MET24_MOUSE
ID MET24_MOUSE Reviewed; 363 AA.
AC Q8CCB5;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Probable methyltransferase-like protein 24 {ECO:0000305};
DE EC=2.1.1.- {ECO:0000305};
DE Flags: Precursor;
GN Name=Mettl24;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable methyltransferase. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000305}.
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DR EMBL; AK033488; BAC28315.1; -; mRNA.
DR EMBL; CH466540; EDL04960.1; -; Genomic_DNA.
DR EMBL; BC147316; AAI47317.1; -; mRNA.
DR EMBL; BC147317; AAI47318.1; -; mRNA.
DR CCDS; CCDS23799.1; -.
DR RefSeq; NP_808461.1; NM_177793.3.
DR AlphaFoldDB; Q8CCB5; -.
DR STRING; 10090.ENSMUSP00000049997; -.
DR iPTMnet; Q8CCB5; -.
DR PhosphoSitePlus; Q8CCB5; -.
DR PaxDb; Q8CCB5; -.
DR PRIDE; Q8CCB5; -.
DR ProteomicsDB; 296002; -.
DR Antibodypedia; 49566; 64 antibodies from 10 providers.
DR DNASU; 327747; -.
DR Ensembl; ENSMUST00000058747; ENSMUSP00000049997; ENSMUSG00000045555.
DR GeneID; 327747; -.
DR KEGG; mmu:327747; -.
DR UCSC; uc007exd.1; mouse.
DR CTD; 728464; -.
DR MGI; MGI:3045338; Mettl24.
DR VEuPathDB; HostDB:ENSMUSG00000045555; -.
DR eggNOG; ENOG502QRD5; Eukaryota.
DR GeneTree; ENSGT00390000002881; -.
DR HOGENOM; CLU_061403_0_0_1; -.
DR InParanoid; Q8CCB5; -.
DR OMA; TQIACDH; -.
DR OrthoDB; 1540267at2759; -.
DR PhylomeDB; Q8CCB5; -.
DR TreeFam; TF330614; -.
DR BioGRID-ORCS; 327747; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Mettl24; mouse.
DR PRO; PR:Q8CCB5; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8CCB5; protein.
DR Bgee; ENSMUSG00000045555; Expressed in indifferent gonad and 79 other tissues.
DR Genevisible; Q8CCB5; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR026913; METTL24.
DR PANTHER; PTHR32026; PTHR32026; 1.
DR Pfam; PF13383; Methyltransf_22; 1.
PE 2: Evidence at transcript level;
KW Methyltransferase; Reference proteome; Secreted; Signal; Transferase.
FT SIGNAL 1..38
FT /evidence="ECO:0000255"
FT CHAIN 39..363
FT /note="Probable methyltransferase-like protein 24"
FT /id="PRO_0000343744"
FT REGION 38..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 363 AA; 40631 MW; 0FDFED6C04E9DB38 CRC64;
MATVKPPGRG CGALPRWLLG AALLLGLRLC MELRHAGSGP PGRGDSPGPP RTHLLSAPGS
PRGARRRQVT YVRSGRRVLP RGGGSTTSPE PSCCAQGGLL RRKGSRWHIE LQPWAGPSRS
LDEEASRFLS YISTTQIACD HMGTDSLATD SSPAPKPWLV CLDDRFGLAH QIRSKRCRLY
SLGLGSDDTH FEVSMANGGC EVHRFDPSVK SAHVLERQGL WHHRLSIDWR DPHPAVAAQK
PHGNTRKLGS ILNEFGHHKI DVLKADLESA EWKVLENLIL EDVLEQIGQL VFEIHLHWPG
FEVSGSESGV VRFWYSLLKE LERKHFRLFH TYKDLTKPQL FLKKDLFNAS SCYTLSWVNT
KWR
