ID   MESD_CHICK              Reviewed;         220 AA.
AC   Q5ZKK4;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=LRP chaperone MESD {ECO:0000305};
DE   AltName: Full=LDLR chaperone MESD;
DE   AltName: Full=Mesoderm development candidate 2;
DE   AltName: Full=Mesoderm development protein;
DE   Flags: Precursor;
GN   Name=mesd; Synonyms=mesdc2; ORFNames=RCJMB04_10e14;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=White leghorn; TISSUE=Embryo;
RX   PubMed=16939661; DOI=10.1186/1471-2164-7-220;
RA   Han J.Y., Park T.S., Kim J.N., Kim M.A., Lim D., Lim J.M., Kim H.;
RT   "Gene expression profiling of chicken primordial germ cell ESTs.";
RL   BMC Genomics 7:220-220(2006).
CC   -!- FUNCTION: Chaperone specifically assisting the folding of beta-
CC       propeller/EGF modules within the family of low-density lipoprotein
CC       receptors (LDLRs). Acts as a modulator of the Wnt pathway, since some
CC       LDLRs are coreceptors for the canonical Wnt pathway (By similarity).
CC       {ECO:0000250|UniProtKB:Q9ERE7}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q9ERE7}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q9ERE7}.
CC   -!- SIMILARITY: Belongs to the MESD family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG31739.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AJ720080; CAG31739.1; ALT_FRAME; mRNA.
DR   EMBL; DR420681; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; Q5ZKK4; -.
DR   SMR; Q5ZKK4; -.
DR   BioGRID; 677117; 1.
DR   IntAct; Q5ZKK4; 1.
DR   STRING; 9031.ENSGALP00000010323; -.
DR   PaxDb; Q5ZKK4; -.
DR   VEuPathDB; HostDB:geneid_415475; -.
DR   eggNOG; KOG4357; Eukaryota.
DR   HOGENOM; CLU_111621_0_0_1; -.
DR   InParanoid; Q5ZKK4; -.
DR   PhylomeDB; Q5ZKK4; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR019330; MESD.
DR   PANTHER; PTHR17600; PTHR17600; 1.
DR   Pfam; PF10185; Mesd; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Endoplasmic reticulum; Glycoprotein; Reference proteome; Signal;
KW   Wnt signaling pathway.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..220
FT                   /note="LRP chaperone MESD"
FT                   /id="PRO_0000385019"
FT   REGION          56..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          97..170
FT                   /note="Structured core"
FT                   /evidence="ECO:0000250"
FT   REGION          172..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           217..220
FT                   /note="Prevents secretion from ER"
FT   COMPBIAS        56..75
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..220
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        187
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   220 AA;  24692 MW;  663982BAED40D934 CRC64;
     MAAAARWAAL GLALWLCAAA HAEEPEGKRR AGPAKKKDIR DYNDADMARL LEQWEKDDDI
     EEGDLPEHKR PPAPIDFSKI DPGKPESILK LTKKGKTLMM FVTVSGNPTE KETEEITSLW
     QGSLFNANYD VQRFIVGSNR AIFMLRDGGY AWEIKDFLIS QERCADVTLE GQVYPGKGAD
     GSEKGRNKTK PEKAKKKKDA EKSKSSHEDN RAQTKQREDL