ID   MERE_SHIFL              Reviewed;          78 AA.
AC   Q7AKA4;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Broad mercury transporter MerE {ECO:0000305};
GN   Name=merE {ECO:0000303|PubMed:19265693};
GN   Synonyms=yadA {ECO:0000312|EMBL:BAA78791.1};
OS   Shigella flexneri.
OG   Plasmid IncFII R100 (NR1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=222 / Serotype 2b;
RA   Sampei G., Mizobuchi K.;
RT   "Organization and diversification of plasmid genomes: complete nucleotide
RT   sequence of the R100 genome.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=19265693; DOI=10.1016/j.febslet.2009.02.039;
RA   Kiyono M., Sone Y., Nakamura R., Pan-Hou H., Sakabe K.;
RT   "The MerE protein encoded by transposon Tn21 is a broad mercury transporter
RT   in Escherichia coli.";
RL   FEBS Lett. 583:1127-1131(2009).
CC   -!- FUNCTION: Broad mercury transporter that mediates the transport of both
CC       CH(3)Hg(I) and Hg(II) across the membrane.
CC       {ECO:0000269|PubMed:19265693}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000269|PubMed:19265693}; Multi-pass membrane protein
CC       {ECO:0000255}.
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DR   EMBL; AP000342; BAA78791.1; -; Genomic_DNA.
DR   RefSeq; NP_052887.1; NC_002134.1.
DR   RefSeq; WP_000993386.1; NZ_CP041619.1.
DR   AlphaFoldDB; Q7AKA4; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015097; F:mercury ion transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR007746; MerE.
DR   Pfam; PF05052; MerE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Mercuric resistance; Plasmid;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..78
FT                   /note="Broad mercury transporter MerE"
FT                   /id="PRO_0000442700"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   78 AA;  8069 MW;  7C605A1DF4A6A478 CRC64;
     MNAPDKLPPE TRQPVSGYLW GALAVLTCPC HLPILAAVLA GTTAGAFLGE HWGVAALALT
     GLFVLAVTRL LRAFRGGS