ID   MERB_SERMA              Reviewed;         212 AA.
AC   P08664;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Alkylmercury lyase;
DE            EC=4.99.1.2;
DE   AltName: Full=Organomercurial lyase;
GN   Name=merB;
OS   Serratia marcescens.
OG   Plasmid pDU1358.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3033633; DOI=10.1073/pnas.84.10.3112;
RA   Griffin H.G., Foster T.J., Silver S., Misra T.K.;
RT   "Cloning and DNA sequence of the mercuric- and organomercurial-resistance
RT   determinants of plasmid pDU1358.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:3112-3116(1987).
CC   -!- FUNCTION: Cleaves the carbon-mercury bond of organomercurials such as
CC       phenylmercuric acetate. One product is Hg(2+), which is subsequently
CC       detoxified by the mercuric reductase.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an alkylmercury + H(+) = an alkane + Hg(2+);
CC         Xref=Rhea:RHEA:18777, ChEBI:CHEBI:15378, ChEBI:CHEBI:16793,
CC         ChEBI:CHEBI:18310, ChEBI:CHEBI:83725; EC=4.99.1.2;
CC   -!- SIMILARITY: Belongs to the MerB family. {ECO:0000305}.
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DR   EMBL; M15049; AAA88369.1; -; Genomic_DNA.
DR   PIR; B29010; B29010.
DR   RefSeq; WP_000761850.1; NZ_LR890658.1.
DR   AlphaFoldDB; P08664; -.
DR   BMRB; P08664; -.
DR   SMR; P08664; -.
DR   BRENDA; 4.99.1.2; 5690.
DR   GO; GO:0018836; F:alkylmercury lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046413; P:organomercury catabolic process; IEA:InterPro.
DR   GO; GO:0046689; P:response to mercury ion; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00714; MerB; 1.
DR   InterPro; IPR004927; MerB.
DR   InterPro; IPR024259; MerB_HTH_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF12324; HTH_15; 1.
DR   Pfam; PF03243; MerB; 1.
DR   PIRSF; PIRSF001458; MerB; 1.
DR   PRINTS; PR01699; ORGNOHGLYASE.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Lyase; Mercuric resistance; Mercury; Plasmid.
FT   CHAIN           1..212
FT                   /note="Alkylmercury lyase"
FT                   /id="PRO_0000220360"
SQ   SEQUENCE   212 AA;  23078 MW;  165E6640E11950E2 CRC64;
     MKLAPYILER LTSVNRTNGT ADLLVPLLRE LAKGRPVSRT TLAGILDWPA ERVAAVLEQA
     TSTEYDKDGN IIGYGLTLRE TSYVFEIDDR RLYAWCALDT LIFPALIGRT ARVSSHCAAT
     GAPVSLTVSP SEIQAVEPAG MAVSLVLPQE AADVRQSFCC HVHFFASVPT AEDWASKHQG
     LEGLAIVSVH EAFGLGQEFN RHLLQTMSSR TP