ID   MES19_ARATH             Reviewed;         260 AA.
AC   F4IMK4; O80473;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2012, sequence version 2.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Putative methylesterase 19 {ECO:0000303|PubMed:18467465};
DE            Short=AtMES19 {ECO:0000303|PubMed:18467465};
DE            EC=3.1.1.- {ECO:0000250|UniProtKB:Q9SG92};
GN   Name=MES19 {ECO:0000303|PubMed:18467465};
GN   OrderedLocusNames=At2g23570 {ECO:0000312|Araport:AT2G23570};
GN   ORFNames=F26B6.22 {ECO:0000312|EMBL:AAC23770.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 82-260.
RC   STRAIN=cv. Columbia;
RA   Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA   Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY.
RX   PubMed=18467465; DOI=10.1104/pp.108.118224;
RA   Yang Y., Xu R., Ma C.J., Vlot A.C., Klessig D.F., Pichersky E.;
RT   "Inactive methyl indole-3-acetic acid ester can be hydrolyzed and activated
RT   by several esterases belonging to the AtMES esterase family of
RT   Arabidopsis.";
RL   Plant Physiol. 147:1034-1045(2008).
CC   -!- FUNCTION: Putative methylesterase.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Methylesterase
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC23770.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAC23770.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC003040; AAC23770.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ056539; AAY78691.1; -; mRNA.
DR   PIR; T01146; T01146.
DR   RefSeq; NP_001318275.1; NM_001335855.1.
DR   AlphaFoldDB; F4IMK4; -.
DR   SMR; F4IMK4; -.
DR   ESTHER; arath-MES19; Hydroxynitrile_lyase.
DR   PaxDb; F4IMK4; -.
DR   PRIDE; F4IMK4; -.
DR   GeneID; 816889; -.
DR   KEGG; ath:AT2G23570; -.
DR   Araport; AT2G23570; -.
DR   TAIR; locus:2046812; AT2G23570.
DR   InParanoid; F4IMK4; -.
DR   OrthoDB; 923240at2759; -.
DR   PRO; PR:F4IMK4; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; F4IMK4; baseline and differential.
DR   GO; GO:0080030; F:methyl indole-3-acetate esterase activity; IBA:GO_Central.
DR   GO; GO:0080032; F:methyl jasmonate esterase activity; IBA:GO_Central.
DR   GO; GO:0080031; F:methyl salicylate esterase activity; IBA:GO_Central.
DR   GO; GO:0009694; P:jasmonic acid metabolic process; IBA:GO_Central.
DR   GO; GO:0009696; P:salicylic acid metabolic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR045889; MES/HNL.
DR   PANTHER; PTHR10992; PTHR10992; 1.
DR   Pfam; PF12697; Abhydrolase_6; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..260
FT                   /note="Putative methylesterase 19"
FT                   /id="PRO_0000418191"
FT   ACT_SITE        81
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000250|UniProtKB:Q6RYA0"
FT   ACT_SITE        210
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:Q6RYA0"
FT   ACT_SITE        238
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:Q6RYA0"
SQ   SEQUENCE   260 AA;  29001 MW;  6FA2E144D5D97D21 CRC64;
     MEKKRFVLVH AVCHGAWSWY KVKTKLEAAG HCVTAVDLAA SGINMTIVEE IQTLMDYSKP
     LLNFMSSLGS DDDKVILVAH SMGGIPAALA ADIFSCKISA VVFLAAFMPD TRNPPAYVFE
     KLIRSIPREE WLDTAFGRYG NPDCPLESAL LGPKFMAKKV YQRSPIEDLE LAKMLVRVNP
     LVTNNLAGAR SFTGEGYGSV TRIYIISGED NILPEDYQRW MIRNFPVKEV MEIKDADHMA
     MFSKPKELCA LLLEIADKYA