MES12_ARATH
ID MES12_ARATH Reviewed; 349 AA.
AC Q940H7; Q9T0E9; Q9T0F0;
DT 11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Putative methylesterase 12, chloroplastic {ECO:0000303|PubMed:18467465};
DE Short=AtMES12 {ECO:0000303|PubMed:18467465};
DE EC=3.1.1.- {ECO:0000250|UniProtKB:Q9SG92};
DE Flags: Precursor;
GN Name=MES12 {ECO:0000303|PubMed:18467465};
GN OrderedLocusNames=At4g09900/At4g09910; ORFNames=T5L19.30/T5L19.40;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=18467465; DOI=10.1104/pp.108.118224;
RA Yang Y., Xu R., Ma C.J., Vlot A.C., Klessig D.F., Pichersky E.;
RT "Inactive methyl indole-3-acetic acid ester can be hydrolyzed and activated
RT by several esterases belonging to the AtMES esterase family of
RT Arabidopsis.";
RL Plant Physiol. 147:1034-1045(2008).
CC -!- FUNCTION: Putative methylesterase.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Methylesterase
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB39614.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At4g09900 and At4g09910.; Evidence={ECO:0000305};
CC Sequence=CAB39615.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At4g09900 and At4g09910.; Evidence={ECO:0000305};
CC Sequence=CAB78113.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At4g09900 and At4g09910.; Evidence={ECO:0000305};
CC Sequence=CAB78114.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At4g09900 and At4g09910.; Evidence={ECO:0000305};
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DR EMBL; AL049481; CAB39614.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL049481; CAB39615.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161516; CAB78113.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161516; CAB78114.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE82811.1; -; Genomic_DNA.
DR EMBL; AY054619; AAK96810.1; -; mRNA.
DR EMBL; AY081515; AAM10077.1; -; mRNA.
DR EMBL; AK221404; BAD94362.1; -; mRNA.
DR PIR; T03994; T03994.
DR PIR; T03995; T03995.
DR RefSeq; NP_192728.2; NM_117058.4.
DR AlphaFoldDB; Q940H7; -.
DR SMR; Q940H7; -.
DR STRING; 3702.AT4G09900.1; -.
DR ESTHER; arath-AT4g09900; Hydroxynitrile_lyase.
DR MEROPS; S33.A67; -.
DR iPTMnet; Q940H7; -.
DR PaxDb; Q940H7; -.
DR PRIDE; Q940H7; -.
DR ProteomicsDB; 250642; -.
DR EnsemblPlants; AT4G09900.1; AT4G09900.1; AT4G09900.
DR GeneID; 826580; -.
DR Gramene; AT4G09900.1; AT4G09900.1; AT4G09900.
DR KEGG; ath:AT4G09900; -.
DR Araport; AT4G09900; -.
DR TAIR; locus:2140508; AT4G09900.
DR eggNOG; ENOG502QRMV; Eukaryota.
DR HOGENOM; CLU_046066_8_0_1; -.
DR InParanoid; Q940H7; -.
DR OMA; FNMTDAN; -.
DR OrthoDB; 923240at2759; -.
DR PhylomeDB; Q940H7; -.
DR BioCyc; ARA:AT4G09900-MON; -.
DR PRO; PR:Q940H7; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q940H7; baseline and differential.
DR Genevisible; Q940H7; AT.
DR GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR GO; GO:0080030; F:methyl indole-3-acetate esterase activity; IBA:GO_Central.
DR GO; GO:0080032; F:methyl jasmonate esterase activity; IBA:GO_Central.
DR GO; GO:0080031; F:methyl salicylate esterase activity; IBA:GO_Central.
DR GO; GO:0009694; P:jasmonic acid metabolic process; IBA:GO_Central.
DR GO; GO:0009696; P:salicylic acid metabolic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR045889; MES/HNL.
DR PANTHER; PTHR10992; PTHR10992; 1.
DR Pfam; PF12697; Abhydrolase_6; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Chloroplast; Hydrolase; Plastid; Reference proteome; Transit peptide.
FT TRANSIT 1..77
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 78..349
FT /note="Putative methylesterase 12, chloroplastic"
FT /id="PRO_0000418186"
FT REGION 61..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 173
FT /note="Acyl-ester intermediate"
FT /evidence="ECO:0000250|UniProtKB:Q6RYA0"
FT ACT_SITE 300
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:Q6RYA0"
FT ACT_SITE 328
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:Q6RYA0"
SQ SEQUENCE 349 AA; 38930 MW; 15317F780BFA0F91 CRC64;
MGNRVICMKK KDVVIRSGGD GSRSKRVNRS QRKLLADEEN LHRRALSMAI HQAQVSQRFD
GSMSRRIGST SSRRGTLSDS FSNNKQVPEF LESLKVKKFV LVHGEGFGAW CWYKTIASLE
ESGLSPVTVD LAGSGFNMTD ANSVSTLEEY SKPLIELIQN LPAEEKVILV GHSTGGACVS
YALERFPEKI SKAIFICATM VTDGQRPFDV FADELGSAER FMKESQFLIY GNGKDNPATG
FMFEKQHMKG LYFNQSPNKD IALSMISMRP VPLGPMMEKL SLSAERYGKG RRFYVQTLDD
LALSPDVQEK LVRENSPEAV FKIKGSDHCP FFSKPQSLHK ILLEIAQIP
