ID   MERD_SHIFL              Reviewed;         120 AA.
AC   P20102;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=HTH-type transcriptional regulator MerD;
DE   AltName: Full=Mercuric resistance protein MerD;
GN   Name=merD;
OS   Shigella flexneri.
OG   Plasmid IncFII R100 (NR1), and Plasmid pLV501.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3007931; DOI=10.1007/bf00330531;
RA   Brown N.L., Misra T.K., Winnie J.N., Schmidt A., Seiff M., Silver S.;
RT   "The nucleotide sequence of the mercuric resistance operons of plasmid R100
RT   and transposon Tn501: further evidence for mer genes which enhance the
RT   activity of the mercuric ion detoxification system.";
RL   Mol. Gen. Genet. 202:143-151(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pLV501;
RA   Fletcher J.N., Hart C.A., Batt R.M., Saunders J.R.;
RT   "The epithelial cell invasive determinant of enteropathogenic Escherichia
RT   coli plasmid pLV501 is encoded on Tn4355, a novel Tn21-type transposon.";
RL   Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-6.
RX   PubMed=2989109; DOI=10.1016/0378-1119(85)90134-9;
RA   Misra T.K., Brown N.L., Haberstroh L., Schmidt A., Goddette D., Silver S.;
RT   "Mercuric reductase structural genes from plasmid R100 and transposon
RT   Tn501: functional domains of the enzyme.";
RL   Gene 34:253-262(1985).
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DR   EMBL; J01730; AAA92264.1; -; Genomic_DNA.
DR   EMBL; X03405; CAA27139.1; -; Genomic_DNA.
DR   EMBL; L29404; AAA83540.2; -; Genomic_DNA.
DR   PIR; A29503; A29503.
DR   AlphaFoldDB; P20102; -.
DR   SMR; P20102; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0046689; P:response to mercury ion; IEA:UniProtKB-KW.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR011797; MerD.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   Pfam; PF13411; MerR_1; 1.
DR   PRINTS; PR00040; HTHMERR.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   TIGRFAMs; TIGR02054; MerD; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Mercuric resistance; Plasmid; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..120
FT                   /note="HTH-type transcriptional regulator MerD"
FT                   /id="PRO_0000098134"
FT   DOMAIN          3..72
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        6..25
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   CONFLICT        88
FT                   /note="V -> L (in Ref. 2; AAA83540)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   120 AA;  12724 MW;  EB5716CA4138EB4D CRC64;
     MSAYTVSQLA HNAGVSVHIV RDYLVRGLLR PVACTTGGYG VFDDAALQRL CFVRAAFEAG
     IGLDALARLC RALDAADGAQ AAAQLAVVRQ LVERRRAALA HLDAQLASMP AERAHEEALP