ID   MERB_STRLI              Reviewed;         215 AA.
AC   P30342;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Alkylmercury lyase;
DE            EC=4.99.1.2;
DE   AltName: Full=Organomercurial lyase;
GN   Name=merB;
OS   Streptomyces lividans.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1916;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=66 / 1326;
RX   PubMed=1494353; DOI=10.1007/bf00279645;
RA   Sedlmeier R., Altenbuchner J.;
RT   "Cloning and DNA sequence analysis of the mercury resistance genes of
RT   Streptomyces lividans.";
RL   Mol. Gen. Genet. 236:76-85(1992).
CC   -!- FUNCTION: Cleaves the carbon-mercury bond of organomercurials such as
CC       phenylmercuric acetate. One product is Hg(2+), which is subsequently
CC       detoxified by the mercuric reductase.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an alkylmercury + H(+) = an alkane + Hg(2+);
CC         Xref=Rhea:RHEA:18777, ChEBI:CHEBI:15378, ChEBI:CHEBI:16793,
CC         ChEBI:CHEBI:18310, ChEBI:CHEBI:83725; EC=4.99.1.2;
CC   -!- SIMILARITY: Belongs to the MerB family. {ECO:0000305}.
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DR   EMBL; X65467; CAA46461.1; -; Genomic_DNA.
DR   PIR; S30169; S30169.
DR   AlphaFoldDB; P30342; -.
DR   SMR; P30342; -.
DR   GO; GO:0018836; F:alkylmercury lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046413; P:organomercury catabolic process; IEA:InterPro.
DR   GO; GO:0046689; P:response to mercury ion; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00714; MerB; 1.
DR   InterPro; IPR004927; MerB.
DR   InterPro; IPR024259; MerB_HTH_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF12324; HTH_15; 1.
DR   Pfam; PF03243; MerB; 1.
DR   PIRSF; PIRSF001458; MerB; 1.
DR   PRINTS; PR01699; ORGNOHGLYASE.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Lyase; Mercuric resistance; Mercury.
FT   CHAIN           1..215
FT                   /note="Alkylmercury lyase"
FT                   /id="PRO_0000220363"
SQ   SEQUENCE   215 AA;  23026 MW;  9FC8A931F9EA1012 CRC64;
     MDSQAQQLAT RLTTAFNGGG AASSRPWLWR PLLQLLAQGR PVTVEQIAQA TDRTPDQVRE
     ALAANPDTEY DERGRITGSG LTQNPTPHHF EVDGQQLYTW CALDTLIFPA ILGRPAHVTS
     PCHATGTPVR LTVEPDQVTS VEPATAVVSI VTPDAPASIR TAFCNQVHFF ATPDAGKGWL
     EEHPVATVLP VADAYQLGRP LTEALLTGDT PPGCC