ID   MERE_PSEAI              Reviewed;          78 AA.
AC   P06690;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Broad mercury transporter MerE {ECO:0000250|UniProtKB:Q7AKA4};
GN   Name=merE;
OS   Pseudomonas aeruginosa.
OG   Plasmid pVS1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TRANSPOSON=Tn501;
RX   PubMed=3007931; DOI=10.1007/bf00330531;
RA   Brown N.L., Misra T.K., Winnie J.N., Schmidt A., Seiff M., Silver S.;
RT   "The nucleotide sequence of the mercuric resistance operons of plasmid R100
RT   and transposon Tn501: further evidence for mer genes which enhance the
RT   activity of the mercuric ion detoxification system.";
RL   Mol. Gen. Genet. 202:143-151(1986).
CC   -!- FUNCTION: Broad mercury transporter that mediates the transport of both
CC       CH(3)Hg(I) and Hg(II) across the membrane.
CC       {ECO:0000250|UniProtKB:Q7AKA4}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:Q7AKA4}; Multi-pass membrane protein
CC       {ECO:0000255}.
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DR   EMBL; Z00027; CAA77325.1; -; Genomic_DNA.
DR   RefSeq; WP_003132004.1; NZ_WXZW01000069.1.
DR   RefSeq; YP_001427360.1; NC_009739.1.
DR   AlphaFoldDB; P06690; -.
DR   GeneID; 61089177; -.
DR   OMA; MNGPERL; -.
DR   PRO; PR:P06690; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015097; F:mercury ion transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR007746; MerE.
DR   Pfam; PF05052; MerE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Mercuric resistance; Plasmid;
KW   Transmembrane; Transmembrane helix; Transport; Transposable element.
FT   CHAIN           1..78
FT                   /note="Broad mercury transporter MerE"
FT                   /id="PRO_0000096426"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   78 AA;  8410 MW;  E1EF23E690CF115D CRC64;
     MNNPERLPSE THKPITGYLW GGLAVLTCPC HLPILAVVLA GTTAGAFLGE HWVIAALGLT
     GLFLLSLSRA LRAFRERE