ID   MERD_SERMA              Reviewed;         121 AA.
AC   P08654;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=HTH-type transcriptional regulator MerD;
DE   AltName: Full=Mercuric resistance protein MerD;
GN   Name=merD;
OS   Serratia marcescens.
OG   Plasmid pDU1358.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3033633; DOI=10.1073/pnas.84.10.3112;
RA   Griffin H.G., Foster T.J., Silver S., Misra T.K.;
RT   "Cloning and DNA sequence of the mercuric- and organomercurial-resistance
RT   determinants of plasmid pDU1358.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:3112-3116(1987).
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DR   EMBL; M15049; AAA88370.1; -; Genomic_DNA.
DR   PIR; C29010; C29010.
DR   RefSeq; WP_000995361.1; NZ_KM406489.1.
DR   RefSeq; YP_006964542.1; NC_019344.1.
DR   AlphaFoldDB; P08654; -.
DR   SMR; P08654; -.
DR   PRIDE; P08654; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0046689; P:response to mercury ion; IEA:UniProtKB-KW.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR011797; MerD.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   Pfam; PF13411; MerR_1; 1.
DR   PRINTS; PR00040; HTHMERR.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   TIGRFAMs; TIGR02054; MerD; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Mercuric resistance; Plasmid; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..121
FT                   /note="HTH-type transcriptional regulator MerD"
FT                   /id="PRO_0000098133"
FT   DOMAIN          3..72
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        6..25
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
SQ   SEQUENCE   121 AA;  12954 MW;  5FF0C68DDE1F4103 CRC64;
     MNAYTVSRLA LDAGVSVHIV RDYLLRGLLR PVACTTGGYG LFDDAALQRL CFVRAAFEAG
     IGLGALARLC RALDAANCDE TAAQLAVLRQ FVERRREALA NLEVQLAAMP TAPAQHAESL
     P