ID   MERD_PSEAI              Reviewed;         121 AA.
AC   P06689;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=HTH-type transcriptional regulator MerD;
DE   AltName: Full=Mercuric resistance protein MerD;
GN   Name=merD;
OS   Pseudomonas aeruginosa.
OG   Plasmid pVS1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TRANSPOSON=Tn501;
RX   PubMed=3007931; DOI=10.1007/bf00330531;
RA   Brown N.L., Misra T.K., Winnie J.N., Schmidt A., Seiff M., Silver S.;
RT   "The nucleotide sequence of the mercuric resistance operons of plasmid R100
RT   and transposon Tn501: further evidence for mer genes which enhance the
RT   activity of the mercuric ion detoxification system.";
RL   Mol. Gen. Genet. 202:143-151(1986).
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DR   EMBL; Z00027; CAA77324.1; -; Genomic_DNA.
DR   PIR; C29503; C29503.
DR   RefSeq; WP_032488411.1; NZ_UAWV01000011.1.
DR   AlphaFoldDB; P06689; -.
DR   SMR; P06689; -.
DR   eggNOG; COG0789; Bacteria.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0046689; P:response to mercury ion; IEA:UniProtKB-KW.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR011797; MerD.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   Pfam; PF13411; MerR_1; 1.
DR   PRINTS; PR00040; HTHMERR.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   TIGRFAMs; TIGR02054; MerD; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Mercuric resistance; Plasmid; Transcription;
KW   Transcription regulation; Transposable element.
FT   CHAIN           1..121
FT                   /note="HTH-type transcriptional regulator MerD"
FT                   /id="PRO_0000098130"
FT   DOMAIN          3..72
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        6..25
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
SQ   SEQUENCE   121 AA;  13014 MW;  AEB2C562D4E3CAF7 CRC64;
     MNAYPVSRLA LDAGVSVHIV RDYLLRGLLR PVACTPGGYG LFDDAALQRL CFVRAAFEAG
     IGLDALARLC RALDAADGDE AAAQLALLRQ FVERRREALA DLEVQLATLP TEPAQHAESL
     P