ID   MES1_SCHPO              Reviewed;         101 AA.
AC   P41005;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Protein mes1;
GN   Name=mes1; ORFNames=SPAC5D6.08c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 38364 / 968;
RX   PubMed=8082199; DOI=10.1007/bf00351668;
RA   Kishida M., Nagai T., Nakaseko Y., Shimoda C.;
RT   "Meiosis-dependent mRNA splicing of the fission yeast Schizosaccharomyces
RT   pombe mes1+ gene.";
RL   Curr. Genet. 25:497-503(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   FUNCTION.
RX   PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA   Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA   Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA   Smith G.R., Moreno S.;
RT   "A large-scale screen in S. pombe identifies seven novel genes required for
RT   critical meiotic events.";
RL   Curr. Biol. 15:2056-2062(2005).
RN   [4]
RP   FUNCTION, AND INTERACTION WITH SLP1.
RX   PubMed=15791259; DOI=10.1038/nature03406;
RA   Izawa D., Goto M., Yamashita A., Yamano H., Yamamoto M.;
RT   "Fission yeast Mes1p ensures the onset of meiosis II by blocking
RT   degradation of cyclin Cdc13p.";
RL   Nature 434:529-533(2005).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Specifically required for meiosis II (MII). Binds to slp1, an
CC       activator of the anapahase promoting complex/cyclcosome (APC/C), and
CC       counteracts its function in promoting proteolysis of cdc13. By
CC       suppressing the degradation of cdc13 at anaphase I this protein may
CC       help maintain a sufficient level of cdc2 kinase activity to complete
CC       MII. {ECO:0000269|PubMed:15791259, ECO:0000269|PubMed:16303567}.
CC   -!- SUBUNIT: Interacts with slp1. {ECO:0000269|PubMed:15791259}.
CC   -!- INTERACTION:
CC       P41005; P78972: slp1; NbExp=2; IntAct=EBI-1553555, EBI-1252744;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- INDUCTION: Preferentially expressed under nitrogen starvation
CC       conditions.
CC   -!- MISCELLANEOUS: Expression of the full-length mes1 protein requires the
CC       presence of the mei2 protein.
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DR   EMBL; D25544; BAA05027.1; -; Genomic_DNA.
DR   EMBL; CU329670; CAB10856.1; -; Genomic_DNA.
DR   PIR; S44068; S44068.
DR   RefSeq; NP_593361.1; NM_001018793.2.
DR   AlphaFoldDB; P41005; -.
DR   BioGRID; 278351; 8.
DR   ELM; P41005; -.
DR   IntAct; P41005; 2.
DR   STRING; 4896.SPAC5D6.08c.1; -.
DR   PaxDb; P41005; -.
DR   PRIDE; P41005; -.
DR   EnsemblFungi; SPAC5D6.08c.1; SPAC5D6.08c.1:pep; SPAC5D6.08c.
DR   GeneID; 2541861; -.
DR   KEGG; spo:SPAC5D6.08c; -.
DR   PomBase; SPAC5D6.08c; mes1.
DR   VEuPathDB; FungiDB:SPAC5D6.08c; -.
DR   HOGENOM; CLU_2211473_0_0_1; -.
DR   OMA; SHGFHPY; -.
DR   PRO; PR:P41005; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:1990948; F:ubiquitin ligase inhibitor activity; IDA:PomBase.
DR   GO; GO:1990946; P:meiosis I/meiosis II transition; IMP:PomBase.
DR   GO; GO:1905187; P:negative regulation of metaphase/anaphase transition of meiosis I; IMP:PomBase.
DR   GO; GO:1902103; P:negative regulation of metaphase/anaphase transition of meiotic cell cycle; IMP:PomBase.
PE   1: Evidence at protein level;
KW   Cytoplasm; Meiosis; Nucleus; Reference proteome.
FT   CHAIN           1..101
FT                   /note="Protein mes1"
FT                   /id="PRO_0000096438"
FT   REGION          1..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..101
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   101 AA;  11318 MW;  44FAF2267FF3F817 CRC64;
     MVNTDNKENE PPNMEKAHMD SSNALYRVQR PLQRRPLQEL SIELVKPSQT ITVKKSKKST
     NSSSYFAQLH AASGQNPPPS VHSSHKQPSK ARSPNPLLSM R