ID   MERR_STRLI              Reviewed;         125 AA.
AC   P30346;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Probable mercury resistance operon repressor;
GN   Name=merR;
OS   Streptomyces lividans.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1916;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=66 / 1326;
RX   PubMed=1494353; DOI=10.1007/bf00279645;
RA   Sedlmeier R., Altenbuchner J.;
RT   "Cloning and DNA sequence analysis of the mercury resistance genes of
RT   Streptomyces lividans.";
RL   Mol. Gen. Genet. 236:76-85(1992).
RN   [2]
RP   FUNCTION.
RC   STRAIN=66 / 1326;
RX   PubMed=8676873; DOI=10.1007/bf02172521;
RA   Brunker P., Rother D., Sedlmeier R., Klein J., Mattes R., Altenbuchner J.;
RT   "Regulation of the operon responsible for broad-spectrum mercury resistance
RT   in Streptomyces lividans 1326.";
RL   Mol. Gen. Genet. 251:307-315(1996).
CC   -!- FUNCTION: Negatively regulates the mercuric reductase merA and the
CC       organolyase merB in the absence of mercuric ions.
CC       {ECO:0000269|PubMed:8676873}.
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DR   EMBL; X65467; CAA46462.1; -; Genomic_DNA.
DR   PIR; S30170; S30170.
DR   AlphaFoldDB; P30346; -.
DR   SMR; P30346; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046689; P:response to mercury ion; IEA:UniProtKB-KW.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01022; HTH_5; 1.
DR   PRINTS; PR00778; HTHARSR.
DR   SMART; SM00418; HTH_ARSR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50987; HTH_ARSR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Mercuric resistance; Mercury; Metal-binding; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..125
FT                   /note="Probable mercury resistance operon repressor"
FT                   /id="PRO_0000160623"
FT   DOMAIN          15..109
FT                   /note="HTH arsR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   DNA_BIND        49..68
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   BINDING         69
FT                   /ligand="Hg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:16793"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   BINDING         73
FT                   /ligand="Hg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:16793"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   BINDING         114
FT                   /ligand="Hg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:16793"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
SQ   SEQUENCE   125 AA;  13484 MW;  17FE68AA9A314461 CRC64;
     MKSPALAGSL ATAEVPCTHP DTTARFFRAL ADPTRLKLLQ FILRGERTSA ECVEHAGISQ
     PRVSVHLSCL VDCGYVSARR DGKKLRYSVG DPRVADLVML ARCLAADNAA ALDCCTRIPG
     EGEQR