MES6_ARATH
ID MES6_ARATH Reviewed; 265 AA.
AC F4IMK2; F4IMK1; O80471; Q84W83;
DT 11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Putative methylesterase 6 {ECO:0000303|PubMed:18467465};
DE Short=AtMES6 {ECO:0000303|PubMed:18467465};
DE EC=3.1.1.- {ECO:0000250|UniProtKB:Q9SG92};
DE AltName: Full=Alpha/beta fold hydrolase/esterase 1;
GN Name=MES6 {ECO:0000303|PubMed:18467465}; Synonyms=ABE1;
GN OrderedLocusNames=At2g23550 {ECO:0000312|Araport:AT2G23550};
GN ORFNames=F26B6.20 {ECO:0000312|EMBL:AAC23782.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=18467465; DOI=10.1104/pp.108.118224;
RA Yang Y., Xu R., Ma C.J., Vlot A.C., Klessig D.F., Pichersky E.;
RT "Inactive methyl indole-3-acetic acid ester can be hydrolyzed and activated
RT by several esterases belonging to the AtMES esterase family of
RT Arabidopsis.";
RL Plant Physiol. 147:1034-1045(2008).
CC -!- FUNCTION: Putative methylesterase.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4IMK2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4IMK2-2; Sequence=VSP_044005;
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Methylesterase
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC23782.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAO42147.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC003040; AAC23782.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002685; AEC07464.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07465.1; -; Genomic_DNA.
DR EMBL; BT004125; AAO42147.1; ALT_INIT; mRNA.
DR PIR; T01144; T01144.
DR RefSeq; NP_001318274.1; NM_001335853.1. [F4IMK2-1]
DR RefSeq; NP_179936.3; NM_127919.4.
DR RefSeq; NP_850042.2; NM_179711.2. [F4IMK2-2]
DR AlphaFoldDB; F4IMK2; -.
DR SMR; F4IMK2; -.
DR STRING; 3702.AT2G23550.1; -.
DR ESTHER; arath-MES6; Hydroxynitrile_lyase.
DR MEROPS; S33.A63; -.
DR iPTMnet; F4IMK2; -.
DR PaxDb; F4IMK2; -.
DR PRIDE; F4IMK2; -.
DR ProteomicsDB; 232234; -. [F4IMK2-1]
DR EnsemblPlants; AT2G23550.1; AT2G23550.1; AT2G23550. [F4IMK2-1]
DR EnsemblPlants; AT2G23550.2; AT2G23550.2; AT2G23550. [F4IMK2-2]
DR GeneID; 816887; -.
DR Gramene; AT2G23550.1; AT2G23550.1; AT2G23550. [F4IMK2-1]
DR Gramene; AT2G23550.2; AT2G23550.2; AT2G23550. [F4IMK2-2]
DR KEGG; ath:AT2G23550; -.
DR Araport; AT2G23550; -.
DR TAIR; locus:2046773; AT2G23550.
DR InParanoid; F4IMK2; -.
DR OMA; MIADCPV; -.
DR OrthoDB; 923240at2759; -.
DR PRO; PR:F4IMK2; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IMK2; baseline and differential.
DR Genevisible; F4IMK2; AT.
DR GO; GO:0080030; F:methyl indole-3-acetate esterase activity; IBA:GO_Central.
DR GO; GO:0080032; F:methyl jasmonate esterase activity; IBA:GO_Central.
DR GO; GO:0080031; F:methyl salicylate esterase activity; IBA:GO_Central.
DR GO; GO:0009694; P:jasmonic acid metabolic process; IBA:GO_Central.
DR GO; GO:0009696; P:salicylic acid metabolic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR045889; MES/HNL.
DR PANTHER; PTHR10992; PTHR10992; 1.
DR Pfam; PF12697; Abhydrolase_6; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Hydrolase; Reference proteome.
FT CHAIN 1..265
FT /note="Putative methylesterase 6"
FT /id="PRO_0000418180"
FT ACT_SITE 84
FT /note="Acyl-ester intermediate"
FT /evidence="ECO:0000250|UniProtKB:Q6RYA0"
FT ACT_SITE 213
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:Q6RYA0"
FT ACT_SITE 241
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:Q6RYA0"
FT VAR_SEQ 44..72
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_044005"
FT CONFLICT 153
FT /note="L -> P (in Ref. 3; AAO42147)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 265 AA; 29743 MW; E1BFDFDD231E079D CRC64;
MENKNQKRFV LIHGVCHGAW TWDKVKTQLE VAGHCVTAVD LAASGINMTK VEEIQTLNDY
CKPLLEFLSS LGSDDGKVIV VAHSMGGISA ALAADSFACK IAAIVFLTAF MPDTINPPAY
VYEKLLRSIP QEEWLDTTCV NYGKPDFPLQ YTLLGPKFMA KKMYQNSPVQ DLEVVKTLVR
ENPLVTNNLA GTRSFSEEGY GSVTRIYIVC REDLVEVEDY QRWMISNFPP KEVMEIKCAD
HMPMFSKPQE VCALLLEIAN KYCKN
