ID   MERR_SHIFL              Reviewed;         144 AA.
AC   P0A2Q9; P07044;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Mercuric resistance operon regulatory protein;
GN   Name=merR;
OS   Shigella flexneri.
OG   Plasmid IncFII R100 (NR1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TRANSPOSON=Tn21;
RX   PubMed=6530603;
RA   Barrineau P., Gilbert P., Jackson W.J., Jones C.S., Summers A.O.,
RA   Wisdom S.;
RT   "The DNA sequence of the mercury resistance operon of the IncFII plasmid
RT   NR1.";
RL   J. Mol. Appl. Genet. 2:601-619(1984).
CC   -!- FUNCTION: Mediates the mercuric-dependent induction of mercury
CC       resistance operon. In the absence of mercury MerR represses
CC       transcription by binding tightly to the mer operator region; when
CC       mercury is present the dimeric complex binds a single ion and becomes a
CC       potent transcriptional activator, while remaining bound to the mer
CC       site.
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DR   EMBL; K03089; AAB59072.1; -; Genomic_DNA.
DR   RefSeq; WP_000429836.1; NZ_WPET01000167.1.
DR   AlphaFoldDB; P0A2Q9; -.
DR   SMR; P0A2Q9; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045340; F:mercury ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0046689; P:response to mercury ion; IEA:UniProtKB-KW.
DR   CDD; cd04783; HTH_MerR1; 1.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR011794; MerR.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   InterPro; IPR015358; Tscrpt_reg_MerR_DNA-bd.
DR   Pfam; PF00376; MerR; 1.
DR   Pfam; PF09278; MerR-DNA-bind; 1.
DR   PRINTS; PR00040; HTHMERR.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   TIGRFAMs; TIGR02051; MerR; 1.
DR   PROSITE; PS00552; HTH_MERR_1; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Mercuric resistance; Mercury; Metal-binding;
KW   Plasmid; Repressor; Transcription; Transcription regulation;
KW   Transposable element.
FT   CHAIN           1..144
FT                   /note="Mercuric resistance operon regulatory protein"
FT                   /id="PRO_0000098141"
FT   DOMAIN          7..76
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        10..29
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   BINDING         82
FT                   /ligand="Hg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:16793"
FT   BINDING         117
FT                   /ligand="Hg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:16793"
FT   BINDING         126
FT                   /ligand="Hg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:16793"
SQ   SEQUENCE   144 AA;  15905 MW;  8BEEC928A7B83EE9 CRC64;
     MENNLENLTI GVFAKAAGVN VETIRFYQRK GLLREPDKPY GSIRRYGEAD VVRVKFVKSA
     QRLGFSLDEI AELLRLDDGT HCEEASSLAE HKLKDVREKM ADLARMETVL SELVCACHAR
     KGNVSCPLIA SLQGEAGLAR SAMP