ID   MET17_BOVIN             Reviewed;         462 AA.
AC   Q2TBP8;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Methyltransferase-like protein 17, mitochondrial {ECO:0000305};
DE            EC=2.1.1.- {ECO:0000305};
DE   Flags: Precursor;
GN   Name=METTL17 {ECO:0000250|UniProtKB:Q3U2U7};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable S-adenosyl-L-methionine-dependent RNA
CC       methyltransferase required to stabilize the mitochondrial small
CC       ribosomal subunit (mt-SSU). Required for protein translation in
CC       mitochondria. {ECO:0000250|UniProtKB:Q3U2U7}.
CC   -!- SUBUNIT: Interacts with mitochondrial small ribosomal subunit (mt-SSU)
CC       subunits MRPS15 and MRPS27. {ECO:0000250|UniProtKB:Q3U2U7}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:Q3U2U7}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. Rsm22 family.
CC       {ECO:0000305}.
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DR   EMBL; BC109846; AAI09847.1; -; mRNA.
DR   RefSeq; NP_001033631.1; NM_001038542.2.
DR   AlphaFoldDB; Q2TBP8; -.
DR   SMR; Q2TBP8; -.
DR   STRING; 9913.ENSBTAP00000008681; -.
DR   PaxDb; Q2TBP8; -.
DR   PRIDE; Q2TBP8; -.
DR   GeneID; 514880; -.
DR   KEGG; bta:514880; -.
DR   CTD; 64745; -.
DR   eggNOG; KOG2539; Eukaryota.
DR   InParanoid; Q2TBP8; -.
DR   OrthoDB; 1439584at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:1904047; F:S-adenosyl-L-methionine binding; ISS:UniProtKB.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0042274; P:ribosomal small subunit biogenesis; ISS:UniProtKB.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR015324; Ribosomal_Rsm22-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF09243; Rsm22; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   2: Evidence at transcript level;
KW   Methyltransferase; Mitochondrion; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase; Transit peptide.
FT   TRANSIT         1..31
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..462
FT                   /note="Methyltransferase-like protein 17, mitochondrial"
FT                   /id="PRO_0000312162"
SQ   SEQUENCE   462 AA;  51557 MW;  A7815CBA8122C9A2 CRC64;
     MATGRGSRYL LTIGRWRRSF GIAPQFRALA ALVPGVSHVD NKSDFLGKRP HRRHPGILQL
     SCVRLPQALA EAGQLLLLGS AMPNMEKQVQ ALTNYLWSRH LPVEPEELQR RAVLLEKKIL
     ENADSCQTEK HHEEILHALR RTTYHWQELS YSEGLSLVYM AARLDGGFAA VSRAFHEIQA
     RLPEFQPQTL MDFGSGTGSV TWAAHSTWGQ SLREYMCVDS SAAMLELAEK LLKGGSGSGM
     PCVPGVFFRQ FLPVSPKVQF DVVVAAFSLS ELPSKADRTD VVQTLWRKTG HFLVLIENGT
     KAGHSLLMDA RDLVLNGKEK SPLDPRPGFV FAPCPHELPC PQLTASKPLA CSFSQAYYPI
     PFSWNKKPKE EKFSLVILAR GSPEKANRWP RITQPVLKRP RHVHCHLCCP DGHMQHAVIT
     ARRHGRDLYR CARVSSWGDL LPVITPLELP PSAQDAQDAP ES