAct=EBI-718468, EBI-722877;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96MC5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96MC5-2; Sequence=VSP_047232;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC31663.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK057180; BAB71376.1; -; mRNA.
DR EMBL; U95740; AAC31663.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC008967; AAH08967.2; -; mRNA.
DR EMBL; BC023603; AAH23603.2; -; mRNA.
DR CCDS; CCDS10561.1; -. [Q96MC5-1]
DR CCDS; CCDS45422.1; -. [Q96MC5-2]
DR RefSeq; NP_001135941.1; NM_001142469.1. [Q96MC5-2]
DR RefSeq; NP_149978.1; NM_033201.2. [Q96MC5-1]
DR AlphaFoldDB; Q96MC5; -.
DR SMR; Q96MC5; -.
DR BioGRID; 124644; 36.
DR IntAct; Q96MC5; 23.
DR STRING; 9606.ENSP00000300006; -.
DR iPTMnet; Q96MC5; -.
DR PhosphoSitePlus; Q96MC5; -.
DR BioMuta; C16orf45; -.
DR DMDM; 68565261; -.
DR jPOST; Q96MC5; -.
DR MassIVE; Q96MC5; -.
DR MaxQB; Q96MC5; -.
DR PaxDb; Q96MC5; -.
DR PeptideAtlas; Q96MC5; -.
DR PRIDE; Q96MC5; -.
DR ProteomicsDB; 77332; -. [Q96MC5-1]
DR Antibodypedia; 51073; 66 antibodies from 18 providers.
DR DNASU; 89927; -.
DR Ensembl; ENST00000300006.9; ENSP00000300006.4; ENSG00000166780.11. [Q96MC5-1]
DR Ensembl; ENST00000452191.6; ENSP00000408976.2; ENSG00000166780.11. [Q96MC5-2]
DR Ensembl; ENST00000610499.2; ENSP00000477880.1; ENSG00000278823.4. [Q96MC5-2]
DR Ensembl; ENST00000615273.4; ENSP00000483858.1; ENSG00000278823.4. [Q96MC5-1]
DR GeneID; 89927; -.
DR KEGG; hsa:89927; -.
DR MANE-Select; ENST00000300006.9; ENSP00000300006.4; NM_033201.3; NP_149978.1.
DR UCSC; uc002ddo.4; human. [Q96MC5-1]
DR CTD; 89927; -.
DR DisGeNET; 89927; -.
DR GeneCards; BMERB1; -.
DR HGNC; HGNC:19213; BMERB1.
DR HPA; ENSG00000166780; Tissue enhanced (brain).
DR neXtProt; NX_Q96MC5; -.
DR OpenTargets; ENSG00000166780; -.
DR PharmGKB; PA134973206; -.
DR VEuPathDB; HostDB:ENSG00000166780; -.
DR eggNOG; ENOG502RC9C; Eukaryota.
DR GeneTree; ENSGT00440000038745; -.
DR HOGENOM; CLU_123952_0_0_1; -.
DR InParanoid; Q96MC5; -.
DR OMA; ATQCSIM; -.
DR PhylomeDB; Q96MC5; -.
DR TreeFam; TF331543; -.
DR PathwayCommons; Q96MC5; -.
DR SignaLink; Q96MC5; -.
DR BioGRID-ORCS; 89927; 15 hits in 1043 CRISPR screens.
DR ChiTaRS; C16orf45; human.
DR GenomeRNAi; 89927; -.
DR Pharos; Q96MC5; Tbio.
DR PRO; PR:Q96MC5; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96MC5; protein.
DR Bgee; ENSG00000166780; Expressed in superior frontal gyrus and 102 other tissues.
DR ExpressionAtlas; Q96MC5; baseline and differential.
DR Genevisible; Q96MC5; HS.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0021814; P:cell motility involved in cerebral cortex radial glia guided migration; IEA:Ensembl.
DR GO; GO:0007019; P:microtubule depolymerization; IEA:Ensembl.
DR GO; GO:0021822; P:negative regulation of cell motility involved in cerebral cortex radial glia guided migration; IEA:Ensembl.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; IBA:GO_Central.
DR InterPro; IPR022735; bMERB_dom.
DR InterPro; IPR040127; C16orf45-like.
DR PANTHER; PTHR22704; PTHR22704; 1.
DR Pfam; PF12130; DUF3585; 1.
DR PROSITE; PS51848; BMERB; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..204
FT /note="bMERB domain-containing protein 1"
FT /id="PRO_0000079281"
FT DOMAIN 3..150
FT /note="bMERB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01195"
FT REGION 162..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..36
FT /note="MELKQSLSTHLEAEKPLRRYGAVEETAWKTERLGRN -> MWGDLTETGCMG
FT RRSAKKD (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_047232"
SQ SEQUENCE 204 AA; 23732 MW; 5D702950A7744A5F CRC64;
MELKQSLSTH LEAEKPLRRY GAVEETAWKT ERLGRNQLDI ISMAETTMMP EEIELEMAKI
QRLREVLVRR ESELRFMMDD IQLCKDIMDL KQELQNLVAI PEKEKTKLQK QREDELIQKI
HKLVQKRDFL VDDAEVERLR EQEEDKEMAD FLRIKLKPLD KVTKSPASSR AEKKAEPPPS
KPTVAKTGLA LIKDCCGATQ CNIM
