MESD_LEUME
ID MESD_LEUME Reviewed; 722 AA.
AC Q10418;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Mesentericin-Y105 transport/processing ATP-binding protein MesD;
DE EC=3.4.22.-;
DE EC=7.-.-.-;
GN Name=mesD;
OS Leuconostoc mesenteroides.
OG Plasmid pHY30.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Leuconostoc.
OX NCBI_TaxID=1245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Y105;
RX PubMed=7551032; DOI=10.1099/13500872-141-7-1637;
RA Fremaux C., Hechard A., Cenatiempo Y.;
RT "Mesentericin Y105 gene clusters in Leuconostoc mesenteroides Y105.";
RL Microbiology 141:1637-1645(1995).
CC -!- FUNCTION: Involved in the export process of the bacteriocin
CC mesentericin-Y105.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; X81803; CAA57402.1; -; Genomic_DNA.
DR PIR; S52205; S52205.
DR AlphaFoldDB; Q10418; -.
DR SMR; Q10418; -.
DR MEROPS; C39.001; -.
DR TCDB; 3.A.1.112.8; the atp-binding cassette (abc) superfamily.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043214; F:ABC-type bacteriocin transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005897; Pept_C39_ABC_bacteriocin.
DR InterPro; IPR005074; Peptidase_C39.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF03412; Peptidase_C39; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR TIGRFAMs; TIGR01193; bacteriocin_ABC; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS50990; PEPTIDASE_C39; 1.
PE 3: Inferred from homology;
KW ATP-binding; Bacteriocin transport; Cell membrane; Hydrolase; Membrane;
KW Nucleotide-binding; Plasmid; Protease; Protein transport; Thiol protease;
KW Translocase; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..722
FT /note="Mesentericin-Y105 transport/processing ATP-binding
FT protein MesD"
FT /id="PRO_0000092502"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 518..538
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 16..143
FT /note="Peptidase C39"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00362"
FT DOMAIN 173..455
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 489..722
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00362,
FT ECO:0000255|PROSITE-ProRule:PRU00434"
FT ACT_SITE 22
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00362"
FT BINDING 522..529
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00362,
FT ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 722 AA; 79916 MW; 8452E899F8C02E16 CRC64;
MVKTPMFHKK IDYISQVDER DCGVAALAMI LAHYKTRLSL AKLRDLAKTD MEGTTALGIV
KAANALDFET MPIQADLSLF DKKDLPYPFI AHVIKEGKYP HYYVVYGMKG DQLLIADPDN
TVGKTKMTKA HFNEEWTGVS IFIAPNPTYK PTKEKKRSLT SFIPVITRQK LLVINIVIAA
LLVTLVSILG SYYLQGIIDT YIPNNMKNTL GIVSLGLIFA YVIQQLLSYA RDYLLIVMGQ
RLSIDIILSY IKHIFELPMS FFATRRTGEI VSRFTDANAI IEALASTMLS VFLDLGILVI
VGTVLVVQNS TLFLISLIAI PAYALVVWLF MRPFSKMNND QMQAGSMLSS SIIEDINGVE
TIKALNSEAT AYHKIDHEFV TYLEKSFVYA KTEAVQNAIK SLLQLSLNVV ILWVGAQLVM
TNKISVGQLI TYNALLGFFT DPLQNIINLQ TKLQQASVAN NRLNEVYLVD SEFKDSHQMT
EKITPNSSLV ADHITYKYGF GAPAIDDVSL TITAGEKIAL VGISGSGKST LVKLLVNFFQ
PESGTISLGP TPLANLDKHE LRGHINYLPQ EPFIFSGSIM ENLLLGAKPG TTQEDIIRAV
EIAEIKDDIE KMSQGFGTEL AESGNISGGQ KQRIALARAI LVDSPVLILD ESTSNLDVLT
EKKIIDNLMK LTEKTIIFVA HRLTISQRVD RILTMQSGKI IEDGTHDTLL KAGGFYASLF
NH
