ID   MET23_DICDI             Reviewed;         254 AA.
AC   Q54KW9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Methyltransferase-like protein 23;
DE            EC=2.1.1.-;
GN   ORFNames=DDB_G0287111;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable methyltransferase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. METTL23
CC       family. {ECO:0000305}.
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DR   EMBL; AAFI02000096; EAL63920.1; -; Genomic_DNA.
DR   RefSeq; XP_637401.1; XM_632309.1.
DR   AlphaFoldDB; Q54KW9; -.
DR   SMR; Q54KW9; -.
DR   STRING; 44689.DDB0267162; -.
DR   PaxDb; Q54KW9; -.
DR   EnsemblProtists; EAL63920; EAL63920; DDB_G0287111.
DR   GeneID; 8625932; -.
DR   KEGG; ddi:DDB_G0287111; -.
DR   dictyBase; DDB_G0287111; -.
DR   eggNOG; KOG2793; Eukaryota.
DR   HOGENOM; CLU_1095939_0_0_1; -.
DR   InParanoid; Q54KW9; -.
DR   OMA; RCNEKTI; -.
DR   PhylomeDB; Q54KW9; -.
DR   PRO; PR:Q54KW9; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR019410; Methyltransf_16.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR14614; PTHR14614; 1.
DR   Pfam; PF10294; Methyltransf_16; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..254
FT                   /note="Methyltransferase-like protein 23"
FT                   /id="PRO_0000328893"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   254 AA;  29727 MW;  63E3E6E941861469 CRC64;
     MKSFIFRQNP RKQQQEQNNL VDYSDSDDDE ECNDDIFVNN EIIINVSEKS SKDYGLFIWD
     GSLVLSWYLF TLTKNNPQFW NGKNVLELNA GVALPSILLS KLGVNKIIIT DRIDGFIEIQ
     NNIIDNLNLN GFNINNNNNI NDNKIFIEPL SWGNFEKFSN QLTSSSIDYL ITSDCFYDNT
     KNYDDIFATW YYFLLKNDKL VILLTYQVRC NEKTIFNYLK KWKLKSEILS IKDISIPNYN
     IDSEIILIKI TKNQ