MET24_HUMAN
ID MET24_HUMAN Reviewed; 366 AA.
AC Q5JXM2; Q6ZSU5;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Probable methyltransferase-like protein 24 {ECO:0000305};
DE EC=2.1.1.- {ECO:0000305};
DE Flags: Precursor;
GN Name=METTL24; Synonyms=C6orf186;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 198-366.
RC TISSUE=Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: Probable methyltransferase. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000305}.
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DR EMBL; AL445068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL050350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK127146; BAC86851.1; -; mRNA.
DR CCDS; CCDS43489.1; -.
DR RefSeq; NP_001116836.1; NM_001123364.1.
DR AlphaFoldDB; Q5JXM2; -.
DR BioGRID; 608890; 1.
DR STRING; 9606.ENSP00000344071; -.
DR GlyGen; Q5JXM2; 1 site, 1 O-linked glycan (1 site).
DR PhosphoSitePlus; Q5JXM2; -.
DR BioMuta; METTL24; -.
DR DMDM; 205830266; -.
DR EPD; Q5JXM2; -.
DR MassIVE; Q5JXM2; -.
DR PaxDb; Q5JXM2; -.
DR PeptideAtlas; Q5JXM2; -.
DR PRIDE; Q5JXM2; -.
DR Antibodypedia; 49566; 64 antibodies from 10 providers.
DR DNASU; 728464; -.
DR Ensembl; ENST00000338882.5; ENSP00000344071.4; ENSG00000053328.9.
DR GeneID; 728464; -.
DR KEGG; hsa:728464; -.
DR MANE-Select; ENST00000338882.5; ENSP00000344071.4; NM_001123364.3; NP_001116836.1.
DR UCSC; uc010kdu.2; human.
DR CTD; 728464; -.
DR DisGeNET; 728464; -.
DR GeneCards; METTL24; -.
DR HGNC; HGNC:21566; METTL24.
DR HPA; ENSG00000053328; Tissue enhanced (smooth).
DR neXtProt; NX_Q5JXM2; -.
DR OpenTargets; ENSG00000053328; -.
DR PharmGKB; PA134906793; -.
DR VEuPathDB; HostDB:ENSG00000053328; -.
DR eggNOG; ENOG502QRD5; Eukaryota.
DR GeneTree; ENSGT00390000002881; -.
DR HOGENOM; CLU_061403_0_0_1; -.
DR InParanoid; Q5JXM2; -.
DR OMA; TQIACDH; -.
DR OrthoDB; 1540267at2759; -.
DR PhylomeDB; Q5JXM2; -.
DR TreeFam; TF330614; -.
DR PathwayCommons; Q5JXM2; -.
DR BioGRID-ORCS; 728464; 9 hits in 1067 CRISPR screens.
DR ChiTaRS; METTL24; human.
DR GenomeRNAi; 728464; -.
DR Pharos; Q5JXM2; Tdark.
DR PRO; PR:Q5JXM2; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5JXM2; protein.
DR Bgee; ENSG00000053328; Expressed in smooth muscle tissue and 104 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR026913; METTL24.
DR PANTHER; PTHR32026; PTHR32026; 1.
DR Pfam; PF13383; Methyltransf_22; 1.
PE 2: Evidence at transcript level;
KW Methyltransferase; Reference proteome; Secreted; Signal; Transferase.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..366
FT /note="Probable methyltransferase-like protein 24"
FT /id="PRO_0000343743"
FT REGION 36..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..63
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 281
FT /note="L -> F (in dbSNP:rs2334321)"
FT /id="VAR_044502"
FT CONFLICT 308
FT /note="G -> V (in Ref. 2; BAC86851)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 366 AA; 41330 MW; 8B9A3DCE659A846D CRC64;
MARERPPGRG CGVLRRCLLG AVLLFGLRLC AELRRAGPGS PTRSAPPGPA WRPPGPHLPP
APGQPRGASR RQVTYVRSGR RAPPGGGGSG TPEPGCCAPR GRPRRKGPRW HIDLQPWAGS
AQSLDEEAWR FLRYISTTQI ACNHMNTDSL ATDSSPTHKP WSVCLDDRFN LAHQIRNKQC
RLYSLGLGSD DTHFEVSMAN NGCEVHRFDP SVKSAHILES QHLWYHRLSI DWRDPHPAVA
AQKPHSNTRK LGSILNEFGH HKIDVLKADL ESAEWKVLEN LILEDVLEQI GQLIFEIHLH
WPGFEVSGSD SSVVRFWYSL LKELEQKDFR LFHSYKDLSK PQLFLKKDIF NASSCYTLSW
VNTRWK
