ID   MERD_SALTI              Reviewed;         121 AA.
AC   P0A2Q6; P94703;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=HTH-type transcriptional regulator MerD;
DE   AltName: Full=Mercuric resistance protein MerD;
GN   Name=merD; OrderedLocusNames=HCM1.159;
OS   Salmonella typhi.
OG   Plasmid pHCM1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
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DR   EMBL; AL513383; CAD09751.1; -; Genomic_DNA.
DR   RefSeq; NP_569365.1; NC_003384.1.
DR   RefSeq; WP_001277466.1; NZ_FFLT01000030.1.
DR   AlphaFoldDB; P0A2Q6; -.
DR   SMR; P0A2Q6; -.
DR   KEGG; sty:HCM1.159; -.
DR   PATRIC; fig|220341.7.peg.5193; -.
DR   HOGENOM; CLU_140237_0_0_6; -.
DR   Proteomes; UP000000541; Plasmid pHCM1.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0046689; P:response to mercury ion; IEA:UniProtKB-KW.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR011797; MerD.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   Pfam; PF13411; MerR_1; 1.
DR   PRINTS; PR00040; HTHMERR.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   TIGRFAMs; TIGR02054; MerD; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Mercuric resistance; Plasmid; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..121
FT                   /note="HTH-type transcriptional regulator MerD"
FT                   /id="PRO_0000098132"
FT   DOMAIN          3..72
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        6..25
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
SQ   SEQUENCE   121 AA;  13026 MW;  BD7C19ACA44C969B CRC64;
     MSAYTVSRLA LDAGVSVHIV RDYLLRGLLR PVAYTTGGYG LFDDTALQRL RFVRAAFEAG
     IGLDALARLC RALDAADGDG ASAQLAVLRQ LVERRREALA SLEMQLAAMP TEPAQHAESL
     P