MERB1_MOUSE
ID MERB1_MOUSE Reviewed; 203 AA.
AC Q8R1Y2; Q3UVX0;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=bMERB domain-containing protein 1 {ECO:0000305};
DE AltName: Full=Uncharacterized protein C16orf45 homolog;
GN Name=Bmerb1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Diencephalon, and Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK035868; BAC29221.1; -; mRNA.
DR EMBL; AK076136; BAC36211.1; -; mRNA.
DR EMBL; AK136859; BAE23149.1; -; mRNA.
DR EMBL; BC022741; AAH22741.1; -; mRNA.
DR CCDS; CCDS27971.1; -.
DR RefSeq; NP_653101.1; NM_144518.3.
DR AlphaFoldDB; Q8R1Y2; -.
DR SMR; Q8R1Y2; -.
DR STRING; 10090.ENSMUSP00000062758; -.
DR iPTMnet; Q8R1Y2; -.
DR PhosphoSitePlus; Q8R1Y2; -.
DR MaxQB; Q8R1Y2; -.
DR PaxDb; Q8R1Y2; -.
DR PRIDE; Q8R1Y2; -.
DR Antibodypedia; 51073; 66 antibodies from 18 providers.
DR DNASU; 67254; -.
DR Ensembl; ENSMUST00000056521; ENSMUSP00000062758; ENSMUSG00000044117.
DR GeneID; 67254; -.
DR KEGG; mmu:67254; -.
DR UCSC; uc007ygu.1; mouse.
DR CTD; 89927; -.
DR MGI; MGI:1914504; Bmerb1.
DR VEuPathDB; HostDB:ENSMUSG00000044117; -.
DR eggNOG; ENOG502RC9C; Eukaryota.
DR GeneTree; ENSGT00440000038745; -.
DR HOGENOM; CLU_123952_0_0_1; -.
DR InParanoid; Q8R1Y2; -.
DR OMA; ATQCSIM; -.
DR OrthoDB; 1309155at2759; -.
DR PhylomeDB; Q8R1Y2; -.
DR TreeFam; TF331543; -.
DR BioGRID-ORCS; 67254; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Bmerb1; mouse.
DR PRO; PR:Q8R1Y2; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8R1Y2; protein.
DR Bgee; ENSMUSG00000044117; Expressed in medial dorsal nucleus of thalamus and 145 other tissues.
DR ExpressionAtlas; Q8R1Y2; baseline and differential.
DR Genevisible; Q8R1Y2; MM.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:MGI.
DR GO; GO:0021814; P:cell motility involved in cerebral cortex radial glia guided migration; IMP:MGI.
DR GO; GO:0007019; P:microtubule depolymerization; IMP:MGI.
DR GO; GO:0021822; P:negative regulation of cell motility involved in cerebral cortex radial glia guided migration; IMP:MGI.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; IMP:MGI.
DR InterPro; IPR022735; bMERB_dom.
DR InterPro; IPR040127; C16orf45-like.
DR PANTHER; PTHR22704; PTHR22704; 1.
DR Pfam; PF12130; DUF3585; 1.
DR PROSITE; PS51848; BMERB; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..203
FT /note="bMERB domain-containing protein 1"
FT /id="PRO_0000079282"
FT DOMAIN 3..149
FT /note="bMERB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01195"
FT REGION 161..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 203 AA; 23465 MW; C40E0DEA0600ADB3 CRC64;
MELKQSLSVH LEAEKPLRRY GAVEETAWKA EGLGSQLDII SMAETSMMPE EIELEMAKIQ
RLREVLVRRE SELRFMMDDI QLCKDIMDLK QELQNLVAIP EKEKTKLQKQ REDELIQKIH
RLVQKRDFLV DDAEVERLRE QEEDKEMADF LRIKLKPLDK VTKTSASSRA EKKAEPPPSK
PTVAKTGLAL IKDCCGTTQC NIM
